Protein Alignment CG32305 and adcy4

DIOPT Version :10

• Sequence 1: NP_728725.2
• Gene: CG32305 / 317967
• FlyBaseID: FBgn0052305
• Length: 1164
• Species: Drosophila melanogaster
• Sequence 2: XP_002934331.3
• Gene: adcy4 / 100497212
• XenbaseID: XB-GENE-984909
• Length: 1072
• Species: Xenopus tropicalis
• Alignment Length: 1190
• Identity: 320/1190 - (26%)
• Similarity: 526/1190 - (44%)
• Gaps: 273/1190 - (22%)

  Fly    28 HLKNKCQNLRLELACSRLRELALMSNVVQIIWHVELLMVAHVILLLALVKDIILVT--------- 83
            |.:.:|:           :|..|.....::.....::::. ::::||:...:|::|
 Frog    11 HYRQRCE-----------KEGPLYETYYRLTQQYPVILLL-LLIVLAVCCALIIITFATGRTFSD 63

  Fly    84 ----MVPYFAVM-----LFSPFIMLLSMQNNVGMITNTLISWLMAL---FLTSMDLVS---DLLG 133
                :|..|..:     ||.|..:...:|..:.:|...::..|:.|   |:.:..|||   .:..
 Frog    64 NVGFLVTLFCALGVFSILFIPVCIKKVVQKCMQIIGVVILGCLVTLGYVFIFTSGLVSAWDQIYW 128

  Fly   134 TIYSGAAYPTVPCYDHVVLVSVYMTLPI----AFYQGSSVYVLGMVVSIIYIGYAFYMQYLNDQV 194
            |::              |::|:|..||:    |.:.|.|.:|..::|..:|:.....:.  .|.|
 Frog   129 TLF--------------VIISLYTMLPLGMKWAIFAGLSCFVAHIIVLSVYVSTVRLLP--RDDV 177

  Fly   195 SFYLLASYAIYLFTLNLIFSFFTIIRDYGLR-------RAILSRYQLVYQNIVYQLVMKKENGLL 252
            :..::|. |:.|...|:|..:...:.:..|:       ..|.||.:||.|.       :::..||
 Frog   178 ALQMIAD-AVILLCGNVIGGYHKCVTESALKDTYHEAINFIHSRLKLVSQE-------RQQERLL 234

  Fly   253 ESILPRKMIRTLQEEICSRIED---QDKNFTPSKAGLRKLFLEPYPNVSILVADMVNYTHLTTTL 314
            .||||..:...::.||..|:::   |.:|..    ....|:::.:.:||||.||:|.:|.|::..
 Frog   235 LSILPAYIATEMKAEIIERLKEKRPQPENTN----NFHNLYIKRHKDVSILYADIVGFTLLSSEC 295

  Fly   315 EAPQLVEILHDLFVNFDLAANRNRAMRIKFLGDSYNCVAGIPNYFPAHASCCVDQALEMIHITQG 379
            ...:||.:|::||..||..|..|..||||.|||.|.||:|:|.:.|.||..||...|:|....:.
 Frog   296 SPKELVLMLNELFGKFDQIAKDNECMRIKILGDCYYCVSGLPEFLPNHAKNCVLMGLDMCQAIRK 360

  Fly   380 VSSRRELDINLRIGVHSGEVFAGIIGHTKWQFDIWSKDVDITNRLESSGLPGLVHVSQRTLSMLD 444
            :.....:|||:|:|||||.|..|:||..|||:|:||.||.:.|.:|:.|:||.||:::.|||.|:
 Frog   361 LRKATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITEATLSHLE 425

  Fly   445 EHYIFREGTEAAKNDPILQQAGIRTFLVSNRLPDAVEP----GELDDELSS---------ASINS 496
            ..|...:.| .|:.|..|::..|:|:||       ::|    ||.:|.|.|         ||:..
 Frog   426 NEYEVEDAT-LAQRDLYLKENNIKTYLV-------IDPRANDGEAEDILPSKSAEVPKMRASVRM 482

  Fly   497 CRL--SYGG-------YYEEIQIKAQREIMKEVDQMAVGHCFIEWRRSSSMKKQDFNEEYLFSNQ 552
            .|.  |:|.       .:.:..:.....|...:| :.:......|.:..|...::.||. |..|.
 Frog   483 TRYLESWGAEKPFAHLSHRDSLVPEPHSISHSMD-LPMSPLSQTWSQEKSRSTRETNES-LNDNN 545

  Fly   553 IHL--VLGVFRSWKREWEF---------------HNLPDL-MIKYTMLLVLCAGLAIMSINLIEE 599
            .|:  ||...|.|||..:|               :.|.|| ..||   ...|. ..|.:.|.|.:
 Frog   546 FHIMEVLASQRQWKRSKDFNRITLYFNDKAAEKEYRLSDLPSFKY---YTACC-FFIFACNFIVQ 606

  Fly   600 ATYPDILVLLGI--------LLILLILCILAGYKKLRLQWKKLTPMSQPSCFLSRWLLRISERIE 656
            ..........||        .|:||..|......:..|:..:|.          .||..:|..:.
 Frog   607 ILVSHKNAAFGISYGISFFFFLLLLFTCFAGHLARCILKGPQLL----------HWLPSLSIALS 661

  Fly   657 DSLFVRIPLTMVVLLLLYVMSSQAVF--------SCDVAKLELSII----EAHLYNEKSYAECFG 709
            ...::|:||.:..:|.:.||   |||        :|.......|:.    ...||:...|..|
 Frog   662 SRPWLRVPLGVFTILTVLVM---AVFNLFFLPDNNCPQQSWNSSLSPDPEPQMLYSLPYYMYC-- 721

  Fly   710 PWTVTYCVVIVISLLFVVPGCP--LVIKILAGLLILGLHLGTVHLYYGFAFERSETTDLGLKSDY 772
                  |::.:::       |.  |::...|.|::|.:.|    :.|...|..   |...|...|
 Frog   722 ------CILGLLA-------CSAFLLMNFEAKLILLSIAL----VIYNVIFLE---THSWLSDCY 766

  Fly   773 AHTWYL----------------VALFI----VLVLRERHVNYLR-KFNYFMRVCYEEAHQQTDEK 816
            .:..|:                ::|||    :|.|..::..|.| .|.:..:...|....:|.|.
 Frog   767 VNWLYMNHSRPGILKEPKVMGSISLFIFFFTLLALSRQNEYYCRLDFLWKRKFKMERERIETMEN 831

  Fly   817 LRSIKIIMANILPTHVAQVY-KVRRPHDQLYYENFSKVAVMFASIENF-------NADTAG---L 870
            |.  ::::.|:||..|||.: ...|.::.|||:::..|.|:||||.:|       :.:..|   |
 Frog   832 LN--RVLLENVLPADVAQQFIGQNRRNEDLYYQSYDCVCVLFASIPDFKEFYTECDENHEGLECL 894

  Fly   871 RILHEIICCFDDLLVDYQTRY-KIEKIKVMGWTYMVACGLETDHYTDFSIDIPVKQPEADSEIRR 934
            |:|:|||..||:||  .:.:: .:||||.:|..||.|.||...
 Frog   895 RLLNEIIADFDELL--SKPKFSSVEKIKTIGSAYMAATGLNAT---------------------- 935

  Fly   935 GSSVLTVHFGSTEDDEMSGDNVSQPYAQVQDVAVLVMTEFALDLLRIMHDIRYNYVFSEYDTFLT 999
                      |.:::...||   :.|..:.     :|.|||:.|:..: |:...:.|:.:
 Frog   936 ----------SGQENPQDGD---RNYNHIG-----IMVEFAIALIGKL-DLINKHSFNNF----- 976

  Fly  1000 GSLKIGISHGSVMAGVVGLSKPHYDIWGHTVNMASRMSSTGLLDNIQVTRHTAKVLRQFNIRCNY 1064
             .|::||:||.|:|||:|..||.|||||:|||:||||.|||:|..||||..|.|||.:...:|..
 Frog   977 -KLRVGINHGPVVAGVIGAQKPQYDIWGNTVNVASRMDSTGVLGKIQVTEETTKVLEKLGYKCER 1040

  Fly  1065 RGHTEVKGVGKVPTYLVVVD 1084
            ||..:|||.|::.||.|..|
 Frog  1041 RGVIKVKGKGQLCTYFVSTD 1060

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	AcyC	62..451	CDD:441717	125/426 (29%)
		Nucleotidyl_cyc_III	292..445	CDD:448371	69/152 (45%)
		Nucleotidyl_cyc_III	845..1081	CDD:448371	87/246 (35%)
adcy4	XP_002934331.3	AC_N	<17..250	CDD:318454	51/268 (19%)
		Guanylate_cyc	270..453	CDD:425528	79/190 (42%)
		Adcy_cons_dom	483..588	CDD:461877	22/106 (21%)
		Guanylate_cyc	859..1057	CDD:425528	87/246 (35%)