Protein Alignment CG32305 and ADCY6

DIOPT Version :9

• Sequence 1: NP_728725.2
• Gene: CG32305 / 317967
• FlyBaseID: FBgn0052305
• Length: 1164
• Species: Drosophila melanogaster
• Sequence 2: NP_001377760.1
• Gene: ADCY6 / 112
• HGNCID: 237
• Length: 1168
• Species: Homo sapiens
• Alignment Length: 1189
• Identity: 298/1189 - (25%)
• Similarity: 496/1189 - (41%)
• Gaps: 351/1189 - (29%)

  Fly    64 LMVAHVILLLALVKDIILVTMVP---YFAVMLFSP--FIMLLSMQNNVGMITNTLISWLMALFLT 123
            |::|.::||.|::.........|   |.|::..:.  |:.|:.:.|......:::  |:::.
Human   154 LLMAVLVLLTAVLLAFHAAPARPQPAYVALLACAAALFVGLMVVCNRHSFRQDSM--WVVSY--- 213

  Fly   124 SMDLVSDLLGTIYSG---AAYPTVP-----CYDHVVLVSVYMTLPIAFYQGSSVYVLGMVVSIIY 180
               :|..:|..:..|   ||.|..|     |....|.:: |..|||..   .:..:.|:.:|.::
Human   214 ---VVLGILAAVQVGGALAADPRSPSAGLWCPVFFVYIA-YTLLPIRM---RAAVLSGLGLSTLH 271

  Fly   181 I--------GYAFYMQYLNDQVSFYLLASYAIYLFTLNLIFSF---------FTIIRDYGLRRAI 228
            :        |.||..:.|...|..:|..:      .:.:...:         |...|.|     |
Human   272 LILAWQLNRGDAFLWKQLGANVLLFLCTN------VIGICTHYPAEVSQRQAFQETRGY-----I 325

  Fly   229 LSRYQLVYQNIVYQLVMKKENGLLESILPRKMIRTLQEEICSRIEDQDKNFTPSKAGLRKLFLEP 293
            .:|..|.::|       :::..||.|:||:.:...::|:|.::.||.         ...|::::.
Human   326 QARLHLQHEN-------RQQERLLLSVLPQHVAMEMKEDINTKKEDM---------MFHKIYIQK 374

  Fly   294 YPNVSILVADMVNYTHLTTTLEAPQLVEILHDLFVNFDLAANRNRAMRIKFLGDSYNCVAGIPNY 358
            :.|||||.||:..:|.|.:...|.:||..|::||..||..|..|..:|||.|||.|.||:|:|..
Human   375 HDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEA 439

  Fly   359 FPAHASCCVDQALEMIHITQGVSSRRE---LDINLRIGVHSGEVFAGIIGHTKWQFDIWSKDVDI 420
            ...||.|||:..::||   :.:|..||   :::|:|:|:|||.|..|::|..|||||:||.||.:
Human   440 RADHAHCCVEMGVDMI---EAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTL 501

  Fly   421 TNRLESSGLPGLVHVSQRTLSMLDEHYIFREGTEAAKNDPILQQAGIRTFLV------------- 472
            .|.:|:.|..|.:|:::.||..|:..|....|....:| ..|::..|.|||:
Human   502 ANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERN-AYLKEQHIETFLILGASQKRKEEKAM 565

  Fly   473 --------------------------------------------SNR-LPDAVEPGELDDELSSA 492
                                                        .|| ..||:.|.:..||..|.
Human   566 LAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSR 630

  Fly   493 SINSCRLSYGGYYEEIQIKAQREIMKEVDQMAVGHCFIEWRR-SSSMKKQDFNEEYLFSNQIHLV 556
            :|::                     :.:||:...|.    || ..:.:::|..::|  |.::...
Human   631 AIDA---------------------RSIDQLRKDHV----RRFLLTFQREDLEKKY--SRKVDPR 668

  Fly   557 LGVFRSWKREWEFHNLPDLMIKYTMLLVLCAGLAIMSINLIEEATYPDILVLLGI-----LLILL 616
            .|.:                       |.||.|....|..|:...:|...::|||     ||:|:
Human   669 FGAY-----------------------VACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLI 710

  Fly   617 ILCILAGYKKLRLQWKKLTPMSQPSC--FLSRWLLRISERIEDSLFVRIPLTMVVLLLLYVMSSQ 679
            .:.|.|.|                ||  ...:.|.|:|..|..|......:.:..:||::..:..
Human   711 TVLICAVY----------------SCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIA 759

  Fly   680 AVF--------SCDVAKLELS---IIEAHLYNEKSYA------ECFGPWTVTYC----------- 716
            .:|        ||....|.|:   |...|| .:.:|:      .|.|  |:..|
Human   760 NMFTCNHTPIRSCAARMLNLTPADITACHL-QQLNYSLGLDAPLCEG--TMPTCSFPEYFIGNML 821

  Fly   717 -------VVIVIS------LLFVVPGCPLVIKILAGL---------LILGLHLGTVHLYYGFAFE 759
                   |.:.||      ::||: |...::.:|.|.         |:||:|        |.| .
Human   822 LSLLASSVFLHISSIGKLAMIFVL-GLIYLVLLLLGPPATIFDNYDLLLGVH--------GLA-S 876

  Fly   760 RSETTD---------LGLKSDYAHTWYLVALFIVLVLRERHVNYLRKFNYFMRVCYEEAHQQTDE 815
            .:||.|         :.||  |.....|:...:.|.|..:.|....:.::..::......::.:|
Human   877 SNETFDGLDCPAAGRVALK--YMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEE 939

  Fly   816 KLRSIKIIMANILPTHVAQVYKVR-RPHDQLYYENFSKVAVMFASIENFN-------ADTAG--- 869
            .....:.::.||||..||..:..| |.:|:|||::...||||||||.||:       |:..|
Human   940 LQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVEC 1004

  Fly   870 LRILHEIICCFDDLLVDYQTRYKIEKIKVMGWTYMVACGLETDHYTDFSIDIPVKQPEADSEIRR 934
            ||:|:|||..||:::.:.:.| ::||||.:|.|||.|.||....|
Human  1005 LRLLNEIIADFDEIISEERFR-QLEKIKTIGSTYMAASGLNASTY-------------------- 1048

  Fly   935 GSSVLTVHFGSTEDDEMSGDNVSQPYAQVQDVAVLVMTEFALDLLRIMHDIRYNYVFSEYDTFLT 999
                               |.|.:.:       :..:.::|:.|:..|..|. .:.|:.:
Human  1049 -------------------DQVGRSH-------ITALADYAMRLMEQMKHIN-EHSFNNF----- 1081

  Fly  1000 GSLKIGISHGSVMAGVVGLSKPHYDIWGHTVNMASRMSSTGLLDNIQVTRHTAKVL--RQFNIRC 1062
             .:|||::.|.|:|||:|..||.|||||:|||::|||.|||:.|.||||....:||  :.:.:.|
Human  1082 -QMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLEC 1145

  Fly  1063 NYRGHTEVKGVGKVPTYLV 1081
              ||..:|||.|::.||.:
Human  1146 --RGVVKVKGKGEMTTYFL 1162

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	77/200 (39%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	66/155 (43%)
		CYCc	814..1056	CDD:214485	85/254 (33%)
		Nucleotidyl_cyc_III	845..1081	CDD:299850	84/247 (34%)
ADCY6	NP_001377760.1	AC_N	<16..368	CDD:318454	49/252 (19%)
		Guanylate_cyc	370..554	CDD:306677	74/187 (40%)
		DUF1053	582..668	CDD:399378	17/112 (15%)
		Guanylate_cyc	970..1164	CDD:306677	84/249 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910