DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32281 and TRM5

DIOPT Version :9

Sequence 1:	NP_728821.2	Gene:	CG32281 / 317953	FlyBaseID:	FBgn0052281	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_011937.1	Gene:	TRM5 / 856467	SGDID:	S000001112	Length:	499	Species:	Saccharomyces cerevisiae

Alignment Length:	492	Identity:	169/492 - (34%)
Similarity:	242/492 - (49%)	Gaps:	81/492 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 NRLRHYFRNMDVKELQPPSSVRGMQELQREQFRKIVQVPRLRVPESQVQRVMPLVKKF---LLKM 76
            |||....:...|....||.: |.|:||.|..|  |.::|...|...:.:.:....|.|   :|::
Yeast    12 NRLISSCKMSGVFPYNPPVN-RQMRELDRSFF--ITKIPMCAVKFPEPKNISVFSKNFKNCILRV 73

  Fly    77 EHLHPVRAVDQSRE-------------------------ILLHPT--PVKN-WDSLPTEDLQRQK 113
            ..:..|..::.|:.                         :|||.:  .|:: :..||.:.|...|
Yeast    74 PRIPHVVKLNSSKPKDELTSVQNKKLKTADGNNTPVTKGVLLHESIHSVEDAYGKLPEDALAFLK 138

  Fly   114 VNAENFSFADLELRYENWSANEILKSVLPTE--EEGLTSYSRIGHIAHLNLRDHLLPYKQLIGQV 176
            .|:......:..|.|:.|.|.|||::|||.:  ||..|.::..|||||||||....|:..|||||
Yeast   139 ENSAEIVPHEYVLDYDFWKAEEILRAVLPEQFLEEVPTGFTITGHIAHLNLRTEFKPFDSLIGQV 203

  Fly   177 LRDKLPNCRTVVNKASSIDNTYRNFQLELICGDPD-YQVETKENGVPFEFDFSKVYWNPRLSTEH 240
            :.||......||:|.|||...:|.|.:::|.|..| ..||.||:...|:|||||||||.||.|||
Yeast   204 ILDKNNKIECVVDKVSSIATQFRTFPMKVIAGKSDSLVVEQKESNCTFKFDFSKVYWNSRLHTEH 268

  Fly   241 ERIVKM-LKSDDVLYDVFAGVGPFSIPAAKKRCHVLANDLNPESFRWLQHNAKRNKCLPNIKMSN 304
            ||:||. .:...|:.|||||||||::||.||...||||||||||:::|:.|...||....:|..|
Yeast   269 ERLVKQYFQPGQVVCDVFAGVGPFAVPAGKKDVIVLANDLNPESYKYLKENIALNKVAKTVKSFN 333

  Fly   305 KDGRQFI------VEELRED-----------LLKRLCTTD---------------TTTYGIHITM 337
            .||..||      :::..:|           |.||..:..               ..::..|..|
Yeast   334 MDGADFIRQSPQLLQQWIQDEEGGKITIPLPLKKRHRSQQHNDQQPPQPRTKELIIPSHISHYVM 398

  Fly   338 NLPAMAVEFLDAFRGLYSADELAQLPTNVCYPTVHVYSFAK---GEN-TKELVRQLVESNLGASL 398
            |||..|:.||..|||:::|.......| :..|.|||:.|.|   |:. |::.:...|.:.:.|:|
Yeast   399 NLPDSAISFLGNFRGIFAAHTKGATDT-IQMPWVHVHCFEKYPPGDQVTEDELHARVHARIIAAL 462

  Fly   399 ----DENLLQGI--NFVRNVAPNKDMYRVSFKLSLNM 429
                |:..|..:  :.||.|||.|.||..||:|..|:
Yeast   463 KVTADDLPLNAVSLHLVRKVAPTKPMYCASFQLPANV 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32281	NP_728821.2	Met_10	149..353	CDD:280612	100/237 (42%)
CG32281	NP_728821.2	AdoMet_MTases	224..>313	CDD:302624	52/95 (55%)
TRM5	NP_011937.1	Trm5	75..459	CDD:225318	135/384 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341677
Domainoid	1	1.000	160	1.000	Domainoid score	I857
eggNOG	1	0.900	-	-		E1_COG2520
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6096
Inparanoid	1	1.050	209	1.000	Inparanoid score	I814
Isobase	1	0.950	-	0	Normalized mean entropy	S1922
OMA	1	1.010	-	-		QHG54511
OrthoFinder	1	1.000	-	-		FOG0002786
OrthoInspector	1	1.000	-	-		oto99826
orthoMCL	1	0.900	-	-		OOG6_100981
Panther	1	1.100	-	-	LDO	PTHR23245
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1549
SonicParanoid	1	1.000	-	-		X2185
TreeFam	1	0.960	-	-
	16	15.740