DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32305 and gcy-20

DIOPT Version :9

Sequence 1:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster
Sequence 2:	NP_507101.1	Gene:	gcy-20 / 184797	WormBaseID:	WBGene00001545	Length:	1108	Species:	Caenorhabditis elegans

Alignment Length:	302	Identity:	79/302 - (26%)
Similarity:	137/302 - (45%)	Gaps:	48/302 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 NLIFSFFTIIRDYG--LRRAILSRYQLVYQNIVYQLVMKKENGLLESILPRKMIRTLQEEICSRI 272
            ||:...|.::..|.  |...:..|.:.:.:.      .||.:.||..:|||.:...|  ::...:
Worm   811 NLMDHVFNMLETYASTLEEEVSDRTKELTEE------KKKSDVLLYRMLPRMVADKL--KLGQTV 867

  Fly   273 EDQDKNFTPSKAGLRKLFLEPYPNVSILVADMVNYTHLTTTLEAPQLVEILHDLFVNFDLAANRN 337
            |.                 |.:..|:|..:|:|.:|.|.......|:|.:|:||:..||....:|
Worm   868 EP-----------------ETFEQVTIFFSDVVQFTTLAGKCTPLQVVTLLNDLYTIFDGIIEQN 915

  Fly   338 RAMRIKFLGDSYNCVAGIPN-------YFPAHASCCVDQALEMIHITQGVSSRRELDINLRIGVH 395
            ...:::.:||.|.||:|:|:       ...|..|.....:||...: |.:.:.|   ||||||::
Worm   916 DVYKVETIGDGYLCVSGLPHRNGNDHIRHIARMSLGFLSSLEFFRV-QHLPAER---INLRIGIN 976

  Fly   396 SGEVFAGIIGHTKWQFDIWSKDVDITNRLESSGLPGLVHVSQRTLSMLDEHY-IFREGTEAAKND 459
            .|.|.||::|.|..::.::...|:..:|:||:|.||.:||:.....||.:.. .||  || ::.:
Worm   977 CGSVVAGVVGLTMPRYCLFGDAVNTASRMESNGKPGQIHVTAEANRMLTQVVGGFR--TE-SRGE 1038

  Fly   460 PILQQAGI-RTFLVSNR-----LPDAVEPGELDDELSSASIN 495
            .|::..|: .||.:...     .|....|..:....|..||:
Worm  1039 VIIKGKGVMETFWLLGEESGYTAPSKAAPKVIQHRQSIRSIS 1080

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	58/205 (28%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	51/159 (32%)
		CYCc	814..1056	CDD:214485
		Nucleotidyl_cyc_III	845..1081	CDD:299850
gcy-20	NP_507101.1	PBP1_NPR_GC_like	22..439	CDD:107347
		ANF_receptor	44..418	CDD:279440
		PKc_like	536..801	CDD:304357
		STYKc	562..801	CDD:214568
		HNOBA	<818..861	CDD:285003	10/48 (21%)
		CYCc	840..1032	CDD:214485	60/220 (27%)
		Guanylate_cyc	867..1054	CDD:278633	60/210 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900