DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32305 and Gucy2e

DIOPT Version :9

Sequence 1:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster
Sequence 2:	NP_570093.2	Gene:	Gucy2e / 113911	RGDID:	69322	Length:	1123	Species:	Rattus norvegicus

Alignment Length:	308	Identity:	81/308 - (26%)
Similarity:	141/308 - (45%)	Gaps:	59/308 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 TLNLIFSFF--------TIIRDYGLRRAILSRYQLVYQNIV------YQLVMKKENGLLESILPR 258
            :|:.|::.|        |.:.|..||  :|.:|....:.:|      .:|..:|...||..:||
  Rat   810 SLDQIYTQFKSINQGKKTSVADSMLR--MLEKYSQSLEGLVQERTEELELERRKTERLLSQMLP- 871

  Fly   259 KMIRTLQEEICSRIEDQDKNFTPSKAGLRKL--FLEP--YPNVSILVADMVNYTHLTTTLEAPQL 319
                                  ||.|...|:  .:||  :..|:|..:|:|.:|.::...|..::
  Rat   872 ----------------------PSVAHALKMGTTVEPEYFDQVTIYFSDIVGFTTISALSEPIEV 914

  Fly   320 VEILHDLFVNFDLAANRNRAMRIKFLGDSYNCVAGIP----NYFPAHASCCVDQALEMIHITQGV 380
            |..|:||:..||...:.:...:::.:||:|...:|:|    |   .||:...:.|||::......
  Rat   915 VGFLNDLYTMFDAVLDSHDVYKVETIGDAYMVASGLPRRNGN---RHAAEIANMALEILSYAGNF 976

  Fly   381 SSRRELDINLRI--GVHSGEVFAGIIGHTKWQFDIWSKDVDITNRLESSGLPGLVHVSQRT---L 440
            ..|...|:.:|:  |:|||...||::|.|..::.::...|:..:|:||:|||..:|||:.|   |
  Rat   977 RMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSRNTVQAL 1041

  Fly   441 SMLDEHY-IFREGTEAAKNDPILQQ---AGIRTFLVSNRLPDAVEPGE 484
            ..|||.| |...|....|...:.:.   .|...|..|...|.:::||:
  Rat  1042 LSLDEGYKIDVRGQTELKGKGLEETYWLTGKTGFCRSLPTPLSIQPGD 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	60/211 (28%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	49/163 (30%)
		CYCc	814..1056	CDD:214485
		Nucleotidyl_cyc_III	845..1081	CDD:299850
Gucy2e	NP_570093.2	PBP1_sensory_GC_DEF-like	71..445	CDD:380594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..556
		PK_GC-2D	554..824	CDD:270945	3/13 (23%)
		CYCc	861..1050	CDD:214485	61/214 (29%)
		Interaction with NCALD. /evidence=ECO:0000269\|PubMed:18178149	880..921		10/40 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900