DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32305 and Npr1

DIOPT Version :9

Sequence 1:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster
Sequence 2:	NP_032753.5	Gene:	Npr1 / 18160	MGIID:	97371	Length:	1057	Species:	Mus musculus

Alignment Length:	298	Identity:	86/298 - (28%)
Similarity:	123/298 - (41%)	Gaps:	76/298 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   789 ERHVNYLRKFNYFMRVCYEEAHQQTDEKLRSIKIIMANILPTHVAQVYKVRRPHDQLYYENFSKV 853
            |::.|.|.:.       .||..|...|:.|..:.::..|||..||:..|   ..:.:..|.|..|
Mouse   817 EQYANNLEEL-------VEERTQAYLEEKRKAEALLYQILPHSVAEQLK---RGETVQAEAFDSV 871

  Fly   854 AVMFASIENFNADTAG------LRILHEIICCFDDLLVDYQTRYKIEKIKVMGWTYMVACGLETD 912
            .:.|:.|..|.|.:|.      :.:|:::..|||.::.::.. ||:|.|   |..|||..||
Mouse   872 TIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDV-YKVETI---GDAYMVVSGL--- 929

  Fly   913 HYTDFSIDIPVKQPEADSEIRRGSSVLTVHFGSTEDDEMSGDNVSQPYAQVQDVAVLVMTEFALD 977
                              .:|.|.    :|                    .::||     ..||.
Mouse   930 ------------------PVRNGQ----LH--------------------AREVA-----RMALA 947

  Fly   978 LLRIMHDIRYNYVFSEYDTFLTGSLKIGISHGSVMAGVVGLSKPHYDIWGHTVNMASRMSSTGLL 1042
            ||..:...|..:...|     ...|:|||..|.|.||||||..|.|.::|.|||.||||.|.|..
Mouse   948 LLDAVRSFRIRHRPQE-----QLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEA 1007

  Fly  1043 DNIQVTRHTAKVLRQFN-IRCNYRGHTEVKGVGKVPTY 1079
            ..|.::..|..||.:|: .....||..|:||.|||.||
Mouse  1008 LRIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTY 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485
		Nucleotidyl_cyc_III	292..445	CDD:299850
		CYCc	814..1056	CDD:214485	68/247 (28%)
		Nucleotidyl_cyc_III	845..1081	CDD:299850	72/242 (30%)
Npr1	NP_032753.5	PBP1_NPR_A	32..439	CDD:107380
		ANF_receptor	50..410	CDD:279440
		PK_GC-A_B	530..803	CDD:270944
		TyrKc	543..797	CDD:197581
		HNOBA	<812..857	CDD:285003	13/46 (28%)
		CYCc	836..1025	CDD:214485	70/250 (28%)
		Guanylate_cyc	863..1049	CDD:278633	72/242 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900