DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32305 and gcy-33

DIOPT Version :9

Sequence 1:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster
Sequence 2:	NP_001256392.1	Gene:	gcy-33 / 179644	WormBaseID:	WBGene00001553	Length:	947	Species:	Caenorhabditis elegans

Alignment Length:	863	Identity:	166/863 - (19%)
Similarity:	293/863 - (33%)	Gaps:	311/863 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   367 VDQALEMIHITQGVSSRRELDINLRIGVHSGEVFAGIIGHTKWQFDIWSKDVDITN---RLESSG 428
            |.|..:.||...|....       :|||.:|..|.        ||.|.:...|:.|   |..|..
Worm    47 VPQMFKAIHEITGTPYE-------QIGVLAGRFFV--------QFLIRNGYGDLMNVMGRRFSDF 96

  Fly   429 LPGLVHVSQRTLSMLDEHYIFREG-----------TEAAKNDPILQQAGIRTFLVSNRLPDAVEP 482
            :.||.::          |..||..           ...:::..||.....||..:|..:...||.
Worm    97 IKGLDNI----------HEYFRFSYPKLRAPSFYCKSESEDGLILHYRSRRTGYLSYVIGQLVEL 151

  Fly   483 GELDDELSSASINSCRLSYGGYYEEIQIKAQRE-------IMK-EVDQMAVGHCFIEWRRSSSMK 539
            ..:..:|...               ||:..::|       ::| ..|.:.:|       :...:|
Worm   152 ARVFYQLDIG---------------IQVLKKKEKGRFTFVVLKISFDNVGLG-------QDLKLK 194

  Fly   540 KQDFN-EEYLFSNQIHLVLGVFRSWKREWEFHNLPDLMIKYTMLL-VLCAGLAIMSINLIEEATY 602
            ::..| .|||..:.        :|:.:.:.||      |.:...| :|.||..::::       .
Worm   195 ERVKNLNEYLPVDT--------KSFLQMFPFH------IAFNKKLEILMAGQGLLNL-------M 238

  Fly   603 PDILVLLGILLI----LLILCILAGYKKLRLQWKKLTP---MSQPSC-FLSRWLLRISERIEDSL 659
            |:|   .|:|:.    |...||            |.|.   |...:| |....|..:.::.|:::
Worm   239 PNI---QGLLMTDVFDLQRPCI------------KFTAEGIMVHQNCVFQIESLHPVVKQTEENI 288

  Fly   660 FVRI-PLTMVVLLLLYVMSSQAVFSCDVAKLELSIIEAHLYNEKS--YAECFGPWTV-----TY- 715
            .|:| .:|.                 |...||...:..:.|..:|  |....||.||     |:
Worm   289 TVQINDITE-----------------DKVSLEKKTVMDNEYGLESLPYVTLRGPITVLKSSETFL 336

  Fly   716 ----CVVIVISLLFVVPGCPLVIKILAGLLILGLHLGTVHLYYG----------FAFERSETTDL 766
                |||..:..:|.                :||:|..    :|          ...::|:|...
Worm   337 LLATCVVDTLDTMFK----------------MGLYLND----FGESDCNREIIMATIQKSDTLKT 381

  Fly   767 GLKSDYAHTWYLVALFIVLVLRERHVNYLRKFNYFMRVCYEEAHQQTDEKLRSIKIIMANILPTH 831
            .|:::...:..|.                            |..::..|..::.:.::..::|..
Worm   382 MLENEKRRSEVLT----------------------------EMTREISEAKKTARTLLTQMMPYE 418

  Fly   832 VAQVYKVRRPHDQLYYENFSKVAVMFASIENFNADTAGLRILHEIICCFD------DLLVDYQTR 890
            |||.  :.|.....:.|.|..|::.|..:.:|:..:..:... |::...:      |.:||....
Worm   419 VAQT--MMRSGSVDHCEAFECVSIGFIRVCDFSKISLFIEAF-EVVNLLNTIYSHLDSIVDTHGV 480

  Fly   891 YKIEKIKVMGWTYMVACGLE-TDHYTDFSIDIPVKQPEADSEIRRGSSVLTVHFGSTEDDEMSGD 954
            ||:|.|   |.:||::.|.. .|.|                                 |.||..|
Worm   481 YKVETI---GESYMISAGCPYRDDY---------------------------------DAEMVSD 509

  Fly   955 NVSQPYAQVQDVAVLVMTEFALDLLRIMHDIRYNYVFSEYDTFLTGSLKIGISHGSVMAGVVGLS 1019
            ...:..:.::                       ::.:..:|......:|.||..|.|:.||||:.
Worm   510 CCLEMVSHIK-----------------------SFEYQSHDAVKKVLIKCGIFTGPVVGGVVGVR 551

  Fly  1020 KPHYDIWGHTVNMASRMSSTGLLD-NIQVTRHTA-KVLRQFN--IRCNYRGHTEVKGVGKVPTYL 1080
            .|.|.::|.|||.||||.|:.... .||:.:.|. :|.:|.:  .|...:|:..|||.|.:..|.
Worm   552 TPRYCLFGDTVNTASRMESSNQTPMTIQIGQRTKDRVEKQASGAFRIKPKGNVFVKGKGDMRVYE 616

  Fly  1081 VVVDPDLTFQDHDQVSMSMKDSKSWVIDTLSLSFTPSFVPPKSSTSDEEEAEGELEEN------- 1138
            :           ::.....:..||   |.|.          |...::::|||..|:|:
Worm   617 I-----------EKKKGRARYKKS---DPLR----------KKMVAEKKEAEELLDEDNEGHRSS 657

  Fly  1139 ----VSEGDELEVSIHER 1152
                :|.|:.::.|...|
Worm   658 ALSRMSLGESIDSSSSRR 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	20/84 (24%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	19/80 (24%)
		CYCc	814..1056	CDD:214485	54/250 (22%)
		Nucleotidyl_cyc_III	845..1081	CDD:299850	56/246 (23%)
gcy-33	NP_001256392.1	HNOB	2..164	CDD:377902	31/156 (20%)
		HNOBA	204..423	CDD:369471	55/321 (17%)
		CYCc	402..598	CDD:214485	55/257 (21%)
		COG5134	<595..744	CDD:227463	21/105 (20%)
		TDA11	<710..>898	CDD:293689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910