DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32305 and gcy-1

DIOPT Version :9

Sequence 1:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster
Sequence 2:	NP_496039.1	Gene:	gcy-1 / 191639	WormBaseID:	WBGene00001528	Length:	1137	Species:	Caenorhabditis elegans

Alignment Length:	282	Identity:	82/282 - (29%)
Similarity:	147/282 - (52%)	Gaps:	44/282 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 QNIVYQ---LVMKKENGLLESI--LPRKMIRTLQEEICSRIEDQDKNFT--------------PS 282
            :||..|   ||.|::..|::.:  :..:...||:||    ||::.|..|              |.
Worm   817 ENICSQMKGLVSKQKTNLMDHVFNMLEEYTSTLEEE----IEERTKELTLEKKKADILLSRMLPK 877

  Fly   283 ------KAGLRKLFLEP--YPNVSILVADMVNYTHLTTTLEAPQLVEILHDLFVNFDLAANRNRA 339
                  |||..   :||  :.:|::..:|:|.:|.|.:.....|.|.:|:||:.|||....::..
Worm   878 QVAERLKAGQT---VEPEGFDSVTVFFSDVVKFTILASKCSPFQTVNLLNDLYSNFDTIIEQHGV 939

  Fly   340 MRIKFLGDSYNCVAGIP--NYFPAHASCCVDQALEMIHITQGVS---SRRELDINLRIGVHSGEV 399
            .:::.:||.|.||:|:|  |.: ||....||.:|:.:...:..:   ..|| ::.|||||:||..
Worm   940 YKVESIGDGYLCVSGLPTRNGY-AHIKQIVDMSLKFMEYCKSFNIPHLPRE-NVELRIGVNSGPC 1002

  Fly   400 FAGIIGHTKWQFDIWSKDVDITNRLESSGLPGLVHVSQRTLSMLDEHYIFREGTEAAKNDPILQQ 464
            .||::|.:..::.::...|:..:|:||:|.|.|:|::....|:|..||..:..| :::.:.|::.
Worm  1003 VAGVVGLSMPRYCLFGDTVNTASRMESNGKPSLIHLTNDAHSLLTTHYPNQYET-SSRGEVIIKG 1066

  Fly   465 AGI-RTFLVSNRLPDAVEPGEL 485
            .|: .||.|..|..: :||.||
Worm  1067 KGVMETFWVHGRFGE-MEPTEL 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	65/226 (29%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	50/159 (31%)
		CYCc	814..1056	CDD:214485
		Nucleotidyl_cyc_III	845..1081	CDD:299850
gcy-1	NP_496039.1	PBP1_NPR_GC_like	35..449	CDD:107347
		ANF_receptor	53..432	CDD:279440
		PKc_like	555..821	CDD:304357	2/3 (67%)
		HNOBA	<840..883	CDD:285003	9/46 (20%)
		CYCc	862..1051	CDD:214485	55/193 (28%)
		Guanylate_cyc	889..1077	CDD:278633	58/190 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900