Protein Alignment CG32305 and ADCY1

DIOPT Version :10

• Sequence 1: NP_728725.2
• Gene: CG32305 / 317967
• FlyBaseID: FBgn0052305
• Length: 1164
• Species: Drosophila melanogaster
• Sequence 2: NP_066939.1
• Gene: ADCY1 / 107
• HGNCID: 232
• Length: 1119
• Species: Homo sapiens
• Alignment Length: 1148
• Identity: 313/1148 - (27%)
• Similarity: 508/1148 - (44%)
• Gaps: 249/1148 - (21%)

  Fly    36 LRLELACSRLRELALMSNVVQIIWHVELLMV-------------AHVILLLALVKDIILVTMVPY 87
            ||||.|.: |:.||::|.:...:...|||..             .|.:|.|||    ::||.|..
Human    54 LRLEQAAT-LKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCVLFLAL----LVVTNVRS 113

  Fly    88 FAVMLFSPFIMLLSMQNNVGMITNTLISWLMALFLTSMDLVSDLLGTIYSGAAYPTVPCYDHVVL 152
            ..|          .....||.:. .|.|...||......|.....|:  :|||........
Human   114 LQV----------PQLQQVGQLA-LLFSLTFALLCCPFALGGPARGS--AGAAGGPATAEQ---- 161

  Fly   153 VSVYMTLPIAFYQGSSVYVLGMVVSIIYIGYAFYMQYLNDQVSFYL-----------LASYAIYL 206
             .|:..|.:.|..    |.|..|.|::.||:...:...:..|:..|           |.:.|:..
Human   162 -GVWQLLLVTFVS----YALLPVRSLLAIGFGLVVAASHLLVTATLVPAKRPRLWRTLGANALLF 221

  Fly   207 FTLNLIFSFFTIIRDYGLRRAILSRYQLVYQNIVYQLVMKKENGLLESILPRKMIRTLQEEICSR 271
            ..:|:...|..|:.:...|:|.|.....:...:..:...:|:..||.|:|||.:...::|:.
Human   222 VGVNMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDF--- 283

  Fly   272 IEDQDKNFTPSKAGLRKLFLEPYPNVSILVADMVNYTHLTTTLEAPQLVEILHDLFVNFDLAANR 336
                   ..|.:....|::::.:.|||||.||:|.:|.|.:...|.:||::|::||..||..|..
Human   284 -------LKPPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATE 341

  Fly   337 NRAMRIKFLGDSYNCVAGIPNYFPAHASCCVDQALEMIHITQGVSSRRELDINLRIGVHSGEVFA 401
            |...|||.|||.|.||:|:......||.|||:..|:||.....|:...|:|:|:|:|:|:|.|..
Human   342 NHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLC 406

  Fly   402 GIIGHTKWQFDIWSKDVDITNRLESSGLPGLVHVSQRTLSMLDEHYIFREGTEAAKNDPILQQAG 466
            |::|..|||:|:||.||.:.|.:|::||||.||:::.||:.|:..|....|....:|. .|:...
Human   407 GVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNS-FLKTHN 470

  Fly   467 IRTFLVSNRLPDAVEPGELDDELSSASINSCRLSYGGY-YEEIQIKAQREIMK-EVDQMAVGHCF 529
            |.||.:.......:.||.:..::..|.    |:.:... |..:|:...|::.| |:....|..|.
Human   471 IETFFIVPSHRRKIFPGLILSDIKPAK----RMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCE 531

  Fly   530 IEWR----RSSSMKKQDFNEEYLFSNQIHLVLGV----------------------------FRS 562
            .:.:    |::|.|.:  |.....:|.::...|.                            ::.
Human   532 DDDKRRALRTASEKLR--NRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKH 594

  Fly   563 WKREWEFHNLPD----LMIKYTMLLVLCAGLAIMSINLIEEATYPDILVLLGILLILLILCILAG 623
            .:||.::|.|.|    ..:..|::|....||..:.|       :|..:|    :|:||:.||
Human   595 VEREQKYHQLQDEYFTSAVVLTLILAALFGLVYLLI-------FPQSVV----VLLLLVFCI--- 645

  Fly   624 YKKLRLQWKKLTPMSQPSCFLSRWLLRIS-ERIED-----SLFVRIPLTMVVLLLLYVMSSQAVF 682
                              |||...:|.:. .|::.     ::.:|..|.:.:::|:|.::...|.
Human   646 ------------------CFLVACVLYLHITRVQCFPGCLTIQIRTVLCIFIVVLIYSVAQGCVV 692

  Fly   683 SC----DVAKLELSIIEAHLYNEKSYAECFGPWTVTY-----CVV--IVISLLFVVPGCPLVIKI 736
            .|    ..:|...|::......:::..... |...|:     |:|  :.:::.|.|...|.:| :
Human   693 GCLPWAWSSKPNSSLVVLSSGGQRTALPTL-PCESTHHALLCCLVGTLPLAIFFRVSSLPKMI-L 755

  Fly   737 LAGL---LILGLHLGTVHLYYGFAFERSETTDLGLKSDYAHTWYLVALFI---VLVLRERHVNYL 795
            |:||   .||.|.|.      |:.     .|..|..|..::. .:||:.:   .|.|..|.|:..
Human   756 LSGLTTSYILVLELS------GYT-----RTGGGAVSGRSYE-PIVAILLFSCALALHARQVDIR 808

  Fly   796 RKFNYFMRVCYEEAHQQTDEKLRSIKIIMANILPTHVAQVYKVRRPHD-QLYYENFSKVAVMFAS 859
            .:.:|......||..:..::.....:.|:.|:||.||||.:.:..|.: .|||:::|:|.|||||
Human   809 LRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFAS 873

  Fly   860 IENFN-------ADTAG---LRILHEIICCFDDLL-VDYQTRYK-IEKIKVMGWTYMVACGLETD 912
            |.|||       .:..|   ||:|:|||..||:|: .|:   || |||||.:|.|||.|.||
Human   874 IPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDF---YKDIEKIKTIGSTYMAAVGL--- 932

  Fly   913 HYTDFSIDIPVKQPEADSEIRRGSSVLTVHFGSTEDDEMSGDNVSQPYAQVQDVAVLVMTEFALD 977
                    .|....:|...|   ||.|:                             .:.:||::
Human   933 --------APTSGTKAKKSI---SSHLS-----------------------------TLADFAIE 957

  Fly   978 LLRIMHDIRYNYVFSEYDTFLTGSLKIGISHGSVMAGVVGLSKPHYDIWGHTVNMASRMSSTGLL 1042
            :..::.:|.|    ..|:.|:   |::||:.|.|:|||:|..:|.|||||:|||:||||.|||:.
Human   958 MFDVLDEINY----QSYNDFV---LRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQ 1015

  Fly  1043 DNIQVTRHTAKVLRQFNIRCNY----RGHTEVKGVGKVPTYLV 1081
            ..||||....::||    ||.|    ||...|||.|::.||.:
Human  1016 GRIQVTEEVHRLLR----RCPYHFVCRGKVSVKGKGEMLTYFL 1054

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	AcyC	62..451	CDD:441717	121/412 (29%)
		Nucleotidyl_cyc_III	292..445	CDD:448371	68/152 (45%)
		Nucleotidyl_cyc_III	845..1081	CDD:448371	93/251 (37%)
ADCY1	NP_066939.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28
		AcyC	100..456	CDD:441717	117/391 (30%)
		Guanylate_cyc	294..476	CDD:425528	75/182 (41%)
		Interaction with calmodulin. /evidence=ECO:0000250	493..520		5/30 (17%)
		Guanylate_cyc	859..1056	CDD:425528	93/253 (37%)
		Interaction with calmodulin. /evidence=ECO:0000250	1024..1047		10/26 (38%)