Protein Alignment CG32305 and ADCY7

DIOPT Version :9

• Sequence 1: NP_728725.2
• Gene: CG32305 / 317967
• FlyBaseID: FBgn0052305
• Length: 1164
• Species: Drosophila melanogaster
• Sequence 2: XP_011521137.1
• Gene: ADCY7 / 113
• HGNCID: 238
• Length: 1086
• Species: Homo sapiens
• Alignment Length: 1146
• Identity: 298/1146 - (26%)
• Similarity: 491/1146 - (42%)
• Gaps: 268/1146 - (23%)

  Fly    45 LRELALMSNVVQIIWHVELLMVAHVILLLALVKDIILVTMVPYFAVMLFSPFIML-LSMQNNVGM 108
            ||.|||::      |.. |:.:.:|::..|..|.......||:|..::|..:.:| .||:..|.:
Human    93 LRALALLT------WAC-LVALGYVLVFDAWTKAACAWEQVPFFLFIVFVVYTLLPFSMRGAVAV 150

  Fly   109 ITNTLISWLMALFLTSMDLVSDLLGTIYSGAAYPTVPCYDHVVLVSVYMTLPIAFYQGSSVYVLG 173
            ...:..|.|:            :||::..|...|:|             .:.:.....:.:::.|
Human   151 GAVSTASHLL------------VLGSLMGGFTTPSV-------------RVGLQLLANAVIFLCG 190

  Fly   174 MVVSIIYIGYAFYMQYLNDQVSFYLLASYAIYLFTLNLIFSFFTIIRDYGLRRAILSRYQLVYQN 238
            .:..      ||:...:.|       ||..::.:|:..|          .:||.:
Human   191 NLTG------AFHKHQMQD-------ASRDLFTYTVKCI----------QIRRKL---------- 222

  Fly   239 IVYQLVMKKENGLLESILPRKMIRTLQEEICSRIEDQ-DKNFTPSKAGLRKLFLEPYPNVSILVA 302
               ::..:::..||.|:||..:...::..|..|:::. |:...|.. ....|:::.:.|||||.|
Human   223 ---RIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDN-NFHSLYVKRHQNVSILYA 283

  Fly   303 DMVNYTHLTTTLEAPQLVEILHDLFVNFDLAANRNRAMRIKFLGDSYNCVAGIPNYFPAHASCCV 367
            |:|.:|.|.:.....:||.:|::||..||..|..|..||||.|||.|.||:|:|...|.||..||
Human   284 DIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCV 348

  Fly   368 DQALEMIHITQGVSSRRELDINLRIGVHSGEVFAGIIGHTKWQFDIWSKDVDITNRLESSGLPGL 432
            ...|:|....:.|.....:|||:|:|:|||.|..|:||..|||:|:||.||.:.||:|::|:||.
Human   349 KMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGR 413

  Fly   433 VHVSQRTLSMLDEHYIFREGTEAAKNDPILQQAGIRTFLVSNRLPDAVEPGELDDEL-------- 489
            ||:::.||..||:.|...:| ...:.||.|::..|||:||.:  |.:.:|......|
Human   414 VHITEATLKHLDKAYEVEDG-HGQQRDPYLKEMNIRTYLVID--PRSQQPPPPSQHLPRPKGDAA 475

  Fly   490 --SSASINSCRL--SYG--------GYYEEIQI----------------------------KAQR 514
              ..||:...|.  |:|        .:.|.:..                            |.:.
Human   476 LKMRASVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRS 540

  Fly   515 EIMKEVDQMAVGHCFIEWRRSSSMKKQDFNEEYLFSNQIHLVLGVF--RSWKREWEFHNLPDLMI 577
            |.....|:|......:...|....|..||   |.|.:       :|  :.::||:....:|....
Human   541 EDDSYDDEMLSAIEGLSSTRPCCSKSDDF---YTFGS-------IFLEKGFEREYRLAPIPRARH 595

  Fly   578 KYTMLLVLCAGLAIMSINLIEEATYPDILVL-LGILLILLILCILAGYKKLRLQWKKLTPMSQPS 641
            .:.     ||.|..:.|.|:.....|....| :...|:..:|.::.|.
Human   596 DFA-----CASLIFVCILLVHVLLMPRTAALGVSFGLVACVLGLVLGL----------------- 638

  Fly   642 CFLSRW---------LLRISERIEDSLFVRIPLTMVVLLLLYVMSSQAVFSCDVAKLELSIIEAH 697
            ||.:::         |..||||:|..     ||..:.|.:|.:.|...|...::..:...:.|..
Human   639 CFATKFSRCCPARGTLCTISERVETQ-----PLLRLTLAVLTIGSLLTVAIINLPLMPFQVPELP 698

  Fly   698 LYNE--------KSYAECFG-PWTVTYCVVIVISL-----LFVVPGCPLVIKILAGLLIL----- 743
            :.||        |:.|.|.. |:....||:..|:.     :.:.|...|:...|...|:|
Human   699 VGNETGLLAASSKTRALCEPLPYYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSP 763

  Fly   744 -------GLHLGTVHLYYGFAFERSETTDLGLKSDYAHT-WYLVALFIVLVLRERHVNYLRKFNY 800
                   |..||.:....|   ..|.|.....|.....| :|||..:|.|:...|.::|..:.:.
Human   764 CWQWDCCGQGLGNLTKPNG---TTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDC 825

  Fly   801 FMRVCYEEAHQQTDEKLRSIKIIMANILPTHVAQVYKVRRPHDQLYYENFSKVAVMFASIENF-- 863
            ..:..:::.|::.:......::::.|:||.|||..:...:.::..|::::..|.|||||:.:|
Human   826 LWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKV 890

  Fly   864 -----NADTAG---LRILHEIICCFDDLLVDYQTRYK-IEKIKVMGWTYMVACGLETDHYTDFSI 919
                 :.:..|   ||:|:|||..||:||:  :.::. :||||.:|.|||.|.||
Human   891 FYTECDVNKEGLECLRLLNEIIADFDELLL--KPKFSGVEKIKTIGSTYMAAAGL---------- 943

  Fly   920 DIPVKQPEADSEIRRGSSVLTVHFGSTEDDEMSGDNVSQPYAQVQDVAVLVMTEFALDLLRIMHD 984
                             ||.:.|    |:.|:          :.|...:.||.||::.|:..:..
Human   944 -----------------SVASGH----ENQEL----------ERQHAHIGVMVEFSIALMSKLDG 977

  Fly   985 IRYNYVFSEYDTFLTGSLKIGISHGSVMAGVVGLSKPHYDIWGHTVNMASRMSSTGLLDNI---- 1045
            |..:       :|.:..|::||:||.|:|||:|..||.|||||:|||:||||.|||.|..|
Human   978 INRH-------SFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVSL 1035

  Fly  1046 --QVTRHTAKVLRQFNIRCNYRGHTEVKGVGKVPTYLVVVD 1084
              |||..|..:|:.....|..||...|||.|::.||.|..|
Human  1036 PFQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCTD 1076

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	82/198 (41%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	70/152 (46%)
		CYCc	814..1056	CDD:214485	82/258 (32%)
		Nucleotidyl_cyc_III	845..1081	CDD:299850	86/252 (34%)
ADCY7	XP_011521137.1	AC_N	<73..249	CDD:292831	40/223 (18%)
		CYCc	224..429	CDD:214485	81/205 (40%)
		Guanylate_cyc	270..432	CDD:278633	73/161 (45%)
		DUF1053	485..592	CDD:283888	17/116 (15%)
		CYCc	848..1052	CDD:214485	83/253 (33%)
		Guanylate_cyc	871..1073	CDD:278633	86/251 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020