Protein Alignment CG12111 and ACAN

DIOPT Version :10

• Sequence 1: NP_572491.1
• Gene: CG12111 / 31796
• FlyBaseID: FBgn0030050
• Length: 188
• Species: Drosophila melanogaster
• Sequence 2: NP_001356197.1
• Gene: ACAN / 176
• HGNCID: 319
• Length: 2568
• Species: Homo sapiens
• Alignment Length: 97
• Identity: 27/97 - (27%)
• Similarity: 33/97 - (34%)
• Gaps: 28/97 - (28%)

  Fly    66 SPPSQPKENPFNSVFRQKRRSTFSGLPAWCQCEPTKPKCPRGPP--GPPGHPGQRGIPGIPGRNG 128
            |||||....|        ..|.....|:...|    ||..|.|.  .||..| |..:...|..:.
Human   658 SPPSQGDPGP--------SLSKLDPRPSQSPC----PKLLRVPTRHSPPESP-QLLVSTEPNSDA 709

  Fly   129 QDNYNTIRAPACP-----PRNQDCIKCPAGPP 155
            .....:|.:|:|.     ||||        ||
Human   710 VQRLQSISSPSCSHSAENPRNQ--------PP 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12111	NP_572491.1	CLECT	55..174	CDD:153057	27/97 (28%)
ACAN	NP_001356197.1	Ig_Aggrecan	33..155	CDD:409481
		Ig strand A	33..36	CDD:409481
		Ig strand A'	39..41	CDD:409481
		Ig strand B	45..53	CDD:409481
		G1-A	48..141
		Ig strand C	72..78	CDD:409481
		Ig strand C'	83..86	CDD:409481
		Ig strand D	104..109	CDD:409481
		Ig strand E	115..121	CDD:409481
		Ig strand F	129..136	CDD:409481
		Ig strand G	146..155	CDD:409481
		G1-B	152..247
		Link_domain_CSPGs_modules_1_3	153..247	CDD:239594
		G1-B'	253..349
		Link_domain_CSPGs_modules_2_4	254..349	CDD:239597
		G2-B	477..571
		Link_domain_CSPGs_modules_1_3	478..572	CDD:239594
		G2-B'	578..673		7/22 (32%)
		Link_domain_CSPGs_modules_2_4	579..674	CDD:239597	7/23 (30%)
		KS	677..849		19/70 (27%)
		PHA03307	716..>975	CDD:223039	9/26 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	734..979		27/97 (28%)
		12 X 6 AA approximate tandem repeats of E-[GVE]-P-[SFY]-[APT]-[TSP]	773..844
		CS-1	852..1612
		35 X 19 AA approximate tandem repeats of E-[IVDG]-[LV]-[EV]-[GTI]-[STA]-[ATV]-[SP]-[GA]-[VIFAD]- [GEDL]-[DE]-[LVI]-[SG]-[GERK]-[LV]-P-S-G	942..1612
		PRK15387	<1433..>1614	CDD:185285
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1499..1526
		TamB	1511..2016	CDD:442155
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1543..1649
		CS-2	1613..2277
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1687..1772
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1784..1827
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1883..1902
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1948..1977
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2048..2204
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2249..2281
		EGF_CA	2283..2313	CDD:238011
		EGF_CA	2316..2352	CDD:238011
		CLECT_CSPGs	2358..2481	CDD:153058
		CCP	2485..2541	CDD:153056
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2548..2568