DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trf4-1 and TUT1

DIOPT Version :9

Sequence 1:	NP_001259340.1	Gene:	Trf4-1 / 31795	FlyBaseID:	FBgn0030049	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_073741.3	Gene:	TUT1 / 64852	HGNCID:	26184	Length:	874	Species:	Homo sapiens

Alignment Length:	751	Identity:	140/751 - (18%)
Similarity:	227/751 - (30%)	Gaps:	281/751 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 SPATTASSTAATTTGPATSMSDTSNNPPQSTTTPASRTNS---IYYNPSRKKRPENKAGGAHYYM 242
            :|.:.:..:|..:.....:::.|..:||.| ..|||..:|   .:..||....|:......
Human   235 APESPSLDSALASPLDPQALACTPASPPDS-QPPASPQDSEALDFETPSSSLAPQTPDSAL---- 294

  Fly   243 NNHMEMIAKYKGEPWRKPDYPY----GEGVIGLHEEIEHFYQYVLPTPCEHAIRNEVVKRIEAVV 303
              ..|.:|..:..|   |..|.    .||.:|...|:..       ||.|        ::.|..
Human   295 --ASETLASPQSLP---PASPLLEDREEGDLGKASELAE-------TPKE--------EKAEGA- 338

  Fly   304 HSIWPQAVVEIFGSFRTGLFLPTSDIDLVVLGLWEKLPLRTLEFELVSRGIAEACTVRVLDKASV 368
                  |::|:.||...|          .|.|::.                     |:.:..|..
Human   339 ------AMLELVGSILRG----------CVPGVYR---------------------VQTVPSARR 366

  Fly   369 PIIKLTDRETQVKVDISFNMQSGVQSAELIKKFKRDYPVLEKLVLVLKQFLLLRDLNEVFTGG-- 431
            |::|...|.:.:..|:|.:.:..:.::..:.........:..||..|:.:...|.|    :|.
Human   367 PVVKFCHRPSGLHGDVSLSNRLALHNSRFLSLCSELDGRVRPLVYTLRCWAQGRGL----SGSGP 427

  Fly   432 -ISSYSLILMCISFLQMH------------------------------PRGIYHDTANLGV---- 461
             :|:|:|.|:.|.|||..                              ||.......::.|
Human   428 LLSNYALTLLVIYFLQTRDPPVLPTVSQLTQKAGEGEQVEVDGWDCSFPRDASRLEPSINVEPLS 492

  Fly   462 -LLLEFF------ELYGRRFNYMKIGISIKNGGRYMPKDELQRDMVDGHRPSLLCIEDPLTPGND 519
             ||.:||      :|.|..       :|::.|........|..::.:|.|...|.::||
Human   493 SLLAQFFSCVSCWDLRGSL-------LSLREGQALPVAGGLPSNLWEGLRLGPLNLQDP------ 544

  Fly   520 IGRSSYGVFQVQQAFKCAYRVLALAVSPLNLLGIDPRVNSILGRIIHITDDVIDY---------- 574
                          |..::.|.|...|            .:.||:.:......:|
Human   545 --------------FDLSHNVAANVTS------------RVAGRLQNCCRAAANYCRSLQYQRRS 583

  Fly   575 ---REWIRENFEHLVVVDRISPLPTAAPTAYATANGAPKYVIMPSGAVVQQLYHHPVQVPTAHGH 636
               |:|              ..||...|::             ||..    |...|:.:|.|
Human   584 SRGRDW--------------GLLPLLQPSS-------------PSSL----LSATPIPLPLA--- 614

  Fly   637 SHAHSHSHGHAHPGAHLCQPYVTGTTVSAVTTTTTMAVVTVGVSAGGVQQQQQQQNATAHTHSQQ 701
                               |:          |..|.|:|.|...|.|...:|    ||..|.|:.
Human   615 -------------------PF----------TQLTAALVQVFREALGCHIEQ----ATKRTRSEG 646

  Fly   702 QTQNQSQSRHRRGSTS----------------------SGDDSEDSKDGDVVETTSSAQEVV--- 741
            ....:|.    :|.||                      :||..||..:..|:|.....|:..
Human   647 GGTGESS----QGGTSKRLKVDGQKNCCEEGKEEQQGCAGDGGEDRVEEMVIEVGEMVQDWAMQS 707

  Fly   742 -----DIALSTPNGLANMSMPMPVHAV-------GMPASNSWSGNGNGNGNSSSSTGS-SPEIAH 793
                 |:.|:|....|......|.||.       |..|:..||....|.|.|..|:.| ...:.|
Human   708 PGQPGDLPLTTGKHGAPGEEGQPSHAALAERGPKGHEAAQEWSQGEAGKGASLPSSASWRCALWH 772

  Fly   794 IAAQEMDPELEDQQQQQQHQETSGGNGFIRPGDVGT 829
            ...|  ......::.|||.:|.:||....|.|.:.|
Human   773 RVWQ--GRRRARRRLQQQTKEGAGGGAGTRAGWLAT 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trf4-1	NP_001259340.1	NT_PAP_TUTase	291..401	CDD:143392	15/109 (14%)
Trf4-1	NP_001259340.1	PAP_assoc	458..518	CDD:281779	15/70 (21%)
TUT1	NP_073741.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..146
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..334		23/106 (22%)
		KA1, binds the bulging loops of U6 snRNA but is dispensable for terminal uridylyltransferase activity. /evidence=ECO:0000269\|PubMed:28589955	598..874		57/268 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	638..662		8/27 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	705..761		14/55 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910