DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32305 and gucy1a2

DIOPT Version :9

Sequence 1:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster
Sequence 2:	XP_009290254.2	Gene:	gucy1a2 / 100330875	ZFINID:	ZDB-GENE-121023-3	Length:	608	Species:	Danio rerio

Alignment Length:	403	Identity:	102/403 - (25%)
Similarity:	173/403 - (42%)	Gaps:	63/403 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 FLTSMDLVSDLLGTIYSGAAYPTVPC-YDHVVL-VSVYMTL---PIAFYQGSSVYVLGMVVSIIY 180
            |..|.:|||            |.:|| :.:::| :|...|:   |    .|||:.....|:.:
Zfish   235 FSNSFELVS------------PRIPCSFQNILLRLSTPFTIRTRP----DGSSLDCREKVMEL-- 281

  Fly   181 IGYAFYMQYLNDQVSFYLLASYAI----YLFTLNLIFSFFTIIRDYGLRRAILSRYQLVYQNIVY 241
               ...|.:|.:..|...|.|..:    .|....|..|...|   :...|.::    ||.:....
Zfish   282 ---KGQMLHLPESNSIMFLGSPRVDRLEELMGRGLHLSDIPI---HDATRDVI----LVGEQAKA 336

  Fly   242 QLVMKKENGLLESILPRKMIRTLQEEICSRIEDQDKNFTPSKAGLR-----KLFLEPYPNVSILV 301
            |..:||....|::.| .|..:.|:|| ..|..|...:..|.....|     .:..:.:.:|::|.
Zfish   337 QDGLKKRMDKLKATL-EKTHQALEEE-KRRTVDLLYSIFPGDVAQRLWQGLPVQAKKFDDVTMLF 399

  Fly   302 ADMVNYTHLTTTLEAPQLVEILHDLFVNFDLAANRNRAMRIKFLGDSYNCVA-GIPNYFPAHASC 365
            :|:|.:|.:.......|::.:|::|:..||.........:|:.:||:| ||| |:.....:||..
Zfish   400 SDIVGFTAVCAQCTPMQVISMLNELYTRFDYQCGILDVYKIETIGDAY-CVAGGLHRKIDSHAKP 463

  Fly   366 CVDQALEMIHITQGVSSRRELDINLRIGVHSGEVFAGIIGHTKWQFDIWSKDVDITNRLESSGLP 430
            ....||:|:.:::.|.:.....|.||||:|||.|.||::|....::.::..:|.:.::.||...|
Zfish   464 IALMALKMMELSEEVLTPDGKPIKLRIGIHSGSVLAGVVGVMMPRYCLFGNNVTLASKFESGSHP 528

  Fly   431 GLVHVSQRTLSML--DEHYIF--REGTEAAKNDPILQQAGIRTFLVSNRLPDAVEPGELDDELSS 491
            ..::||..|..:|  |..:.|  |...|...|.| .:..||..||         |.|:.....|.
Zfish   529 RCINVSPTTYQLLRDDRSFTFIPRSRQELPDNFP-KEIPGICYFL---------EAGKSQSHASL 583

  Fly   492 ASINSC---RLSY 501
            .|..|.   ::||
Zfish   584 TSTRSAPIRKVSY 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	55/205 (27%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	44/155 (28%)
		CYCc	814..1056	CDD:214485
		Nucleotidyl_cyc_III	845..1081	CDD:299850
gucy1a2	XP_009290254.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900