Protein Alignment CG32305 and adcy8

DIOPT Version :9

• Sequence 1: NP_728725.2
• Gene: CG32305 / 317967
• FlyBaseID: FBgn0052305
• Length: 1164
• Species: Drosophila melanogaster
• Sequence 2: NP_001137224.1
• Gene: adcy8 / 100148976
• ZFINID: ZDB-GENE-070912-197
• Length: 1225
• Species: Danio rerio
• Alignment Length: 1123
• Identity: 295/1123 - (26%)
• Similarity: 511/1123 - (45%)
• Gaps: 205/1123 - (18%)

  Fly    46 RELALMSNVVQIIWHVELLMVAHVILLLALVKDIILVTMVPYFA---VMLFSPFIMLLSMQNNVG 107
            |:..::.|::.::..:.|| |.| :.|.:...|.|...::.:|.   |::.:..::.....::..
Zfish   153 RKSVVVMNILDVVTKLTLL-VLH-LTLASTPMDPIKGMLLGFFTGIEVVICALVVVRKDTSSHGY 215

  Fly   108 MITNTLISWL-MALFLTSMDLVSDLLGTIYSGAAYPTVPCYDHVVLVSVYMT-----LPIAFYQG 166
            :..:..::|: ||..:.:..|...|||   .|..|         ||.:::.|     ||:.:
Zfish   216 LQYSGAVTWVAMATQILATGLGYGLLG---DGIGY---------VLFTLFATYSMLPLPLTW--- 265

  Fly   167 SSVYVLGMVVSIIYIGYAFYMQYL---NDQVSFYLLASYAIYLFTLNLIFSFFTIIRDYGLRRAI 228
              ..|.|::.|.::|.    :|.|   ..|:|...|.:..:....:|....|.:.:.|...|:|.
Zfish   266 --AIVAGLLTSALHIA----LQLLVPPRAQISTNQLLAQVLLFLCINTAGMFISYLSDRAQRQAF 324

  Fly   229 LSRYQLVYQNIVYQLVMKKENGLLESILPRKMIRTLQEEICSRIEDQDKNFTPSKAGLRKLFLEP 293
            |...:.:...:..:...:::..|:.|:|||.::..:..:: :.:||:.....     ..::::..
Zfish   325 LETRRCIEARLRLETENQRQERLVLSVLPRFVVLEMINDM-TNVEDETLQHQ-----FHRIYIHR 383

  Fly   294 YPNVSILVADMVNYTHLTTTLEAPQLVEILHDLFVNFDLAANRNRAMRIKFLGDSYNCVAGIPNY 358
            |.|||||.||:..:|:|:|||.|.:||.:|::||..||..|:.:..:|||.|||.|.||:|:|..
Zfish   384 YENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEP 448

  Fly   359 FPAHASCCVDQALEMIHITQGVSSRRELDINLRIGVHSGEVFAGIIGHTKWQFDIWSKDVDITNR 423
            .|.||.|||:..|.||...:.|.||.:.||::|||:|||.|..|::|..|||||:||.||||.|:
Zfish   449 RPDHAHCCVEMGLSMIKTIRYVRSRTKHDIDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANK 513

  Fly   424 LESSGLPGLVHVSQRTLSMLDEHYIFREGTEAAKNDPILQQAGIRTFLVSN------RLPDAV-- 480
            |||.|:||.:|:|:..|..|:..|...||....:|| .|::..|.|||:..      .||:.:
Zfish   514 LESGGIPGRIHISKAALDCLNGDYEVEEGHGKDRND-FLRRHNIETFLIKQPEESLLTLPEDIMR 577

  Fly   481 -EPGELDDELSSASINSCRLSYGGYYEEI---QIKAQREIMKEVDQMAV---------------G 526
             ...:.|...|:.|...     |.:..|:   .|..::..:..:.:.::               |
Zfish   578 DSTNQSDHRTSNTSFTE-----GTWSPELPFHNIVGKQNTLAALTRHSINLLPNHLAQALHVRAG 637

  Fly   527 HCFIEWRRSSSMKKQD---FNEEYLFSNQIHLVLGVFRSWKREWEFHNLPDLMIKYTMLLVLCAG 588
            ...|..|..|::..:.   ..:|::....:     .||....|.::..:.|.:.|..:   :||.
Zfish   638 SQEINARMQSTIALRSGDKLRQEHISPFSL-----TFREALLEHKYSQMRDEVFKSNL---VCAF 694

  Fly   589 LAIMSI----NLIEEATYPDILVLLGILLILLILCILA-----GYKKLRLQWKKLTPMSQPSCFL 644
            :.:..|    :|:..|....:|:...: ||||..|::.     .||.|.|..:|       :|.
Zfish   695 IVLFFITGIQSLLPSARMVTMLIQFSV-LILLHCCLVVVTTAEDYKCLPLVLRK-------ACC- 750

  Fly   645 SRWLLRISERIEDSLFVRIPLTMVVLLLLYVMSSQAVFSCDVAKLELSIIEAHLYNEKSYAE--- 706
              |       :.::...|..:..:.:|:.::.:...:..||..|      .....|:...|.
Zfish   751 --W-------VNETYAARNVVIFLSILINFLAAMINILWCDFDK------SGSFRNQTFNASASI 800

  Fly   707 ---CFGPWTVTYCVVIVISLLFVVPGCPLVIKILAGLLILGLHLGTVHLYYGFAFERSETTDLGL 768
               ||.|....:..|:.:....|......|:|:...|:::.::......:|...|.|.:|..|..
Zfish   801 PDICFYPEYFVFTGVLAMVTCAVFLRLNSVLKLAILLIMIAIYAVLTEAFYTPLFIRYDTLTLNQ 865

  Fly   769 KSDYAHT----WYLVALFIVLVL-RERHVNYLRKFNYFMRVCYEEAHQQTDEKLRSIKIIMANIL 828
            ...:..|    ..|:|:|::.|. ..:.:.|..:.::..||..:|...:..|.....:.::.|||
Zfish   866 SKSFLGTKETSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMRELREHNENMLRNIL 930

  Fly   829 PTHVAQVYKVR-RPHDQLYYENFSKVAVMFASIENF----------NADTAGLRILHEIICCFDD 882
            |:|||:.:..: |.:::||.:::..|.||||||..|          |.....||:|:|||..||:
Zfish   931 PSHVARHFLEKDRDNEELYSQSYDTVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDE 995

  Fly   883 LLVDYQTRYK-IEKIKVMGWTYMVACGLETDHYTDFSIDIPVKQPEADSEIRRGSSVLTVHFGST 946
            ||  .:.|:: |||||.:|.|||...||.           |.||
Zfish   996 LL--GEERFQDIEKIKTIGSTYMAVSGLS-----------PEKQ--------------------- 1026

  Fly   947 EDDEMSGDNVSQPYAQVQDV--AVLVMTEFALDLLRIMHDIRYNYVFSEYDTFLTGSLKIGISHG 1009
                           |.:|.  .:..:.:||:.|...:.:|. .:.|:.:      .|:||::||
Zfish  1027 ---------------QCEDKWGHLCALADFAIALNESIQEIN-KHSFNNF------QLRIGMAHG 1069

  Fly  1010 SVMAGVVGLSKPHYDIWGHTVNMASRMSSTGLLDNIQVTRHTAKVLRQFNIRCNYRGHTEVKGV- 1073
            ||:|||:|..||.|||||.|||:||||.|||:...||:...|..:|.:......|||...|||:
Zfish  1070 SVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGKIQLPEETYAILNERGFAFEYRGEIYVKGIS 1134

  Fly  1074 ---GKVPTYLVV--VDPD 1086
               ||:.|:.::  |.|:
Zfish  1135 EQEGKIRTHFMIGRVQPN 1152

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	86/197 (44%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	78/152 (51%)
		CYCc	814..1056	CDD:214485	83/255 (33%)
		Nucleotidyl_cyc_III	845..1081	CDD:299850	84/252 (33%)
adcy8	NP_001137224.1	AC_N	<135..374	CDD:292831	47/244 (19%)
		CYCc	340..538	CDD:214485	85/203 (42%)
		Guanylate_cyc	379..563	CDD:278633	88/184 (48%)
		DUF1053	592..685	CDD:283888	12/102 (12%)
		CYCc	919..1123	CDD:214485	83/259 (32%)
		Guanylate_cyc	948..1147	CDD:278633	84/254 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910