DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32305 and ADCY2

DIOPT Version :9

Sequence 1:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster
Sequence 2:	NP_065433.2	Gene:	ADCY2 / 108	HGNCID:	233	Length:	1091	Species:	Homo sapiens

Alignment Length:	1163	Identity:	315/1163 - (27%)
Similarity:	519/1163 - (44%)	Gaps:	226/1163 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 MSNVVQIIWHVELLMVAHVILLLAL-------VKDII--LVTMVP-----YFAVMLF----SPFI 97
            ||....:|..:.|:::...:.|||:       |:|.:  |:| ||     :||:.:.    |.|.
Human    40 MSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLIT-VPTALAIFFAIFILVCIESVFK 103

  Fly    98 MLLSMQNNVGMITNTLISWLMALF---LTSMDLVSDLLGTIYSGAAYPTVPCYDHVVLVSVYMTL 159
            .||.:.:.|..|....:.:|...|   ::..|.||..|..|:  ..|..:|......:::..:|
Human   104 KLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIF--VVYTMLPFNMRDAIIASVLT- 165

  Fly   160 PIAFYQGSSVYVLGMVVSIIYIGYAFYMQYLNDQVSFYLLASYAIYLFTLNLIFSFFTIIRDYGL 224
                 ..|...||.:.:|....|        .:.:.:.:||:..|::.. ||..::...:.:..|
Human   166 -----SSSHTIVLSVCLSATPGG--------KEHLVWQILANVIIFICG-NLAGAYHKHLMELAL 216

  Fly   225 RRAILSRYQLVYQNIVYQLVMKKENGLLESILPRKMIRTLQEEICSRIEDQDKNFTPSKAGLRKL 289
            ::........:...|..:...:::..||.|:||..:...::.||..|::........:......|
Human   217 QQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNL 281

  Fly   290 FLEPYPNVSILVADMVNYTHLTTTLEAPQLVEILHDLFVNFDLAANRNRAMRIKFLGDSYNCVAG 354
            :::.:.|||||.||:|.:|.|.:.....:||.:|::||..||..|..|..||||.|||.|.||:|
Human   282 YVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSG 346

  Fly   355 IPNYFPAHASCCVDQALEMIHITQGVSSRRELDINLRIGVHSGEVFAGIIGHTKWQFDIWSKDVD 419
            :|...|.||..||...|:|....:.|.....:|||:|:|||||.|..|:||..|||:|:||.||.
Human   347 LPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVT 411

  Fly   420 ITNRLESSGLPGLVHVSQRTLSMLDEHYIFREGTEAAKNDPILQQAGIRTFLVSNRLPDAVEPGE 484
            :.|.:|:.|:||.||:|..||..|:..|...|| :....||.|:|..::|:.|.|...:...|..
Human   412 LANHMEAGGVPGRVHISSVTLEHLNGAYKVEEG-DGDIRDPYLKQHLVKTYFVINPKGERRSPQH 475

  Fly   485 -------LDDELSSASINSCRL--SYGGYYEEIQIKAQREIMKE-----VDQMAVGHCFIEWR-- 533
                   ||.....||:...|.  |:|.......:..:..:..|     ...:.:|....:.|
Human   476 LFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTL 540

  Fly   534 RSSSMKK---QDFNE-------------EYLFSNQIHLVLGVF--RSWKREWEFHNLPDLMIKYT 580
            |:.|.||   ::.||             ::|.|..|..:..:|  :..::|:....||  ..||
Human   541 RTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALP--AFKY- 602

  Fly   581 MLLVLCAGLAIMSINLIEEATYPDILVL---LGILLILLILCILAGYKKLRLQW-KKLTPMSQPS 641
              .|.||.|....|.:::....|...||   .|...:||...:...:....||. ||.:|
Human   603 --YVTCACLIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCSKKASP----- 660

  Fly   642 CFLSRWLLRISERIEDSLFVRIPLTMVVLLLLYVMSSQAVF---------------------SCD 685
              |..|||:.|..|.:..:.||.||::...::.:|   |||                     |..
Human   661 --LLMWLLKSSGIIANRPWPRISLTIITTAIILMM---AVFNMFFLSDSEETIPPTANTTNTSFS 720

  Fly   686 VAKLELSIIEA-HLYNEKSYAECFGPWTVTYCVVIVISLLFVVPGCPLVIKI------------L 737
            .:..:::|:.| :|:        |.|:.:..|::.:||       |.:.:::            |
Human   721 ASNNQVAILRAQNLF--------FLPYFIYSCILGLIS-------CSVFLRVNYELKMLIMMVAL 770

  Fly   738 AG--LLILGLHLGTVHLYYGFAFER----SETTDLGLKSDYAHTWYLVALFIVLVLRERHVNYLR 796
            .|  .::|..|...:..|....|||    .:...:|..|       |...||.|::..|...|..
Human   771 VGYNTILLHTHAHVLGDYSQVLFERPGIWKDLKTMGSVS-------LSIFFITLLVLGRQNEYYC 828

  Fly   797 KFNYFMRVCYEEAHQQTDEKLRSIKIIMANILPTHVAQVYKVRR-PHDQLYYENFSKVAVMFASI 860
            :.::..:..:::..::.:......::::.|:||.|||:.:..|. .:::||::::..|.||||||
Human   829 RLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASI 893

  Fly   861 ENF-------NADTAG---LRILHEIICCFDDLLVDYQTRYK-IEKIKVMGWTYMVACGLETDHY 914
            .:|       :.:..|   ||:|:|||..|||||  .:.::. :||||.:|.|||.|.||..
Human   894 PDFKEFYTESDVNKEGLECLRLLNEIIADFDDLL--SKPKFSGVEKIKTIGSTYMAATGLSA--- 953

  Fly   915 TDFSIDIPVKQPEADSEIRRGSSVLTVHFGSTEDDEMSGDNVSQPYAQVQDVAVLVMTEFALDLL 979
                  :|.::...:.|.:      .:|.|:                         |.|||..|:
Human   954 ------VPSQEHSQEPERQ------YMHIGT-------------------------MVEFAFALV 981

  Fly   980 RIMHDIRYNYVFSEYDTFLTGSLKIGISHGSVMAGVVGLSKPHYDIWGHTVNMASRMSSTGLLDN 1044
            ..:..|. .:.|:::      .|::||:||.|:|||:|..||.|||||:|||:||||.|||:||.
Human   982 GKLDAIN-KHSFNDF------KLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDK 1039

  Fly  1045 IQVTRHTAKVLRQFNIRCNYRGHTEVKGVGKVPTYLVVVDPDLTFQDHDQVSMSMKDS 1102
            ||||..|:.||:.....|..||...|||.|.:.||.|          :.::|.|:..|
Human  1040 IQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFV----------NTEMSRSLSQS 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	81/197 (41%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	71/152 (47%)
		CYCc	814..1056	CDD:214485	86/253 (34%)
		Nucleotidyl_cyc_III	845..1081	CDD:299850	89/246 (36%)
ADCY2	NP_065433.2	AC_N	<33..260	CDD:292831	48/237 (20%)
		CYCc	236..439	CDD:214485	80/202 (40%)
		Guanylate_cyc	281..465	CDD:278633	81/184 (44%)
		DUF1053	495..599	CDD:283888	19/105 (18%)
		CYCc	848..1056	CDD:214485	87/256 (34%)
		Guanylate_cyc	878..1077	CDD:278633	90/257 (35%)
		Interaction with GNAS. /evidence=ECO:0000250\|UniProtKB:P26769	905..922		7/16 (44%)
		Interaction with GNAS. /evidence=ECO:0000250\|UniProtKB:P26769	990..993		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5262
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.830