Protein Alignment CG32305 and ADCY8

DIOPT Version :10

• Sequence 1: NP_728725.2
• Gene: CG32305 / 317967
• FlyBaseID: FBgn0052305
• Length: 1164
• Species: Drosophila melanogaster
• Sequence 2: NP_001106.1
• Gene: ADCY8 / 114
• HGNCID: 239
• Length: 1251
• Species: Homo sapiens
• Alignment Length: 1154
• Identity: 302/1154 - (26%)
• Similarity: 515/1154 - (44%)
• Gaps: 229/1154 - (19%)

  Fly    29 LKNKCQNLRLELACSRL-----RELALMSNVVQIIWHVELLMVAHVILLLALVKDI--ILVTMVP 86
            |:|..::..||....|.     |:..::.||:.::..:.|| |.|:.|..|.:..:  ||:....
Human   157 LRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLL-VLHLSLASAPMDPLKGILLGFFT 220

  Fly    87 YFAVMLFSPFIMLLSMQNNVGMITNTLISWLMALFLTSMDLVSDL-LGTIYSGAAYPTVPCYDHV 150
            ...|::.:..::.....::..:..:.:::|:.   :|:..|.:.| .|.:..|..|..      .
Human   221 GIEVVICALVVVRKDTTSHTYLQYSGVVTWVA---MTTQILAAGLGYGLLGDGIGYVL------F 276

  Fly   151 VLVSVYMTLPI----AFYQGSSVYVLGMVVSIIYIGYAFYMQYLNDQVSFYLLASYAIYLFTLNL 211
            .|.:.|..||:    |...|....:|.:::.::....|.        :|...:.:.|:....:|.
Human   277 TLFATYSMLPLPLTWAILAGLGTSLLQVILQVVIPRLAV--------ISINQVVAQAVLFMCMNT 333

  Fly   212 IFSFFTIIRDYGLRRAILSRYQLVYQNIVYQLVMKKENGLLESILPRKMIRTLQEEICSRIEDQD 276
            ...|.:.:.|...|:|.|...:.|...:..:...:::..|:.|:|||.::..:..:: :.:||:.
Human   334 AGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDM-TNVEDEH 397

  Fly   277 KNFTPSKAGLRKLFLEPYPNVSILVADMVNYTHLTTTLEAPQLVEILHDLFVNFDLAANRNRAMR 341
            ....     ..::::..|.|||||.||:..:|:|:|||.|.:||.:|::||..||..|:.:..:|
Human   398 LQHQ-----FHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLR 457

  Fly   342 IKFLGDSYNCVAGIPNYFPAHASCCVDQALEMIHITQGVSSRRELDINLRIGVHSGEVFAGIIGH 406
            ||.|||.|.||:|:|.....||.|||:..|.||...:.|.||.:.|:::|||:|||.|..|::|.
Human   458 IKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGL 522

  Fly   407 TKWQFDIWSKDVDITNRLESSGLPGLVHVSQRTLSMLDEHYIFREGTEAAKNDPILQQAGIRTFL 471
            .|||||:||.||||.|:|||.|:||.:|:|:.||..|:..|...||....:|: .|::..|.|:|
Human   523 RKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNE-FLRKHNIETYL 586

  Fly   472 VSN------RLPDAV-----------------EPGELDDELSSASI------------NSCRLSY 501
            :..      .||:.:                 ..|....||...:|            ||..|..
Human   587 IKQPEDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLP 651

  Fly   502 GGYYEEIQIKA-QREIMKEVDQMAVGHCFIEWRRSSSMKKQDFNEEYLFSNQIHLVLGVFRSWKR 565
            ....:.:.::: ..||.|.::..      |:.|....::::......|          :|:....
Human   652 NHLAQALHVQSGPEEINKRIEHT------IDLRSGDKLRREHIKPFSL----------MFKDSSL 700

  Fly   566 EWEFHNLPDLMIKYTMLLVLCAGLAIMSINLIE-----EATYP-----DILVLLGILLILLILCI 620
            |.::..:.|.:.|..:   :||.:.::.|..|:     ....|     .||::|...|:|:...
Human   701 EHKYSQMRDEVFKSNL---VCAFIVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTA- 761

  Fly   621 LAGYKKLRLQWKKLTPMSQPSCFLSRWLLRISERIEDSLFVRIPLTMVVLLLLYVMSSQAVFSCD 685
             ..||.|.|..:|       :|.   |       |.::...|..:....:|:.::.:...:..||
Human   762 -EDYKCLPLILRK-------TCC---W-------INETYLARNVIIFASILINFLGAILNILWCD 808

  Fly   686 VAKLELSIIEAHL-YNEK-------SYAECF---GPWTVTYCVVIVISLLFVVPGCPLVIKILAG 739
            ..|   ||...:| :|..       ||.|.|   |...:..|.|.:        ....|:|:...
Human   809 FDK---SIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFL--------RLNSVLKLAVL 862

  Fly   740 LLILGLHLGTVHLYYGFAFERSETTD------LGLKSDYAHTWYLVALFIVLVL-RERHVNYLRK 797
            |:::.::.......|...|.|.:..:      ||.|.   .:..|:|:|::.|. ..:.:.|..:
Human   863 LIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKE---VSLLLMAMFLLAVFYHGQQLEYTAR 924

  Fly   798 FNYFMRVCYEEAHQQTDEKLRSIKIIMANILPTHVAQVYKVR-RPHDQLYYENFSKVAVMFASIE 861
            .::..||..:|...:..|.....:.::.||||:|||:.:..: |.:::||.:::..|.||||||.
Human   925 LDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIP 989

  Fly   862 NF----------NADTAGLRILHEIICCFDDLLVDYQTRYK-IEKIKVMGWTYMVACGLETDHYT 915
            .|          |.....||:|:|||..||:||  .:.|:: |||||.:|.|||...||.
Human   990 GFADFYSQTEMNNQGVECLRLLNEIIADFDELL--GEDRFQDIEKIKTIGSTYMAVSGLS----- 1047

  Fly   916 DFSIDIPVKQPEADSEIRRGSSVLTVHFGSTEDDEMSGDNVSQPYAQVQDV--AVLVMTEFALDL 978
                  |.||                                    |.:|.  .:..:.:|:|.|
Human  1048 ------PEKQ------------------------------------QCEDKWGHLCALADFSLAL 1070

  Fly   979 LRIMHDIRYNYVFSEYDTFLTGSLKIGISHGSVMAGVVGLSKPHYDIWGHTVNMASRMSSTGLLD 1043
            ...:.:|. .:.|:.::      |:||||||||:|||:|..||.|||||.|||:||||.|||:..
Human  1071 TESIQEIN-KHSFNNFE------LRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSG 1128

  Fly  1044 NIQVTRHTAKVLRQFNIRCNYRGHTEVKGV----GKVPTYLVV--VDPD 1086
            .|||...|..:|:......:|||...|||:    ||:.||.::  |.|:
Human  1129 RIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPN 1177

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	AcyC	62..451	CDD:441717	118/395 (30%)
		Nucleotidyl_cyc_III	292..445	CDD:448371	77/152 (51%)
		Nucleotidyl_cyc_III	845..1081	CDD:448371	88/252 (35%)
ADCY8	NP_001106.1	Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250|UniProtKB:P40146	1..182		6/24 (25%)
		Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250|UniProtKB:P40146	1..109
		Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146	38..40
		Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146	49..51
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	50..92
		AcyC	214..567	CDD:441717	112/375 (30%)
		Guanylate_cyc	405..589	CDD:425528	85/184 (46%)
		Adcy_cons_dom	617..712	CDD:461877	16/110 (15%)
		Guanylate_cyc	973..1172	CDD:425528	88/254 (35%)
		Involved in CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146	1109..1251		31/69 (45%)
		Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250|UniProtKB:P40146	1200..1215
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1223..1251