DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trf4-1 and TUT7

DIOPT Version :9

Sequence 1:	NP_001259340.1	Gene:	Trf4-1 / 31795	FlyBaseID:	FBgn0030049	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_011517313.1	Gene:	TUT7 / 79670	HGNCID:	25817	Length:	1551	Species:	Homo sapiens

Alignment Length:	384	Identity:	86/384 - (22%)
Similarity:	136/384 - (35%)	Gaps:	125/384 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 YQYVLPTPCEHAIRNEVVKRIEAVVHSIWPQAVVEIFGSFRTGLFLPTSDID--LVVLGL--WEK 339
            |:...||..|...|..:.:.:|:.:...:|...:.:|||.:.|.....||:|  :.:.||  .|.
Human  1009 YKDFSPTIIEDQAREHIRQNLESFIRQDFPGTKLSLFGSSKNGFGFKQSDLDVCMTINGLETAEG 1073

  Fly   340 LP-LRTLEFELVSRGIAEACTVRVLDK------------ASVPIIKLTDRETQVKVDISFNMQSG 391
            |. :||:| ||          .|||.|            |.|||:|.....:.::||||......
Human  1074 LDCVRTIE-EL----------ARVLRKHSGLRNILPITTAKVPIVKFFHLRSGLEVDISLYNTLA 1127

  Fly   392 VQSAELIKKFKRDYPVLEKLVLVLKQFLLLRDLNEVFTGGISSYSLILMCISFLQMH-------- 448
            :.:..|:..:....|.::.|...:|.|..:.|:.:...|.:|||:..||.:.|||..
Human  1128 LHNTRLLSAYSAIDPRVKYLCYTMKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQQRNPPVIPVL 1192

  Fly   449 ---------PR------GIY----------------HDTANLGVLLLEFFELYGRRFNYMKIGIS 482
                     |.      .||                .:|.::|.|.|.....|...|::.:..||
Human  1193 QEIYKGEKKPEIFVDGWNIYFFDQIDELPTYWSECGKNTESVGQLWLGLLRFYTEEFDFKEHVIS 1257

  Fly   483 IKNGGRYMPKDELQRDMVDGHRPSLL------------CIEDPLTPGNDIGRSSYGVFQ-----V 530
            |:                   |.|||            .||||....:::|.   |:.:     :
Human  1258 IR-------------------RKSLLTTFKKQWTSKYIVIEDPFDLNHNLGA---GLSRKMTNFI 1300

  Fly   531 QQAFKCAYRVLALAVS------PLNL-------------LGIDPRVNSILGRIIHITDD 570
            .:||....||..:.|.      |..:             |..:.|...|.|:|.|...|
Human  1301 MKAFINGRRVFGIPVKGFPKDYPSKMEYFFDPDVLTEGELAPNDRCCRICGKIGHFMKD 1359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trf4-1	NP_001259340.1	NT_PAP_TUTase	291..401	CDD:143392	33/126 (26%)
Trf4-1	NP_001259340.1	PAP_assoc	458..518	CDD:281779	16/71 (23%)
TUT7	XP_011517313.1	NT_PAP_TUTase	315..427	CDD:143392
		PAP_assoc	550..599	CDD:281779
		NT_PAP_TUTase	1021..1138	CDD:143392	33/127 (26%)
		PAP_assoc	1233..1286	CDD:281779	16/71 (23%)
		TUTF7_u4	1371..1450	CDD:293237
		ZnF_C2HC	1452..1468	CDD:197667
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810