Protein Alignment CG32305 and Adcy6

DIOPT Version :9

• Sequence 1: NP_728725.2
• Gene: CG32305 / 317967
• FlyBaseID: FBgn0052305
• Length: 1164
• Species: Drosophila melanogaster
• Sequence 2: XP_006520366.3
• Gene: Adcy6 / 11512
• MGIID: 87917
• Length: 1254
• Species: Mus musculus
• Alignment Length: 1180
• Identity: 293/1180 - (24%)
• Similarity: 502/1180 - (42%)
• Gaps: 333/1180 - (28%)

  Fly    64 LMVAHVILLLALVKDIILVTMVP---YFAVMLFSP--FIMLLSMQNNVGMITNTLISWLMALFLT 123
            |::|.::||:|::.........|   |.|::..:.  |::|:.:.|......:::  |:::.
Mouse   240 LLMAVLVLLMAVLLTFHAAPAQPQPAYVALLTCASVLFVVLMVVCNRHSFRQDSM--WVVSY--- 299

  Fly   124 SMDLVSDLLGTIYSG---AAYPTVP-----CYDHVVLVSVYMTLPIAFYQGSSVYVLGMVVSIIY 180
               :|..:|..:..|   ||.|..|     |....|.:: |..|||..   .:..:.|:.:|.::
Mouse   300 ---VVLGILAAVQVGGALAANPHSPSAGLWCPVFFVYIT-YTLLPIRM---RAAVLSGLGLSTLH 357

  Fly   181 IGYAFYMQYLNDQVSFYLLASYAIYLFTLNLIFSFFTIIRDYGLRRA-------ILSRYQLVYQN 238
            :..|:.:...:..:...|.|:..::|.| |.|........:...|:|       |.:|..|.::|
Mouse   358 LILAWQLNSSDPFLWKQLGANVVLFLCT-NAIGVCTHYPAEVSQRQAFQETRGYIQARLHLQHEN 421

  Fly   239 IVYQLVMKKENGLLESILPRKMIRTLQEEICSRIEDQDKNFTPSKAGLRKLFLEPYPNVSILVAD 303
                   :::..||.|:||:.:...::|:|.::.||.         ...|::::.:.|||||.||
Mouse   422 -------RQQERLLLSVLPQHVAMEMKEDINTKKEDM---------MFHKIYIQKHDNVSILFAD 470

  Fly   304 MVNYTHLTTTLEAPQLVEILHDLFVNFDLAANRNRAMRIKFLGDSYNCVAGIPNYFPAHASCCVD 368
            :..:|.|.:...|.:||..|::||..||..|..|..:|||.|||.|.||:|:|.....||.|||:
Mouse   471 IEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVE 535

  Fly   369 QALEMIHITQGVSSRRE---LDINLRIGVHSGEVFAGIIGHTKWQFDIWSKDVDITNRLESSGLP 430
            ..::||   :.:|..||   :::|:|:|:|||.|..|::|..|||||:||.||.:.|.:|:.|..
Mouse   536 MGVDMI---EAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRA 597

  Fly   431 GLVHVSQRTLSMLDEHYIFREGTEAAKNDPILQQAGIRTFLV----------------------- 472
            |.:|:::.||..|:..|....|....:|..:.:|. |.|||:
Mouse   598 GRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQC-IETFLILGASQKRKEEKAMLAKLQRTRAN 661

  Fly   473 ----------------------------------SNR-LPDAVEPGELDDELSSASINSCRLSYG 502
                                              .|| ..||:.|.:..||....:|::
Mouse   662 SMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDNRGAQDALNPEDEVDEFLGRAIDA------ 720

  Fly   503 GYYEEIQIKAQREIMKEVDQMAVGHCFIEWRR-SSSMKKQDFNEEYLFSNQIHLVLGVFRSWKRE 566
                           :.:||:...|.    || ..:.:::|..::|  |.::....|.:
Mouse   721 ---------------RSIDQLRKDHV----RRFLLTFQREDLEKKY--SRKVDPRFGAY------ 758

  Fly   567 WEFHNLPDLMIKYTMLLVLCAGLAIMSINLIEEATYPDILVLLGI-------LLILLILCILAGY 624
                             |.||.|....|..|:...:|...::|||       ||:.:::|.:.
Mouse   759 -----------------VACALLVFCFICFIQLLVFPYSTLILGIYAAIFLLLLVTVLICAVC-- 804

  Fly   625 KKLRLQWKKLTPMSQPSC--FLSRWLLRISERIEDSLFVRIPLTMVVLLLLYVMSSQAVFSCD-- 685
                            ||  |..:.|.|:|..|..|......:.:..:||:::.:...:|:|:
Mouse   805 ----------------SCGSFFPKALQRLSRNIVRSRVHSTAVGIFSVLLVFISAIANMFTCNHT 853

  Fly   686 ------VAKLELS---IIEAHLYNEKSYA------ECFGPWTVTYCVV-------IVISLL---- 724
                  ...|.|:   :...|| .:.:|:      .|.|  |...|..       :::|||
Mouse   854 PIRTCAARMLNLTPADVTACHL-QQLNYSLGLDAPLCEG--TAPTCSFPEYFVGNVLLSLLASSV 915

  Fly   725 -------------FVVPGCPLVIKIL---AGL-----LILGLHLGTVHLYYGFAFERSETTD--- 765
                         |::....||:.:|   |.:     |:||:|        |.| ..:||.|
Mouse   916 FLHISSIGKLAMTFILGFTYLVLLLLGPPAAIFDNYDLLLGVH--------GLA-SSNETFDGLD 971

  Fly   766 ------LGLKSDYAHTWYLVALFIVLVLRERHVNYLRKFNYFMRVCYEEAHQQTDEKLRSIKIIM 824
                  :.||  |.....|:...:.|.|..:.|....:.::..::......::.:|.....:.::
Mouse   972 CPAVGRVALK--YMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLL 1034

  Fly   825 ANILPTHVAQVYKVR-RPHDQLYYENFSKVAVMFASIENFN-------ADTAG---LRILHEIIC 878
            .||||..||..:..| |.:|:|||::...||||||||.||:       |:..|   ||:|:|||.
Mouse  1035 HNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIA 1099

  Fly   879 CFDDLLVDYQTRYKIEKIKVMGWTYMVACGLETDHYTDFSIDIPVKQPEADSEIRRGSSVLTVHF 943
            .||:::.:.:.| ::||||.:|.|||.|.||....|
Mouse  1100 DFDEIISEERFR-QLEKIKTIGSTYMAASGLNASTY----------------------------- 1134

  Fly   944 GSTEDDEMSGDNVSQPYAQVQDVAVLVMTEFALDLLRIMHDIRYNYVFSEYDTFLTGSLKIGISH 1008
                      |.|.:.:       :..:.::|:.|:..|..|. .:.|:.:      .:|||::.
Mouse  1135 ----------DQVGRSH-------ITALADYAMRLMEQMKHIN-EHSFNNF------QMKIGLNM 1175

  Fly  1009 GSVMAGVVGLSKPHYDIWGHTVNMASRMSSTGLLDNIQVTRHTAKVL--RQFNIRCNYRGHTEVK 1071
            |.|:|||:|..||.|||||:|||::|||.|||:.|.||||....:||  :.:.:.|  ||..:||
Mouse  1176 GPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLEC--RGVVKVK 1238

  Fly  1072 GVGKVPTYLV 1081
            |.|::.||.:
Mouse  1239 GKGEMTTYFL 1248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	77/200 (39%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	66/155 (43%)
		CYCc	814..1056	CDD:214485	85/254 (33%)
		Nucleotidyl_cyc_III	845..1081	CDD:299850	84/247 (34%)
Adcy6	XP_006520366.3	AC_N	83..454	CDD:318454	49/242 (20%)
		Guanylate_cyc	456..640	CDD:306677	74/187 (40%)
		DUF1053	668..754	CDD:368844	16/112 (14%)
		Guanylate_cyc	1056..1250	CDD:306677	84/249 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910