DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32281 and C53A5.17

DIOPT Version :9

Sequence 1:	NP_728821.2	Gene:	CG32281 / 317953	FlyBaseID:	FBgn0052281	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_001256592.1	Gene:	C53A5.17 / 13216595	WormBaseID:	WBGene00194707	Length:	474	Species:	Caenorhabditis elegans

Alignment Length:	460	Identity:	163/460 - (35%)
Similarity:	246/460 - (53%)	Gaps:	65/460 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LRHYFRNMDVKELQPPSSVRGMQELQREQFRKIVQVPRLRVPESQV----QRVMPLVKKFLLKME 77
            |:..|.||.:  ||||..||||.:|::|.||..|..|.:.:.....    :||.  ::.:|:. .
Worm     4 LKRLFSNMSI--LQPPEVVRGMTKLEKEAFRMPVDFPVIEIEARDAGIVGRRVR--LEPYLIG-H 63

  Fly    78 HLHPVR-AVDQSRE----ILLHPTPVKNWDSLPTED---------LQRQKVNAENFSFADL--EL 126
            .|.|:: .||..::    ::.||..|:       ||         |:|:..|.:...:..|  :|
Worm    64 KLKPLKNLVDSEKDGKKYLVFHPDKVQ-------EDETRFKILELLKRELGNEKLLDWTTLSKDL 121

  Fly   127 RYENWSANEILKSVLPTEEEGL--TSYSRIGHIAHLNLRDHLLPYKQLIGQVLRDKLPNCRTVVN 189
            .:|||.|..|.|:|||.   |:  :||::.|||.|.|..|.:||::.:|.:||.||:.||:|||.
Worm   122 TFENWDAKSIFKAVLPV---GIDYSSYTQTGHIIHCNFADEILPFRFIIAEVLLDKVNNCKTVVQ 183

  Fly   190 KASSIDNTYRNFQLELICGDPDYQVETKENGVPFEFDFSKVYWNPRLSTEHERIVKMLKSDDVLY 254
            |.:.|.|.|||..|||:.|:.:|..|.||.|:.|:.||||||||.|||.||||:..|..:..::|
Worm   184 KGNIITNVYRNLDLELLAGEDNYVTEVKETGLRFKMDFSKVYWNSRLSHEHERVSGMFNTQSLVY 248

  Fly   255 DVFAGVGPFSIPAAKKR--CHVLANDLNPESFRWLQHNAKRNKCL-PNIKMSNKDGRQFIVEELR 316
            |...|:|||.:||..||  ..|:||||||||.:||:.|...||.. ..|::.|.|.:.||.|.:.
Worm   249 DACCGIGPFVLPATLKRKPKRVVANDLNPESVKWLKVNVGLNKIKEERIEIHNMDAKMFIKENVA 313

  Fly   317 EDLLKRLCTTDTTTYG------------IHITMNLPAMAVEFLDAFRGLYS--ADELAQLPTNVC 367
            :|:::.:  .:.:|.|            :|:.|||||.||.||.||||..|  .||:.::|.:..
Worm   314 DDVVRLM--LEESTAGEFENEVPKPMSEVHVVMNLPAYAVNFLPAFRGALSRFKDEIEKVPLDKR 376

  Fly   368 YP-TVHVYSFAKGENT------KELVRQLVESNLGASLDENLLQGINFVRNVAPNKDMYRVSFKL 425
            |. .|:.|.|||....      ::..|::.:..  ...:.:|:...:.||.|:..|:|:....:|
Worm   377 YKWNVYCYLFAKSHVDVPDSWYEDEARRMCDEK--TKWERSLVVKCHNVRTVSSRKEMFCAQLEL 439

  Fly   426 SLNML 430
            ....|
Worm   440 PYEFL 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32281	NP_728821.2	Met_10	149..353	CDD:280612	98/218 (45%)
CG32281	NP_728821.2	AdoMet_MTases	224..>313	CDD:302624	45/91 (49%)
C53A5.17	NP_001256592.1	Met_10	144..363	CDD:280612	99/220 (45%)
C53A5.17	NP_001256592.1	AdoMet_MTases	268..>311	CDD:302624	19/42 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156679
Domainoid	1	1.000	190	1.000	Domainoid score	I1941
eggNOG	1	0.900	-	-		E1_COG2520
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6096
Inparanoid	1	1.050	245	1.000	Inparanoid score	I2062
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54511
OrthoDB	1	1.010	-	-		D532693at33208
OrthoFinder	1	1.000	-	-		FOG0002786
OrthoInspector	1	1.000	-	-		oto17847
orthoMCL	1	0.900	-	-		OOG6_100981
Panther	1	1.100	-	-	LDO	PTHR23245
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1549
SonicParanoid	1	1.000	-	-		X2185
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800