Protein Alignment CG32305 and gcy-8

DIOPT Version :9

• Sequence 1: NP_728725.2
• Gene: CG32305 / 317967
• FlyBaseID: FBgn0052305
• Length: 1164
• Species: Drosophila melanogaster
• Sequence 2: NP_501324.2
• Gene: gcy-8 / 177584
• WormBaseID: WBGene00001535
• Length: 1152
• Species: Caenorhabditis elegans
• Alignment Length: 1169
• Identity: 213/1169 - (18%)
• Similarity: 380/1169 - (32%)
• Gaps: 450/1169 - (38%)

  Fly   148 DHVVLVSVYMTLPIAFYQGSSVYVLGMVVSIIYIGYAFYMQYLNDQVSFYLLASYAIYLFTLNLI 212
            |.|..::.:..:||                   |||......|.|:.::..||  .|.|.|.|.|
 Worm   146 DAVARMAAFWNIPI-------------------IGYMAASNNLADKNAYPTLA--RISLRTTNSI 189

  Fly   213 F-SFFTIIRDYGLRRA-------------ILSRYQLVYQ---NIVYQLVMKK--------ENGLL 252
            . :...::|.||..:.             :||..::.:|   |:|.:::..:        .:|||
 Worm   190 AEATCAMLRHYGWNKVAIITNTGILAYDRVLSFEEVFHQRGINVVKKIMFDEFADSKAMIASGLL 254

  Fly   253 ESILPRKMI--------RTLQEEICSRIEDQDKN--------------------FTPSKAGLRKL 289
            ..|.....|        |....|..:....|..|                    :|.:...:.:.
 Worm   255 NDIKNSARIVVCLFSNTRESSREFLTAANTQGMNVNEYGYVFPWLQDGGKDASPWTGADGSMLQK 319

  Fly   290 FLEPYPNVSILVADMVNYTHLTTTLEAPQLVEILHDLFVNFDLAANRNRAMRIKFLG--DSYNCV 352
            ..:.|.| :|::.|:.::.:   |:..|         |:.           |||.:|  ::...:
 Worm   320 VKDQYAN-AIIIDDVNSFDN---TIVGP---------FIE-----------RIKDVGLTEADVDI 360

  Fly   353 AGIPNYFPAHASCCVDQALEMIHITQGVSSRRELDINLRIGVHSGEVFAGIIGHTKWQFDIWSKD 417
            |.|..|.      .:..||::    ..:::|:.|:       .:|:....:.|...||
 Worm   361 ANIYGYL------YLFDALKL----YAIAARKVLN-------ETGKAENLLNGRMMWQ------- 401

  Fly   418 VDITNRLESSGLPGLVHVSQRTLSMLDEHYIFREGTEAAKNDPILQQAGIRTFLVS----NRLPD 478
              ...:|:..|:.|...::...:||.|.          |:..|:     .|.|.||    :.||.
 Worm   402 --NMRKLKFVGMVGASGIASGQVSMDDR----------AERAPL-----YRGFFVSPNSDSVLPM 449

  Fly   479 A-VEPGELD--DELSSASINSCRLSYGGYYEEIQIKAQREIMKEVDQ------------------ 522
            . :||..||  |.:::.|         |.||.:.....|:....||:
 Worm   450 VHMEPTMLDNCDGIANKS---------GCYEIVVTDIMRDFWPSVDRKMPKDEPDCGYRNERCDY 505

  Fly   523 --MAVGHC-------------------------------------FIEWRRSSSM--------KK 540
              :.:|..                                     ||:..:..||        |.
 Worm   506 TLIIIGAALILLFIVAAVSAFFAQKILEKRALDKLPFRIYRDDLQFIDEEQLKSMLSLGSTRTKM 570

  Fly   541 QDFNEEYLFSNQIHLVLGVFRSWKREWEFHNLPDLMIKYTMLLVLCAGLAIMS-INLIEEATYPD 604
            .:.|    :.::.|.::|.           |...:..||.....:....|..: |.|::.|.:.:
 Worm   571 SNMN----YGSRNHAIVGT-----------NTHAIYHKYVQRRPIVFNRADKTLIQLMKAAVHDN 620

  Fly   605 ILVLLGI-------LLILLILC---------------------------ILAGYKKLRLQ----W 631
            |...||:       :|::...|                           ||||.:.|...    .
 Worm   621 INPFLGMVWNEREEMLLVWKFCSRGTLQDIIYNESIQLDTKFHGAFIRDILAGLEYLHASQIGYH 685

  Fly   632 KKLTPMSQPSCFLSR-WLLRIS--------ERIEDSLFV----------RIPLTMVVLLLL---- 673
            ..|||.   ||.:.| |:::::        ||.|.|..:          :...|....:|.
 Worm   686 GSLTPW---SCLIDRNWMIKLTDYGIADPLERWEKSQSISRDGLTSDDDKSQATQATSILYESPE 747

  Fly   674 ----------------YVMSSQA------VFSCDVAKLELSIIEAHLYNEKSYAECFGPW----- 711
                            ::..:|.      |::..:...|: |..|..:.|.:.......|
 Worm   748 MLKNREKNRVRRVDQDWMRQTQTRRQLGDVYAFGLVMYEI-IFRALPFPEGTNQSELVEWLRDGS 811

  Fly   712 -----TVTYCVVIVISLLFVVPGC--------PLVIKILAGLLILGLHLGTVHLYYGFAFERSET 763
                 |:....|:.:.|..::..|        |.:.:|                      :.:..
 Worm   812 KVVKPTIPQNKVLNMDLSALIQDCWNTTPEMRPSLRRI----------------------KLNVE 854

  Fly   764 TDLGLKSDYAHTWYLVALFIVLVLRERHVNYLRKFNYFMRVCYEEAHQQTDEKLRSIKIIMANIL 828
            |.|.:|......        :..:.|::.|.|.|.........|||:|:.|.       :::.:|
 Worm   855 TYLNIKGSLVDQ--------MTRMMEQYANNLEKLVAERTGMLEEANQRADR-------LLSQLL 904

  Fly   829 PTHVAQVYKVRRPHDQLYYENFSKVAVMFASIENFN---ADTAGLRILHEIICCFD--DLLVDYQ 888
            |.:||...|:.||   :..:.|:...|:|:.|..|.   .:.:.|.::..:...||  |..:..:
 Worm   905 PAYVANELKLGRP---VPPKTFTSSTVLFSDIVGFTEMCQNASPLEVVAVLNGIFDGFDQFIARK 966

  Fly   889 TRYKIEKIKVMGWTYMVACGLETDHYTDFSIDIPVKQPEADSEIRRGSSVLTVHFGSTEDDEMSG 953
            ..||:|.|   |..|||..|:                ||.:.
 Worm   967 DAYKVETI---GDAYMVVSGV----------------PEENG----------------------- 989

  Fly   954 DNVSQPYAQVQDVAVLVMTEFALDLLRIMHDIRYNYVFSEYDTFLTGSLKIGISHGSVMAGVVGL 1018
                  :..:.::|     ..|||:.:.:.:.   .|..:.||.:  ..::|...|.|.|.||||
 Worm   990 ------HRHINEIA-----SIALDVHKFLSEF---IVPHKRDTKV--QCRLGFHTGPVAAAVVGL 1038

  Fly  1019 SKPHYDIWGHTVNMASRMSSTGLLDNIQVTRHTAK--VLRQF-NIRCNYRGHTEVKGVGKVPTY 1079
            :.|.|.::|.||||||||.|.......|:: .|||  :|::: :..|..||...:||.|...||
 Worm  1039 NAPRYCLFGDTVNMASRMESNSEPGKTQIS-ETAKNLLLKEYPDYICEQRGEIPIKGKGLCMTY 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	37/227 (16%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	27/154 (18%)
		CYCc	814..1056	CDD:214485	59/248 (24%)
		Nucleotidyl_cyc_III	845..1081	CDD:299850	60/243 (25%)
gcy-8	NP_501324.2	ANF_receptor	87..442	CDD:279440	68/381 (18%)
		Periplasmic_Binding_Protein_Type_1	94..434	CDD:299141	64/373 (17%)
		PKc_like	558..850	CDD:304357	49/332 (15%)
		HNOBA	<866..912	CDD:285003	13/60 (22%)
		CYCc	891..1084	CDD:214485	63/261 (24%)
		Guanylate_cyc	918..1105	CDD:278633	60/243 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900