DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32305 and Gucy2e

DIOPT Version :9

Sequence 1:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster
Sequence 2:	XP_036012232.1	Gene:	Gucy2e / 14919	MGIID:	105123	Length:	1139	Species:	Mus musculus

Alignment Length:	297	Identity:	77/297 - (25%)
Similarity:	141/297 - (47%)	Gaps:	49/297 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 NIVYQLVMKKENGLLESILPRKMIRTLQEEICSRIED----------QDKNFT---------PSK 283
            ::.:.|......|...:|:. .|:|.| |:..|.:||          |:|..|         ||.
Mouse   833 DLTFDLFKSINKGRKTNIID-SMLRML-EQYSSNLEDLIRERTEELEQEKQKTDRLLTQMLPPSV 895

  Fly   284 AGLRKL--FLEP--YPNVSILVADMVNYTHLTTTLEAPQLVEILHDLFVNFDLAANRNRAMRIKF 344
            |...|:  .:||  :..|::..:|:|.:|.::...|..::|::|:||:..||.....:...:::.
Mouse   896 AEALKMGTSVEPEYFEEVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGAHDVYKVET 960

  Fly   345 LGDSYNCVAGIP-NYFPAHASCCVDQALEMIHITQGVSSRR--ELDINLRIGVHSGEVFAGIIGH 406
            :||:|...:|:| .....||:...:.:|:::........|.  |:.:.:|||:|||...||::|.
Mouse   961 IGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGSFRMRHMPEVPVRIRIGLHSGPCVAGVVGL 1025

  Fly   407 TKWQFDIWSKDVDITNRLESSGLPGLVHVSQ---RTLSMLDEHYIF--REGTEAAKNDPILQQAG 466
            |..::.::...|:..:|:||:|||..:||:.   |.|..||:.:..  |..||       |:..|
Mouse  1026 TMPRYCLFGDTVNTASRMESTGLPYRIHVNMSTVRILRALDQGFQMECRGRTE-------LKGKG 1083

  Fly   467 IR-TFLVSNRL--------PDAVEPGELDDELSSASI 494
            |. |:.:..||        |..::||..:..:|...|
Mouse  1084 IEDTYWLVGRLGFNKPIPKPPDLQPGASNHGISLQEI 1120

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	61/226 (27%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	45/160 (28%)
		CYCc	814..1056	CDD:214485
		Nucleotidyl_cyc_III	845..1081	CDD:299850
Gucy2e	XP_036012232.1	PBP1_sensory_GC_DEF-like	58..465	CDD:380594
		PK_GC-2D	570..845	CDD:270945	1/11 (9%)
		HNOBA	<854..899	CDD:400168	13/45 (29%)
		CYCc	879..1070	CDD:214485	52/190 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810