DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32305 and LRRK2

DIOPT Version :9

Sequence 1:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster
Sequence 2:	NP_940980.4	Gene:	LRRK2 / 120892	HGNCID:	18618	Length:	2527	Species:	Homo sapiens

Alignment Length:	1344	Identity:	252/1344 - (18%)
Similarity:	437/1344 - (32%)	Gaps:	457/1344 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 TVKDLEWRHLKNKCQNLRLELACSRLRELALMS------------NVVQIIWHVELLMVAHVILL 72
            |:|.|..| |.|..:..::|.....|.:|.:.:            |:     ||.||:|....:.
Human    15 TLKKLIVR-LNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNI-----HVPLLIVLDSYMR 73

  Fly    73 LALVKDI------ILVTMVPYFAVMLFSP---------------FIMLLSMQNN------VGMIT 110
            :|.|:.:      .|:.:.|.....|..|               .:.:|::.|.      :|:.|
Human    74 VASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILKMLTVHNASVNLSVIGLKT 138

  Fly   111 NTLISWLMALFLTSMDLVSDLLGTIYSGAAYPTVPCYDHVVLVSVYMTLPIAFYQGSSVYVLGMV 175
            ..|:.....:.|..:|..||:...|:.  |..:.|..|.|..:.. ..|.:.|.:.|...:...|
Human   139 LDLLLTSGKITLLILDEESDIFMLIFD--AMHSFPANDEVQKLGC-KALHVLFERVSEEQLTEFV 200

  Fly   176 VSIIYIGYAFYMQYLNDQVSFYL-----LASYAIYLFTLNLIFSFFTIIRDYG------------ 223
            .:..|:.....:....|:....|     |.|.||....:.::.|  ..:|.|.
Human   201 ENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVEVLMS--GNVRCYNIVVEAMKAFPMS 263

  Fly   224 ----------LRRAILSR-YQLVYQNIVYQLVMK-----KENGLLESILPRKMIRTLQEEIC--S 270
                      |.|..|.. :.::..|.|::.|:|     .||..|: |.....:..|.|.|.  .
Human   264 ERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQQYPENAALQ-ISALSCLALLTETIFLNQ 327

  Fly   271 RIEDQDKNFTPSKAGLR-KLF-LEPYPNVSILVADMVNYTHLTTTLEAPQLVE----ILHDLFVN 329
            .:|::::|......|.. ||| ||            ..|..||...:...:.|    .|::|.:
Human   328 DLEEKNENQENDDEGEEDKLFWLE------------ACYKALTWHRKNKHVQEAACWALNNLLM- 379

  Fly   330 FDLAANRNRAMRIKFLGDSYNCVAGIPNYFPAHASCCVD---------------QALEMIHITQG 379
                  ...::..| :||.       ..:||||....:.               .||..: :.|.
Human   380 ------YQNSLHEK-IGDE-------DGHFPAHREVMLSMLMHSSSKEVFQASANALSTL-LEQN 429

  Fly   380 VSSRREL---DINLRI------GVHSGEVFAG---IIGH----TKWQFDIWS----KDVDITNRL 424
            |:.|:.|   .|:|.:      .:||.||...   ::.|    :....||.:    |.:.:..|.
Human   430 VNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIMAAVVPKILTVMKRH 494

  Fly   425 ESSGLPGLVHVSQRTLSMLDEHYIF-------REGTE-----------AAKND------------ 459
            |:| ||..:...:..|     |:|.       ||.||           ..|||
Human   495 ETS-LPVQLEALRAIL-----HFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRF 553

  Fly   460 ---PILQQAGIRTFLVSNRLPDAVEPGELDDELSSA-----------SINSCRLSYGGYYEEIQI 510
               |.:|:.|::........|||:|...|:..:.|.           .|....||..||.
Human   554 IGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQEIQCLGLSLIGYL----- 613

  Fly   511 KAQREIMKEVDQMAVGHCFIEWRRSSSMKKQDFNEEYLFSNQIHLVLGVFR---SWKREWEFHNL 572
                 |.|:...:..||...:...||..:.:|..|  :.:.....:|.:.:   |:.:....|:.
Human   614 -----ITKKNVFIGTGHLLAKILVSSLYRFKDVAE--IQTKGFQTILAILKLSASFSKLLVHHSF 671

  Fly   573 PDLMIKYTMLLVLCAGLAIMSINLIEEATYPDILVLLGILLILLILCILAGYKKLRLQWKKLTPM 637
             ||:|.:.           ||.|::|:....           .|.||.
Human   672 -DLVIFHQ-----------MSSNIMEQKDQQ-----------FLNLCC----------------- 696

  Fly   638 SQPSCFLSRWLLRISERIEDSLFVRI-----PLTMVVLLLLYVMSSQA----VFSCDVAKLELS- 692
               .||..   :.:.:.:::.:..|.     .:.:..||||...::||    ...|.|.:.|.|
Human   697 ---KCFAK---VAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQAKEGSSLICQVCEKESSP 755

  Fly   693 -IIEAHLYNEKSYAECFGPWTVTYCVVIVISLLFVVPGCPLVIKILAGLLILGLHLGTVHLYYGF 756
             ::|. |.|..|..:     .|...:.|.|.     .|...:|.:|...|.|.:...::.| .||
Human   756 KLVEL-LLNSGSREQ-----DVRKALTISIG-----KGDSQIISLLLRRLALDVANNSICL-GGF 808

  Fly   757 AFERSETTDLGLKSDYAHTWYLVALFIVLVLRERHVNYLRKFNYFMRVCYEEAHQQTDEKLRSIK 821
            ...:.|.:.||            .||      ....:.|||              ||
Human   809 CIGKVEPSWLG------------PLF------PDKTSNLRK--------------QT-------- 833

  Fly   822 IIMANILPTHVAQVYKVRRPHDQLYYENFSKVAVMFASIENFNADTAGLRILHEIICCFDDLLVD 886
                ||..|....|.:.:                |.:::|...|..:......:::..||:
Human   834 ----NIASTLARMVIRYQ----------------MKSAVEEGTASGSDGNFSEDVLSKFDE---- 874

  Fly   887 YQTRYKIEKIKVMGWTYMVACGLETDHYTDFSID-IPVKQPEADSEIRRGSSVLTVHFGSTEDDE 950
                          ||::          .|.|:| :..:..:.|||...||.::.....|....|
Human   875 --------------WTFI----------PDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSISVGE 915

  Fly   951 MSGDNVSQ---PYAQVQDVAVLVMTEFALDLLRIMHDIRYNYVFSEYDTFLTGSLKIGISHGSVM 1012
            ...|.|.|   |..|....::..:.:.. |||:     |...:.|..|:..:..|:..:.|...:
Human   916 FYRDAVLQRCSPNLQRHSNSLGPIFDHE-DLLK-----RKRKILSSDDSLRSSKLQSHMRHSDSI 974

  Fly  1013 AGVVGLSKPHY----DIWGHTVNMASRMS-----STGL--LDNIQVTRH-----------TAKVL 1055
            :.:.  |:..|    |:..:.:.....:|     |..|  |:.:::.::           |.|.|
Human   975 SSLA--SEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLCETLKSL 1037

  Fly  1056 RQFNIRCNYRGHTEVKGVGKVPTYL-------------------VVVDPDLTFQDHDQVSMSMKD 1101
            ...::..|        .....|:||                   ||:||.:......|.::|..
Human  1038 THLDLHSN--------KFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN- 1093

  Fly  1102 SKSWVIDTLSLSFTPSFVPPKSSTSDEEEAEGELEENVSEGDEL 1145
                     .|||.|      .:.:|..|   :||:.:.||:::
Human  1094 ---------QLSFVP------ENLTDVVE---KLEQLILEGNKI 1119

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	49/240 (20%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	36/191 (19%)
		CYCc	814..1056	CDD:214485	43/267 (16%)
		Nucleotidyl_cyc_III	845..1081	CDD:299850	44/280 (16%)
LRRK2	NP_940980.4	Required for RAB29-mediated activation. /evidence=ECO:0000269\|PubMed:29212815	1..969		221/1163 (19%)
		LRR 1	983..1004		3/20 (15%)
		leucine-rich repeat	985..1012	CDD:275380	4/26 (15%)
		LRR	1012..>1286	CDD:227223	24/135 (18%)
		LRR 2	1012..1033		1/20 (5%)
		leucine-rich repeat	1013..1036	CDD:275380	2/22 (9%)
		LRR 3	1036..1057		5/28 (18%)
		leucine-rich repeat	1037..1084	CDD:275380	9/54 (17%)
		LRR 4	1059..1080		4/20 (20%)
		LRR 5	1084..1105		6/36 (17%)
		leucine-rich repeat	1085..1108	CDD:275380	8/41 (20%)
		LRR 6	1108..1129		4/12 (33%)
		leucine-rich repeat	1109..1130	CDD:275380	4/11 (36%)
		LRR 7	1130..1150
		leucine-rich repeat	1131..1174	CDD:275380
		LRR 8	1174..1196
		leucine-rich repeat	1175..1197	CDD:275380
		LRR 9	1197..1218
		leucine-rich repeat	1198..1221	CDD:275380
		LRR 10	1221..1241
		leucine-rich repeat	1222..1246	CDD:275380
		LRR 11	1246..1267
		leucine-rich repeat	1247..1269	CDD:275380
		LRR 12	1269..1291
		RocCOR	1334..1507	CDD:206741
		COR	1527..1740	CDD:318343
		STKc_LRRK2	1884..2135	CDD:270970
		WD 1	2139..2183
		WD 2	2188..2228
		WD 3	2233..2276
		WD 4	2281..2327
		WD 5	2333..2377
		WD 6	2402..2438
		WD 7	2443..2497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900