DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32305 and Adcy8

DIOPT Version :9

Sequence 1:NP_728725.2 Gene:CG32305 / 317967 FlyBaseID:FBgn0052305 Length:1164 Species:Drosophila melanogaster
Sequence 2:NP_033753.2 Gene:Adcy8 / 11514 MGIID:1341110 Length:1249 Species:Mus musculus


Alignment Length:1159 Identity:304/1159 - (26%)
Similarity:524/1159 - (45%) Gaps:239/1159 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 LKNKCQNLRLELACSRL-----RELALMSNVVQIIWHVELLMVAHVILLLALVKDI--ILVTMVP 86
            |:|..::..||....|.     |:..::.||:.::..:.|| |.|:.|..|.:..:  ||:....
Mouse   155 LRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLL-VLHLSLASAPMDPLKGILLGFFT 218

  Fly    87 YFAVMLFSPFIMLLSMQNNVGMITNTLISWLMALFLTSMDLVSDL-LGTIYSGAAYPTVPCYDHV 150
            ...|::.:..::.....::..:..:.:::|:.   :|:..|.:.| .|.:..|..|         
Mouse   219 GIEVVICALVVVRKDNTSHTYLQYSGVVTWVA---MTTQILAAGLGYGLLGDGIGY--------- 271

  Fly   151 VLVSVYMT-----LPIAFYQGSSVYVLGMVVSIIYIGYAFYMQYLNDQVSFY----LLASYAIYL 206
            ||.:::.|     ||:.:     ..:.|:..|::.:    .:|.|..:::.:    :||...:::
Mouse   272 VLFTLFATYSMLPLPLTW-----AILAGLGTSLLQV----TLQVLIPRLAVFSINQVLAQVVLFM 327

  Fly   207 FTLNLIFSFFTIIRDYGLRRAILSRYQLVYQNIVYQLVMKKENGLLESILPRKMIRTLQEEICSR 271
             .:|....|.:.:.|...|:|.|...:.|...:..:...:::..|:.|:|||.::..:..:: :.
Mouse   328 -CMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDM-TN 390

  Fly   272 IEDQDKNFTPSKAGLRKLFLEPYPNVSILVADMVNYTHLTTTLEAPQLVEILHDLFVNFDLAANR 336
            :||:.....     ..::::..|.|||||.||:..:|:|:|||.|.:||.:|::||..||..|:.
Mouse   391 VEDEHLQHQ-----FHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHE 450

  Fly   337 NRAMRIKFLGDSYNCVAGIPNYFPAHASCCVDQALEMIHITQGVSSRRELDINLRIGVHSGEVFA 401
            :..:|||.|||.|.||:|:|.....||.|||:..|.||...:.|.||.:.|:::|||:|||.|..
Mouse   451 HHCLRIKILGDCYYCVSGLPEPRRDHAHCCVEMGLSMIKTIRFVRSRTKHDVDMRIGIHSGSVLC 515

  Fly   402 GIIGHTKWQFDIWSKDVDITNRLESSGLPGLVHVSQRTLSMLDEHYIFREGTEAAKNDPILQQAG 466
            |::|..|||||:||.||||.|:|||.|:||.:|:|:.||..|:..|...||....:|: .|::..
Mouse   516 GVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNE-FLRKHN 579

  Fly   467 IRTFLVSNR------LPDAV-----------------EPGELDDELSSASI------------NS 496
            |.|:|:...      ||:.:                 ..|....||...:|            ||
Mouse   580 IETYLIKQPEESLLCLPEDIVKESVSCSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNS 644

  Fly   497 CRLSYGGYYEEIQIKA-QREIMKEVDQMAVGHCFIEWRRSSSMKKQDFNEEYLFSNQIHLVLGVF 560
            ..|......:.:.::: ..||.|.::..      |:.|....::::......|          :|
Mouse   645 INLLPNHLAQALHVQSGPEEINKRIEHT------IDLRSGDKLRREHIKPFSL----------MF 693

  Fly   561 RSWKREWEFHNLPDLMIKYTMLLVLCAGLAIMSINLIEEATYP-----------DILVLLGILLI 614
            :....|.::..:.|.:.|..:   :||.:.::.|..| ::..|           .||::|...|:
Mouse   694 KDSSLEHKYSQMRDEVFKSNL---VCAFIVLLFITAI-QSLLPSSRLMPMTIQFSILIMLHSALV 754

  Fly   615 LLILCILAGYKKLRLQWKKLTPMSQPSCFLSRWLLRISERIEDSLFVRIPLTMVVLLLLYVMSSQ 679
            |:...  ..||.|.|..:|       :|.   |       |.::...|..:....:|:.::.:..
Mouse   755 LITTA--EDYKCLPLILRK-------TCC---W-------INETYLARNVIIFASILINFLGAVL 800

  Fly   680 AVFSCDVAKLELSIIEAHL-YNEK-------SYAECF---GPWTVTYCVVIVISLLFVVPGCPLV 733
            .:..||..|   ||...:| :|..       ||.|.|   |...:..|.|.:        ....|
Mouse   801 NILWCDFDK---SIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFL--------RLNSV 854

  Fly   734 IKILAGLLILGLH-LGTVHLYYGFAFERSETTDLGLKSDYAHT----WYLVALFIVLVL-RERHV 792
            :|:...|:::.:: |.|..:|.|...........|  .|:..|    ..|:|:|::.|. ..:.:
Mouse   855 LKLAVLLIMIAIYALLTETIYAGLFLSYDNLNHSG--EDFLGTKEASLLLMAMFLLAVFYHGQQL 917

  Fly   793 NYLRKFNYFMRVCYEEAHQQTDEKLRSIKIIMANILPTHVAQVYKVR-RPHDQLYYENFSKVAVM 856
            .|..:.::..||..:|...:..|.....:.::.||||:|||:.:..: |.:::||.:::..|.||
Mouse   918 EYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVM 982

  Fly   857 FASIENF----------NADTAGLRILHEIICCFDDLLVDYQTRYK-IEKIKVMGWTYMVACGLE 910
            ||||..|          |.....||:|:|||..||:||  .:.|:: |||||.:|.|||...||.
Mouse   983 FASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELL--GEDRFQDIEKIKTIGSTYMAVSGLS 1045

  Fly   911 TDHYTDFSIDIPVKQPEADSEIRRGSSVLTVHFGSTEDDEMSGDNVSQPYAQVQDV--AVLVMTE 973
                       |.||                                    |.:|.  .:..:.:
Mouse  1046 -----------PEKQ------------------------------------QCEDKWGHLCALAD 1063

  Fly   974 FALDLLRIMHDIRYNYVFSEYDTFLTGSLKIGISHGSVMAGVVGLSKPHYDIWGHTVNMASRMSS 1038
            |:|.|...:.:|. .:.|:.::      |:||||||||:|||:|..||.|||||.|||:||||.|
Mouse  1064 FSLALTESIQEIN-KHSFNNFE------LRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDS 1121

  Fly  1039 TGLLDNIQVTRHTAKVLRQFNIRCNYRGHTEVKGV----GKVPTYLVV--VDPD 1086
            ||:...|||...|..:|:......:|||...|||:    ||:.||.::  |.|:
Mouse  1122 TGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPN 1175

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32305NP_728725.2 CYCc 251..449 CDD:214485 85/197 (43%)
Nucleotidyl_cyc_III 292..445 CDD:299850 77/152 (51%)
CYCc 814..1056 CDD:214485 86/255 (34%)
Nucleotidyl_cyc_III 845..1081 CDD:299850 88/252 (35%)
Adcy8NP_033753.2 Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..180 6/24 (25%)
Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..107
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 14..33
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 38..40
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 49..51
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 50..118
AC_N <159..398 CDD:292831 47/262 (18%)
CYCc 364..562 CDD:214485 84/203 (41%)
Guanylate_cyc 403..587 CDD:278633 85/184 (46%)
DUF1053 615..709 CDD:283888 16/109 (15%)
CYCc 942..1146 CDD:214485 86/259 (33%)
Guanylate_cyc 971..1170 CDD:278633 88/254 (35%)
Involved in CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 1107..1249 31/69 (45%)
Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250|UniProtKB:P40146 1198..1213
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1221..1249
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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