DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32305 and Gucy2c

DIOPT Version :10

Sequence 1:NP_728725.2 Gene:CG32305 / 317967 FlyBaseID:FBgn0052305 Length:1164 Species:Drosophila melanogaster
Sequence 2:NP_001120790.1 Gene:Gucy2c / 14917 MGIID:106903 Length:1072 Species:Mus musculus


Alignment Length:386 Identity:85/386 - (22%)
Similarity:161/386 - (41%) Gaps:100/386 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   208 TLNLIFSFFTIIRDYGLRRAILSRYQLVYQNI---------VYQLVMKKENGLLESILPRKMIRT 263
            ||..||..|...::......::.|.||..:|:         :|:....:.:.|...:|||.::::
Mouse   743 TLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADHLNFMLLPRLVVKS 807

  Fly   264 LQEEICSRIEDQDKNFTPSKAGLRKLFLEP--YPNVSILVADMVNYTHLTTTLEAPQLVEILHDL 326
            |:|                     |..:||  |..|:|..:|:|.:|.:.......::|::|:|:
Mouse   808 LKE---------------------KGIVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDI 851

  Fly   327 FVNFDLAANRNRAMRIKFLGDSYNCVAGIP----NYFPAHASCCVDQALEMIHI--TQGVSSRRE 385
            :.:||...:.:...:::.:||:|...:|:|    |   .||......||:::..  |..:.....
Mouse   852 YKSFDQIVDHHDVYKVETIGDAYVVASGLPMRNGN---RHAVDISKMALDILSFIGTFELEHLPG 913

  Fly   386 LDINLRIGVHSGEVFAGIIGHTKWQFDIWSKDVDITNRLESSGLPGLVHVSQRTLSML------- 443
            |.:.:|||||||...||::|....::.::...|:..:|:||:|||..:|:|..|:::|       
Mouse   914 LPVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTITILKRTDCQF 978

  Fly   444 -----DEHYIFREGTEAAKNDPILQQAGIRTFLVSNRLPDAVEPGELDDELSSASINSCRLSYGG 503
                 .|.|:...|||.             |:.::         |..|.|.:..|..:       
Mouse   979 LYEVRGETYLKGRGTET-------------TYWLT---------GMKDQEYNLPSPPT------- 1014

  Fly   504 YYEEIQIKAQREIMKEVDQMAVGHCFIEWRRSSSMK----------KQDFNEEYLFSNQIH 554
                  ::.|:.:..|...|.|.  .::.|::|..|          |:.|.|....:|..|
Mouse  1015 ------VENQQRLQTEFSDMIVS--ALQKRQASGKKSRRPTRVASYKKGFLEYMQLNNSDH 1067

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32305NP_728725.2 AcyC 62..451 CDD:441717 65/271 (24%)
Nucleotidyl_cyc_III 292..445 CDD:448371 46/172 (27%)
Nucleotidyl_cyc_III 845..1081 CDD:448371
Gucy2cNP_001120790.1 Periplasmic_Binding_Protein_type1 35..415 CDD:471960
Protein Kinases, catalytic domain 480..749 CDD:473864 3/5 (60%)
CYCc 787..978 CDD:214485 53/214 (25%)
Blue background indicates that the domain is not in the aligned region.

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