DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32305 and Gucy2f

DIOPT Version :9

Sequence 1:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster
Sequence 2:	NP_446283.1	Gene:	Gucy2f / 116556	RGDID:	620439	Length:	1108	Species:	Rattus norvegicus

Alignment Length:	1087	Identity:	209/1087 - (19%)
Similarity:	340/1087 - (31%)	Gaps:	427/1087 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   299 ILVADMVNYTHLTTTLEAPQLVEILHDLFVNFDLAANRNRAMRIKFLGDSYNCVAGIPNYFPAHA 363
            ||..|......||:.:...|:..       .|...||.........||:|::  .||.::
  Rat    99 ILNEDCQTSKALTSFISHQQMAS-------GFVGPANPGYCEAASLLGNSWD--KGIFSW----- 149

  Fly   364 SCCVDQALEMIHITQGVSSRRELDINLRIGVHSGEVF----AGIIGHTKWQFDIWSKDVD-ITNR 423
             .||:..|:..|.....|  |.|...:|:.|...:.|    ||:|...:   |||....: :::.
  Rat   150 -ACVNHELDNKHSYPTFS--RTLPSPIRVLVTVMKYFQWAHAGVISSDE---DIWVHTANQVSSA 208

  Fly   424 LESSGLP-GLVHVS-------------------------------------------QRTLSMLD 444
            |.|.||| |:|..|                                           ...|.|.|
  Rat   209 LRSHGLPVGVVLTSGQDSRSIQKALQQIRQADRIRIIIMCMHSALIGGETQTHFLELAHDLKMTD 273

  Fly   445 EHYIF-------------REGTEAAKNDPILQQA--GIRTFLVSNR-------LPDAVEPGELDD 487
            ..|:|             ....:..:|:..|::|  .:.|..|.:.       ..:|...||:.:
  Rat   274 GTYVFVPYDVLLYSLPYKHSPYQVLRNNQKLREAYDAVLTITVESHEKTFYEAFTEAAAGGEIPE 338

  Fly   488 ELSSASINSCRLSYGGYYEEIQIKAQ--REIMKEVDQMAVGHCFIEWRRSSSMKKQDFNE----- 545
            :|.|..::..   :|..|..|...||  ...:||..|.:....   .|.|.:|:...||:
  Rat   339 KLDSHQVSPL---FGTIYNSIYFIAQAMSNALKENGQASAASL---TRHSRNMQFYGFNQLIRTD 397

  Fly   546 -------EYLFSNQIHLVLGVFRSWKREWE---------------FHNLP--------------- 573
                   ||:          :..:..:|||               |...|
  Rat   398 SNGNGISEYV----------ILDTNGKEWELRGTYTVDMETELLRFRGTPIHFPGGRPTSADAKC 452

  Fly   574 ----------------DLMIKYTMLLVLCA--GLAIM---SINLIEEATYPD--ILVLLGILLI- 614
                            .:|:.:.:||.|.:  |.|..   .||.|:....|:  :|.|..:..|
  Rat   453 WFAQGKICQGGIDPALAMMVCFALLLALLSINGFAYFIRRRINKIQLIKGPNRILLTLEDVTFIN 517

  Fly   615 --------------LLILCILAGYKKLRLQWK--KLTPMSQPSCFLS------RWLLR------- 650
                          ..|:..:...:..||.:.  .|||.:..:..::      .||.:
  Rat   518 PHFGSKRGSRASVSFQIISEVQSGRSPRLSFSSGSLTPATYENSNIAIYQGDWVWLKKFPPGDFG 582

  Fly   651 -----------ISERIED----------SLFVRIPLTMVVLLLLYVMSSQAVFSCDVAKLE---- 690
                       :.|.::|          ..|....:..:|.......|.:.:.:.|..||:
  Rat   583 DIKSIKSSASDVFEMMKDLRHENVNPLLGFFYDSGMFAIVSEFCSRRSLEDILTQDDVKLDWMFK 647

  Fly   691 ----LSIIEAHLY-NEKSYAECFGPWTVTYCVV---IVI------------------------SL 723
                |.:|:...| :.:.:..  |......|||   .|:                        .|
  Rat   648 SSLLLDLIKGMKYLHHREFIH--GRLKSRNCVVDGRFVLKVTDYGFNNILEMLRLSEEEPSEEEL 710

  Fly   724 LFVVPGCPLVIKIL--AGLLILGLHLGTVHLYYGFAFERSETTDLGLKSDYAHTWYLVALFIVLV 786
            |:..|      ::|  .|.:.||...|.|   |.||....|....|            |.|.::.
  Rat   711 LWTAP------ELLRAPGGIRLGSFAGDV---YSFAIIMQEVMVRG------------APFCMMD 754

  Fly   787 LRERHVNYLRKFN------------------YFMRVCYEEAHQQ--------------------- 812
            |..:.|....|..                  ..|:.|:.||.:|
  Rat   755 LSAKEVIDRLKMPPPVYRPVVSPEFAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTN 819

  Fly   813 -TDEKLRSIKIIMANI-------------------------LPTHVAQVYK---VRRPHDQLYYE 848
             .|..||.::...:|:                         ||..||:..|   ...|      |
  Rat   820 IIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEP------E 878

  Fly   849 NFSKVAVMFASIENFNADTA------GLRILHEIICCFDDLLVDYQTRYKIEKIKVMGWTYMVAC 907
            .|..|.:.|:.|..|...:|      .:.:|:::...||.::..:.. ||:|.|   |..||||.
  Rat   879 GFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDV-YKVETI---GDAYMVAS 939

  Fly   908 GLETDHYTDFSIDIPVKQPEADSEIRRGSSVLTVHFGSTEDDEMSGDNVSQPYAQVQDVAVLVMT 972
            ||                |:.                          |.|:..|::.::::.:::
  Rat   940 GL----------------PKR--------------------------NGSRHAAEIANMSLDILS 962

  Fly   973 EFALDLLRIMHDIRYNYVFSEYDTFLTGSLKIGISHGSVMAGVVGLSKPHYDIWGHTVNMASRMS 1037
            ......:|.|.::...             ::||:..|.|:||||||:.|.|.::|.|||.||||.
  Rat   963 SVGTFKMRHMPEVPVR-------------IRIGLHTGPVVAGVVGLTMPRYCLFGDTVNTASRME 1014

  Fly  1038 STGLLDNIQVTRHTAKVLRQFN--IRCNYRGHTEVKGVGKVPTYLVV 1082
            ||||...|.|:..|..:||..:  .....||.||:||.|...|:.:|
  Rat  1015 STGLPYRIHVSLSTVTILRTLSEGYEVELRGRTELKGKGTEETFWLV 1061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	42/198 (21%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	40/194 (21%)
		CYCc	814..1056	CDD:214485	64/275 (23%)
		Nucleotidyl_cyc_III	845..1081	CDD:299850	64/243 (26%)
Gucy2f	NP_446283.1	PBP1_sensory_GC_DEF_like	54..435	CDD:107366	72/371 (19%)
		ANF_receptor	75..412	CDD:279440	68/348 (20%)
		PKc_like	545..815	CDD:304357	47/292 (16%)
		TyrKc	565..809	CDD:197581	42/266 (16%)
		HNOBA	<824..869	CDD:285003	7/44 (16%)
		CYCc	848..1040	CDD:214485	62/256 (24%)
		Guanylate_cyc	875..1062	CDD:278633	66/252 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810