DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32305 and ADCY1

DIOPT Version :9

Sequence 1:NP_728725.2 Gene:CG32305 / 317967 FlyBaseID:FBgn0052305 Length:1164 Species:Drosophila melanogaster
Sequence 2:NP_066939.1 Gene:ADCY1 / 107 HGNCID:232 Length:1119 Species:Homo sapiens


Alignment Length:1148 Identity:313/1148 - (27%)
Similarity:508/1148 - (44%) Gaps:249/1148 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 LRLELACSRLRELALMSNVVQIIWHVELLMV-------------AHVILLLALVKDIILVTMVPY 87
            ||||.|.: |:.||::|.:...:...|||..             .|.:|.|||    ::||.|..
Human    54 LRLEQAAT-LKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCVLFLAL----LVVTNVRS 113

  Fly    88 FAVMLFSPFIMLLSMQNNVGMITNTLISWLMALFLTSMDLVSDLLGTIYSGAAYPTVPCYDHVVL 152
            ..|          .....||.:. .|.|...||......|.....|:  :|||........    
Human   114 LQV----------PQLQQVGQLA-LLFSLTFALLCCPFALGGPARGS--AGAAGGPATAEQ---- 161

  Fly   153 VSVYMTLPIAFYQGSSVYVLGMVVSIIYIGYAFYMQYLNDQVSFYL-----------LASYAIYL 206
             .|:..|.:.|..    |.|..|.|::.||:...:...:..|:..|           |.:.|:..
Human   162 -GVWQLLLVTFVS----YALLPVRSLLAIGFGLVVAASHLLVTATLVPAKRPRLWRTLGANALLF 221

  Fly   207 FTLNLIFSFFTIIRDYGLRRAILSRYQLVYQNIVYQLVMKKENGLLESILPRKMIRTLQEEICSR 271
            ..:|:...|..|:.:...|:|.|.....:...:..:...:|:..||.|:|||.:...::|:.   
Human   222 VGVNMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDF--- 283

  Fly   272 IEDQDKNFTPSKAGLRKLFLEPYPNVSILVADMVNYTHLTTTLEAPQLVEILHDLFVNFDLAANR 336
                   ..|.:....|::::.:.|||||.||:|.:|.|.:...|.:||::|::||..||..|..
Human   284 -------LKPPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATE 341

  Fly   337 NRAMRIKFLGDSYNCVAGIPNYFPAHASCCVDQALEMIHITQGVSSRRELDINLRIGVHSGEVFA 401
            |...|||.|||.|.||:|:......||.|||:..|:||.....|:...|:|:|:|:|:|:|.|..
Human   342 NHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLC 406

  Fly   402 GIIGHTKWQFDIWSKDVDITNRLESSGLPGLVHVSQRTLSMLDEHYIFREGTEAAKNDPILQQAG 466
            |::|..|||:|:||.||.:.|.:|::||||.||:::.||:.|:..|....|....:|. .|:...
Human   407 GVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNS-FLKTHN 470

  Fly   467 IRTFLVSNRLPDAVEPGELDDELSSASINSCRLSYGGY-YEEIQIKAQREIMK-EVDQMAVGHCF 529
            |.||.:.......:.||.:..::..|.    |:.:... |..:|:...|::.| |:....|..|.
Human   471 IETFFIVPSHRRKIFPGLILSDIKPAK----RMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCE 531

  Fly   530 IEWR----RSSSMKKQDFNEEYLFSNQIHLVLGV----------------------------FRS 562
            .:.:    |::|.|.:  |.....:|.::...|.                            ::.
Human   532 DDDKRRALRTASEKLR--NRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKH 594

  Fly   563 WKREWEFHNLPD----LMIKYTMLLVLCAGLAIMSINLIEEATYPDILVLLGILLILLILCILAG 623
            .:||.::|.|.|    ..:..|::|....||..:.|       :|..:|    :|:||:.||   
Human   595 VEREQKYHQLQDEYFTSAVVLTLILAALFGLVYLLI-------FPQSVV----VLLLLVFCI--- 645

  Fly   624 YKKLRLQWKKLTPMSQPSCFLSRWLLRIS-ERIED-----SLFVRIPLTMVVLLLLYVMSSQAVF 682
                              |||...:|.:. .|::.     ::.:|..|.:.:::|:|.::...|.
Human   646 ------------------CFLVACVLYLHITRVQCFPGCLTIQIRTVLCIFIVVLIYSVAQGCVV 692

  Fly   683 SC----DVAKLELSIIEAHLYNEKSYAECFGPWTVTY-----CVV--IVISLLFVVPGCPLVIKI 736
            .|    ..:|...|::......:::..... |...|:     |:|  :.:::.|.|...|.:| :
Human   693 GCLPWAWSSKPNSSLVVLSSGGQRTALPTL-PCESTHHALLCCLVGTLPLAIFFRVSSLPKMI-L 755

  Fly   737 LAGL---LILGLHLGTVHLYYGFAFERSETTDLGLKSDYAHTWYLVALFI---VLVLRERHVNYL 795
            |:||   .||.|.|.      |:.     .|..|..|..::. .:||:.:   .|.|..|.|:..
Human   756 LSGLTTSYILVLELS------GYT-----RTGGGAVSGRSYE-PIVAILLFSCALALHARQVDIR 808

  Fly   796 RKFNYFMRVCYEEAHQQTDEKLRSIKIIMANILPTHVAQVYKVRRPHD-QLYYENFSKVAVMFAS 859
            .:.:|......||..:..::.....:.|:.|:||.||||.:.:..|.: .|||:::|:|.|||||
Human   809 LRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFAS 873

  Fly   860 IENFN-------ADTAG---LRILHEIICCFDDLL-VDYQTRYK-IEKIKVMGWTYMVACGLETD 912
            |.|||       .:..|   ||:|:|||..||:|: .|:   || |||||.:|.|||.|.||   
Human   874 IPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDF---YKDIEKIKTIGSTYMAAVGL--- 932

  Fly   913 HYTDFSIDIPVKQPEADSEIRRGSSVLTVHFGSTEDDEMSGDNVSQPYAQVQDVAVLVMTEFALD 977
                    .|....:|...|   ||.|:                             .:.:||::
Human   933 --------APTSGTKAKKSI---SSHLS-----------------------------TLADFAIE 957

  Fly   978 LLRIMHDIRYNYVFSEYDTFLTGSLKIGISHGSVMAGVVGLSKPHYDIWGHTVNMASRMSSTGLL 1042
            :..::.:|.|    ..|:.|:   |::||:.|.|:|||:|..:|.|||||:|||:||||.|||:.
Human   958 MFDVLDEINY----QSYNDFV---LRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQ 1015

  Fly  1043 DNIQVTRHTAKVLRQFNIRCNY----RGHTEVKGVGKVPTYLV 1081
            ..||||....::||    ||.|    ||...|||.|::.||.:
Human  1016 GRIQVTEEVHRLLR----RCPYHFVCRGKVSVKGKGEMLTYFL 1054

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32305NP_728725.2 CYCc 251..449 CDD:214485 78/197 (40%)
Nucleotidyl_cyc_III 292..445 CDD:299850 68/152 (45%)
CYCc 814..1056 CDD:214485 89/254 (35%)
Nucleotidyl_cyc_III 845..1081 CDD:299850 93/251 (37%)
ADCY1NP_066939.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..28
AC_N <161..292 CDD:292831 28/149 (19%)
CYCc 258..453 CDD:214485 78/204 (38%)
Guanylate_cyc 294..476 CDD:278633 75/182 (41%)
Interaction with calmodulin. /evidence=ECO:0000250 493..520 5/30 (17%)
CYCc 826..1037 CDD:214485 94/267 (35%)
Guanylate_cyc 859..1056 CDD:278633 93/253 (37%)
Interaction with calmodulin. /evidence=ECO:0000250 1024..1047 10/26 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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