Protein Alignment CG32305 and ADCY9

DIOPT Version :9

• Sequence 1: NP_728725.2
• Gene: CG32305 / 317967
• FlyBaseID: FBgn0052305
• Length: 1164
• Species: Drosophila melanogaster
• Sequence 2: XP_005255136.1
• Gene: ADCY9 / 115
• HGNCID: 240
• Length: 1372
• Species: Homo sapiens
• Alignment Length: 1420
• Identity: 321/1420 - (22%)
• Similarity: 528/1420 - (37%)
• Gaps: 454/1420 - (31%)

  Fly    32 KCQNLRLELAC---------SRLRELALMSNVVQIIWHVE---------LLMVAHVILLLALVKD 78
            |..::.||.||         .|.|..........::|.:.         ::|||..:..|.:...
Human    94 KFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVG 158

  Fly    79 IILVTMVPYFA--------VMLFSPFIMLLSMQNNVGMITNTLISWLMALFLTSMDLVSDLLGTI 135
            ..|.|....:|        .:....|.:.|:.|..|               ||.:....|  .:.
Human   159 FFLFTFTKLYARHYAWTSLALTLLVFALTLAAQFQV---------------LTPVSGRGD--SSN 206

  Fly   136 YSGAAYPTVPCYDHV--------VLVSVYMTLPIAFYQGSSVYVLGMVVSIIY--IGY------- 183
            .:..|.||..|...|        ||..:|..:.:..|..   ..||:..|:::  .||
Human   207 LTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLS---LCLGVAYSVLFETFGYHFRDEAC 268

  Fly   184 -------AFYMQYLNDQVSFYLLASYAIYLFTLNLIFSFFTIIRDYGLRRAILSRYQLVYQNIVY 241
                   |.:.:.|:..:....:.:..::||.::.:.|..|.::              |.|:|::
Human   269 FPSPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLK--------------VGQSIMH 319

  Fly   242 QLVMKKENGLLESILPRKMIRTLQEEICSRIEDQDKNFTPSKA------------------GLRK 288
            ...::.|..|.|.::...|.|.:.:::..:.:::.:|.....|                  ..|.
Human   320 GKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRP 384

  Fly   289 LFLEPYPNVSILVADMVNYTHLTTTLEAPQLVEILHDLFVNFDLAANRNRAMRIKFLGDSYNCVA 353
            ..::....||||.||:|.:|.::....|..||.:|:|||..||......:..:|..|||.|.|||
Human   385 FKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVA 449

  Fly   354 GIPNYFPAHASCCVDQALEMIH-ITQGVSSRRELDINLRIGVHSGEVFAGIIGHTKWQFDIWSKD 417
            |.|.....||.||::..|.||. |.|....::|: :|:|:|||:|.|..||:|..:::||:||.|
Human   450 GCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEM-VNMRVGVHTGTVLCGILGMRRFKFDVWSND 513

  Fly   418 VDITNRLESSGLPGLVHVSQRTLSMLDEHYIFREG--TEAAKNDPILQQ-AGIRTFLVSNR---- 475
            |::.|.:|..|:.|.||:|:.|...||:.|...:|  .|......:..| .|::|:|:|.:
Human   514 VNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKE 578

  Fly   476 ---------------------------------------------------LPD----------- 478
                                                               .|.
Human   579 SRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKTFDNLKTCPSCGITFAPKSEA 643

  Fly   479 -----AVEPGELDDELSSASINSCRLSY-------------GG------------YYEEIQIKAQ 513
                 |.:.|..|:..:|..:.|..|.:             ||            ..||....:|
Human   644 GAEGGAPQNGCQDEHKNSTKVTSSWLLFLSVPLLAHPPKASGGPNPKTQNGLLSPPQEEKLTNSQ 708

  Fly   514 R---EIMKE--------VDQMAV-------------GHCFIEWRRSSSMKKQDFNEEYLFS---N 551
            .   ||::|        :||.|:             .| |::..:..|:.|     :|.|.   |
Human   709 TSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAH-FVDVIKEDSLMK-----DYFFKPPIN 767

  Fly   552 QIHLVL---GVFRSWKREWE----------------FHNLPDLMIKYTMLLVL---C-------- 586
            |..|..   .:.||::..::                |.:|.|:.:..|:.|.|   |
Human   768 QFSLNFLDQELERSYRTSYQEEVIKNSPVKTFASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAAT 832

  Fly   587 -----AGLAIMSINLIEEATYPDILVLLGILLILLILCILAGYKKLRLQWKKLTPMSQPSCFLSR 646
                 |.||:.|..|:.|.    :.:.:.|.::..:..::|..|:| |:|            ::.
Human   833 VPPPPAALAVFSAALLLEV----LSLAVSIRMVFFLEDVMACTKRL-LEW------------IAG 880

  Fly   647 WLLRISERIEDSLFVRIPLTMVVLLLLYVMSSQAVFSCDVAKLELSIIEAHLYNEKSYAECFGPW 711
            ||.|   ....::.|.:|             :.||:|...::.|.:|   |          |..:
Human   881 WLPR---HCIGAILVSLP-------------ALAVYSHVTSEYETNI---H----------FPVF 916

  Fly   712 TVTYCVVIVI--------------SLLFVVPGCPLV---IKILAGLLILGLHLGTVHLYYGFAFE 759
            |.:..::.|:              ||..||...||:   :.:.....:|...|..|.   .|:.|
Human   917 TGSAALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQ---NFSSE 978

  Fly   760 R-----SETTDLGLKSDYAHTWYLVALFIVLVLRERHVNYL-RKFNYFMRVCYEEAHQQTDEKLR 818
            |     |...||...:.......::..|::|:|    |.:| |:|....|:.|   |...:..|.
Human   979 RNPCNSSVPRDLRRPASLIGQEVVLVFFLLLLL----VWFLNREFEVSYRLHY---HGDVEADLH 1036

  Fly   819 SIKI---------IMANILPTHVAQVYKVRRPHDQLYYENFSKVAVMFASI--------ENFNAD 866
            ..||         ::.||:|.|||:..||    .|.|.:|.....|:||||        ||:...
Human  1037 RTKIQSMRDQADWLLRNIIPYHVAEQLKV----SQTYSKNHDSGGVIFASIVNFSEFYEENYEGG 1097

  Fly   867 TAGLRILHEIICCFDDLL--VDYQTRYKIEKIKVMGWTYMVACGLETDHYTDFSIDIPVKQPEAD 929
            ....|:|:|:|..||:||  .||.:   |||||.:|.|||.|.||.|....|
Human  1098 KECYRVLNELIGDFDELLSKPDYSS---IEKIKTIGATYMAASGLNTAQAQD------------- 1146

  Fly   930 SEIRRGSSVLTVHFGSTEDDEMSGDNVSQPYAQVQDVAVLVMTEFALDLLRIMHDIRYNYVFSEY 994
                                      .|.|...:|     ::.|||.:::|::.|...|.::..:
Human  1147 --------------------------GSHPQEHLQ-----ILFEFAKEMMRVVDDFNNNMLWFNF 1180

  Fly   995 DTFLTGSLKIGISHGSVMAGVVGLSKPHYDIWGHTVNMASRMSSTGLLDNIQVTRHTAKVLRQFN 1059
                  .|::|.:||.:.|||:|.:|..|||||.|||:||||.:||:...|||:..:.:||.:..
Human  1181 ------KLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMG 1239

  Fly  1060 IRCNYRGHTEVKGVGKVPTYL--------------VVVDPDLTFQDHDQVSMSMKDS------KS 1104
            ...:|||...|||.|::.|||              :.:.||:..|....:..|..|.      ..
Human  1240 YDFDYRGTVNVKGKGQMKTYLYPKCTDHRVIPQHQLSISPDIRVQVDGSIGRSPTDEIANLVPSV 1304

  Fly  1105 WVIDTLSLSFTPS------FVPPKSSTSDEEEAE--GELEENVSEGDELEVSIHE 1151
            ..:|..||....|      .:.||....:..:||  |...:.:.:.|..|..|.|
Human  1305 QYVDKTSLGSDSSTQAKDAHLSPKRPWKEPVKAEERGRFGKAIEKDDCDETGIEE 1359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	71/216 (33%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	62/153 (41%)
		CYCc	814..1056	CDD:214485	81/260 (31%)
		Nucleotidyl_cyc_III	845..1081	CDD:299850	80/259 (31%)
ADCY9	XP_005255136.1	DUF2339	<118..>301	CDD:287113	33/202 (16%)
		CYCc	326..544	CDD:214485	71/218 (33%)
		Guanylate_cyc	385..573	CDD:278633	70/188 (37%)
		CYCc	1043..1243	CDD:214485	79/256 (31%)
		Guanylate_cyc	1069..1260	CDD:278633	78/243 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810