DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32305 and gcy-18

DIOPT Version :9

Sequence 1:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster
Sequence 2:	NP_502449.2	Gene:	gcy-18 / 178237	WormBaseID:	WBGene00001543	Length:	1113	Species:	Caenorhabditis elegans

Alignment Length:	361	Identity:	87/361 - (24%)
Similarity:	164/361 - (45%)	Gaps:	69/361 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 QGSSVYVLGMVV-SIIYIGYAF--------YMQYLND---QVSFYLLASYAIYLFTLNLIFSFFT 217
            |...:|..|||: .|::....|        .:.||.|   .||..:.....::. .||      .
Worm   764 QAGDIYSFGMVMYEILFRSLPFRDNTNISELVDYLADGSKTVSPEIQNQMGLHP-DLN------A 821

  Fly   218 IIRDY---------GLRRAILSRYQLVYQNIVYQLVMKKENGLLESILP---------RKMI--R 262
            ::||.         .:||..|:.          ::|:|.:..|::.::.         .|::  |
Worm   822 LLRDCWSENPEIRPSIRRVRLNT----------EMVLKTKGSLVDQMMKMMEQYANNLEKLVAER 876

  Fly   263 T-LQEEICSRIEDQDKNFTPS------KAGLRKLFLEPYPNVSILVADMVNYTHLTTTLEAPQLV 320
            | :.||...|.:.......|:      |.| |.:..:.|.:.:||.:|:|.:|.:.:.....::|
Worm   877 TGMLEEANIRADQLLTQLLPAYVANELKMG-RSVAPKLYSSATILFSDIVGFTTICSGSTPLEVV 940

  Fly   321 EILHDLFVNFDLAANRNRAMRIKFLGDSYNCVAGIP--NYFPAHASCCVDQALEMIHITQG--VS 381
            .:|:.|:..||....||::.:::.:||:|..|:|||  |.: .|:....:.||:|.....|  :.
Worm   941 NMLNGLYTGFDECITRNKSYKVETIGDAYMVVSGIPEENEY-NHSRNIANTALDMRQYLTGYQIP 1004

  Fly   382 SRRELDINLRIGVHSGEVFAGIIGHTKWQFDIWSKDVDITNRLESSGLPGLVHVSQRTLSMLDEH 446
            .|....:..|.|.|:|.|.||::|.|..::.::...|::::|:||:|.||::.:|:.....:..|
Worm  1005 HRPTHRVRCRWGFHTGSVAAGVVGLTCPRYCLFGDTVNVSSRMESTGTPGMIQMSEEAHMHIRAH 1069

  Fly   447 YIFREGTEAAKNDPILQQAG---IRTFLVSNRLPDA 479
            :.....||..:    :|..|   .|||.:.:|:.||
Worm  1070 HPVFTTTERGE----VQVKGKGTCRTFWLEDRVGDA 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	56/219 (26%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	44/156 (28%)
		CYCc	814..1056	CDD:214485
		Nucleotidyl_cyc_III	845..1081	CDD:299850
gcy-18	NP_502449.2	Periplasmic_Binding_Protein_Type_1	87..448	CDD:299141
		ANF_receptor	87..395	CDD:279440
		PKc_like	549..846	CDD:304357	19/98 (19%)
		HNOBA	<857..903	CDD:285003	7/45 (16%)
		CYCc	882..1073	CDD:214485	51/192 (27%)
		Guanylate_cyc	909..1095	CDD:278633	52/190 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900