DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trf4-1 and Tut1

DIOPT Version :9

Sequence 1:	NP_001259340.1	Gene:	Trf4-1 / 31795	FlyBaseID:	FBgn0030049	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_932110.1	Gene:	Tut1 / 70044	MGIID:	1917294	Length:	869	Species:	Mus musculus

Alignment Length:	701	Identity:	128/701 - (18%)
Similarity:	217/701 - (30%)	Gaps:	240/701 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 AATTTGPATSMSDTSNNPPQST--TTPASRTNSIYYNPSRKKRPENKAGGAHYYMNNHMEMIAKY 252
            |.|...|..|:|.||....:|.  .||:|..         .:.|::..|.........:..::..
Mouse   258 ACTPASPLDSLSPTSVQESESLDFDTPSSLA---------PQTPDSALGSDTVTSPQSLPPVSPL 313

  Fly   253 KGEPWRKPDYPYGEGVIGLHEEIEHFYQYVLPTPCEHAIRNEVVKRIEAVVHSIWPQAVVEIFGS 317
            :.:  ||      ||..|...|:           .|.|.::|   :.||.       ||:|:.||
Mouse   314 QED--RK------EGKQGKELEL-----------AEEASKDE---KEEAA-------AVLELVGS 349

  Fly   318 FRTGLFLPTSDIDLVVLGLWEKLPLRTLEFELVSRGIAEACTVRVLDKASVPIIKLTDRETQVKV 382
            ...|          .|.|::.                     |:.:..|..|::|...|.:.:..
Mouse   350 ILRG----------CVPGVYR---------------------VQTVPSARRPVVKFCHRPSGLHG 383

  Fly   383 DISFNMQSGVQSAELIKKFKRDYPVLEKLVLVLKQFLLLRDLNEVFTGG--ISSYSLILMCISFL 445
            |:|.:.:..:.::..:.........:..||..|:.:   ...|.:..||  :::|:|.|:.|.||
Mouse   384 DVSLSNRLALYNSRFLNLCSEMDGRVRPLVYTLRCW---AQHNGLSGGGPLLNNYALTLLVIYFL 445

  Fly   446 QMHPRGIYHDTAN-----------------------------------LGVLLLEFF------EL 469
            |.....:....|.                                   |..||.:||      :|
Mouse   446 QTRDPPVLPTVAQLTQRAGEGEQVEVDGWDCSFPKDASRLEPSTNVEPLSSLLAQFFSCVSCLDL 510

  Fly   470 YGRRFNYMKIGISIKNGGRYMPKDELQRDMVDGHRPSLLCIEDPLTPGNDIGRSSYGVFQVQQAF 534
            .|..       :|::.|...|..:.|..|:.:|.|...:.::||                    |
Mouse   511 SGSL-------LSLREGRPLMVAEGLPSDLWEGLRLGPMNLQDP--------------------F 548

  Fly   535 KCAYRVLALAVSPLNLLG-IDPRVNSILG------RIIHITDDVIDYREWIRENFEHLVVVDRIS 592
            ..::.|.|      |:.| :..|:.|..|      |.:.........|:|              .
Mouse   549 DLSHNVAA------NVTGRVAKRLQSCCGAAASYCRSLQYQQRSSRGRDW--------------G 593

  Fly   593 PLPTAAPTAYATANGAPKYVIMPSGAVVQQLYHHPVQVPTAHGHSHAHSHSHGHAHPGAHLCQPY 657
            .||...|::.::...| |.:.:|| |...|:....|.|.......|....:......||.:...
Mouse   594 LLPLLQPSSPSSLLSA-KLIPLPS-APFPQVIMALVDVLREALGCHIEQGTKRRRSEGARIKDS- 655

  Fly   658 VTGTTVSAVTTTTTMAVVTVGVSAGGVQQQQQQQNATAHTHSQQQTQNQSQSRHRRGSTSSGDDS 722
                                  ..|||.::|:   ......|.::.:.:.|.       .:||.|
Mouse   656 ----------------------PLGGVNKRQR---LGGQEKSFEEGKEEPQG-------CAGDHS 688

  Fly   723 EDSKDGDVVETTSSAQEVV---------DIALSTPNGLANMSMPMPVHAVGMPASNSWSGNGNGN 778
            |:..:..|:|...:.|:..         ::.|.|.|.|...       |...|.....:|.|
Mouse   689 ENEVEEMVIEVRETPQDWALLHSGPPEEELPLMTANCLDKA-------AEHNPMKPEVAGEG--- 743

  Fly   779 GNSSSSTGSSPEIAHIAAQEMDPELEDQ-----------QQQQQHQETSGG 818
              |...||.  |.:|.::......|..|           .|||..:|..||
Mouse   744 --SQGETGK--EASHPSSVSWRCALWHQVWQGRRRARRRLQQQTKEEGRGG 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trf4-1	NP_001259340.1	NT_PAP_TUTase	291..401	CDD:143392	18/109 (17%)
Trf4-1	NP_001259340.1	PAP_assoc	458..518	CDD:281779	16/100 (16%)
Tut1	NP_932110.1	ZnF_U1	14..47	CDD:197732
		RRM_TUT1	54..127	CDD:240725
		RRM	<56..>140	CDD:223796
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..144
		NT_PAP_TUTase	179..403	CDD:143392	39/213 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..247
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..335		20/103 (19%)
		KA1, binds the bulging loops of U6 snRNA but is dispensable for terminal uridylyltransferase activity. /evidence=ECO:0000250\|UniProtKB:Q9H6E5	601..869		45/239 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	640..689		10/81 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	735..757		7/28 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	775..796		6/16 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	803..822
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810