Protein Alignment Trf4-1 and PAP2

DIOPT Version :10

• Sequence 1: NP_572490.2
• Gene: Trf4-1 / 31795
• FlyBaseID: FBgn0030049
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: NP_014526.1
• Gene: PAP2 / 854034
• SGDID: S000005475
• Length: 584
• Species: Saccharomyces cerevisiae
• Alignment Length: 708
• Identity: 181/708 - (25%)
• Similarity: 287/708 - (40%)
• Gaps: 162/708 - (22%)

  Fly    47 GSTSSSSSSSNSGNNNNNNNNNIINNTITNTTNNTGNNSSAKPYLSRPYSSLNRVLNFRADSLEI 111
            |:.|.::|||..               |.|..|.....|.....:.:|..|::  || ..:.:||
Yeast     2 GAKSVTASSSKK---------------IKNRHNGKVKKSKKIKKVRKPQKSIS--LN-DENEVEI 48

  Fly   112 LQQQQQQQQLNGTTQRNSTNINTTSGGSTSSSADSTTNRDNNSPANSSSTNGPGAGTGTSTGAGG 176
            |..:.:|:    |.:....::          :||.....::.|..:.        |.....|...
Yeast    49 LPSRNEQE----TNKLPKDHV----------TADGILVLEHKSDDDE--------GFDVYDGHFD 91

  Fly   177 TGTNSPATTASSTAATTTGPATSM----SDTSNNPPQSTTTPASRTNSIYYNPSRKKRPENKAGG 237
            ..|:.|:||..|..     |:.::    .|.:||....:.:.:|..........|:|:
Yeast    92 NPTDIPSTTEESKT-----PSLAVHGDEKDLANNDDFISLSASSEDEQAEQEEEREKQ------- 144

  Fly   238 AHYYMNNHMEMIAKYKGEPWRKPDYPYGEGVIGLHE-------------EIEHFYQYVLPTPCEH 289
                   .:| |.|.|.:.....|||:    |..|:             ||:.|..|:.|:..|.
Yeast   145 -------ELE-IKKEKQKEILNTDYPW----ILNHDHSKQKEISDWLTFEIKDFVAYISPSREEI 197

  Fly   290 AIRNEVVKRIEAVVHSIWPQAVVEIFGSFRTGLFLPTSDIDLVVL----GLWEKLPLRTLEFELV 350
            .|||:.:..|...|..:||.|.:.:|||:.|.|:||.||||.||.    |...:..|.:|...|.
Yeast   198 EIRNQTISTIREAVKQLWPDADLHVFGSYSTDLYLPGSDIDCVVTSELGGKESRNNLYSLASHLK 262

  Fly   351 SRGIAEACTVRVLDKASVPIIKLTDRETQVKVDISFNMQSGVQSAELIKKFKRDYPVLEKLVLVL 415
            .:.:  |..|.|:.||.|||||..:..:.:.:|:||...:|:::|:||:::..|.|.|.:|||::
Yeast   263 KKNL--ATEVEVVAKARVPIIKFVEPHSGIHIDVSFERTNGIEAAKLIREWLDDTPGLRELVLIV 325

  Fly   416 KQFLLLRDLNEVFTGGISSYSLILMCISFLQMHPRGIYHD---TANLGVLLLEFFELYGRRFNYM 477
            ||||..|.||.|.|||:..:|:|.:..|||.||||.|.::   ..||||||:|||||||:.|.|.
Yeast   326 KQFLHARRLNNVHTGGLGGFSIICLVFSFLHMHPRIITNEIDPKDNLGVLLIEFFELYGKNFGYD 390

  Fly   478 KIGISIKNG-GRYMPKDELQRDMVDGHRPSLLCIEDPLTPGNDIGRSSYGVFQVQQAFKCAYRVL 541
            .:.:...:| ..|.||..... :.....|..|.|:||....|:|.|.|:.:..:::||..|:.:|
Yeast   391 DVALGSSDGYPVYFPKSTWSA-IQPIKNPFSLAIQDPGDESNNISRGSFNIRDIKKAFAGAFDLL 454

  Fly   542 ALAVSPLNLLGIDPRV-NSILGRIIHITDDVIDYREWIRENFEHLVVVDRISPLPTAAPTAYATA 605
            ......|:......|: .||||.:|.......|:::      |..:|:::
Yeast   455 TNRCFELHSATFKDRLGKSILGNVIKYRGKARDFKD------ERGLVLNK--------------- 498

  Fly   606 NGAPKYVIMPSGAVVQQLYHHPVQVPTAHGHSHAHSHSHGHAHPGAHLCQPYVTGTTVSAVTTTT 670
                        |:::...:|..:....|....|..                   |..|..|.||
Yeast   499 ------------AIIENENYHKKRSRIIHDEDFAED-------------------TVTSTATATT 532

  Fly   671 TMAVVTVGVSAGGVQQQQQQQNATAHTHSQQQTQNQSQSRHRRGST----SSGDDSED 724
            |             ....:..|..|.....::......::...|.|    ||.||.||
Yeast   533 T-------------DDDYEITNPPAKKAKIEEKPESEPAKRNSGETYITVSSEDDDED 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trf4-1	NP_572490.2	TRF4	271..>583	CDD:227585	116/333 (35%)
PAP2	NP_014526.1	TRF4	116..584	CDD:227585	152/549 (28%)