Protein Alignment Trf4-1 and TENT4B

DIOPT Version :9

• Sequence 1: NP_001259340.1
• Gene: Trf4-1 / 31795
• FlyBaseID: FBgn0030049
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: NP_001352253.1
• Gene: TENT4B / 64282
• HGNCID: 30758
• Length: 713
• Species: Homo sapiens
• Alignment Length: 924
• Identity: 322/924 - (34%)
• Similarity: 430/924 - (46%)
• Gaps: 230/924 - (24%)

  Fly     1 MDPFVGWFQKEQEGPSLCTWLKIWETNAQEMGALLNQQLQQATTINGSTSSSSSSSNSGNNNNNN 65
            |||.:.|||.||.|||...|::||||.........|.....:...:|...||||||.:...:.
Human     1 MDPRIAWFQPEQLGPSNSLWMQIWETTQGLRNLYFNHHCHSSGGASGGGGSSSSSSTATGGSG-- 63

  Fly    66 NNNIINNTITNTTNNTGNNSSA-KPYLSRPYSSLNRVLNFRADSLEILQQQQQQQQLNGTTQRNS 129
                      ::|.:.|..:|| .|..:..|.|..|:|...|...|               ||:.
Human    64 ----------SSTGSPGGAASAPAPAPAGMYRSGERLLGSHALPAE---------------QRDF 103

  Fly   130 TNINTTSGGSTSSSADSTTNRDNNSPANSSSTNGPGAGTGTSTGAGGTGTNSPATTAS---STAA 191
            ..:             .|||.:||.       :.|||   .:..||.:.::.|:.::|   |.|.
Human   104 LPL-------------ETTNNNNNH-------HQPGA---WARRAGSSASSPPSASSSPHPSAAV 145

  Fly   192 TTTGPATSMSDTSNNPPQSTTTPASRTNSIYYNPSRKKRPENKAGGAHYYMNNHMEMIAKYKGEP 256
            ....||.|.|.:||...:.........|.....||..:    .|||.......     ..|.|.|
Human   146 PAADPADSASGSSNKRKRDNKASTYGLNYSLLQPSGGR----AAGGGRADGGG-----VVYSGTP 201

  Fly   257 WRKPDYPYGEGVIGLHEEIEHFYQYVLPTPCEHAIRNEVVKRIEAVVHSIWPQAVVEIFGSFRTG 321
            |::.:  |.:||:||||||..||:|:.|.|.|..:|.|||.|||:|:..:||.|.|:|||||:||
Human   202 WKRRN--YNQGVVGLHEEISDFYEYMSPRPEEEKMRMEVVNRIESVIKELWPSADVQIFGSFKTG 264

  Fly   322 LFLPTSDIDLVVLGLWEKLPLRTLEFELVSRGIAEACTVRVLDKASVPIIKLTDRETQVKVDISF 386
            |:||||||||||.|.||.|||.|||..|....:|:..:|:|||||:||||||||..|:|||||||
Human   265 LYLPTSDIDLVVFGKWENLPLWTLEEALRKHKVADEDSVKVLDKATVPIIKLTDSFTEVKVDISF 329

  Fly   387 NMQSGVQSAELIKKFKRDYPVLEKLVLVLKQFLLLRDLNEVFTGGISSYSLILMCISFLQMHPRG 451
            |:|:||::|:|||.|.:.||||..||||||||||.|||||||||||.||||.||.:||||:|||
Human   330 NVQNGVRAADLIKDFTKKYPVLPYLVLVLKQFLLQRDLNEVFTGGIGSYSLFLMAVSFLQLHPR- 393

  Fly   452 IYHD----TANLGVLLLEFFELYGRRFNYMKIGISIKNGGRYMPKDELQRDMVDGHRPSLLCIED 512
              .|    ..|.||||:||||||||.|||:|.||.||:||.|:.|||:|::|:||:|||:|.|||
Human   394 --EDACIPNTNYGVLLIEFFELYGRHFNYLKTGIRIKDGGSYVAKDEVQKNMLDGYRPSMLYIED 456

  Fly   513 PLTPGNDIGRSSYGVFQVQQAFKCAYRVLALAVSPLNLLGIDPRVNSILGRIIHITDDVIDYREW 577
            ||.||||:||||||..||:|||..||.||:.||||:.....:....|||||||.:||:|..||:|
Human   457 PLQPGNDVGRSSYGAMQVKQAFDYAYVVLSHAVSPIAKYYPNNETESILGRIIRVTDEVATYRDW 521

  Fly   578 IRENFEHLVVVDRISPLPTAAPTAYATANGAPKYVIMPSGAVVQQLYHHPVQVPTAHGHSHAHSH 642
            |.:.:                                       .|.:.|
Human   522 ISKQW---------------------------------------GLKNRP--------------- 532

  Fly   643 SHGHAHPGAHLCQPYVTGTTVSAVTTTTTMAVVTVGVSAGGVQQQQQQQNATAHTHSQQQTQNQS 707
                        :|...|..|:.:..|..:......:|        ::..|.....|:   .::|
Human   533 ------------EPSCNGNGVTLIVDTQQLDKCNNNLS--------EENEALGKCRSK---TSES 574

  Fly   708 QSRHRRGSTSSGDDSEDSKDGDVVETTSSAQEVVDIALSTPNGLANMSMPMPVHAVGMPASNSWS 772
            .|:|...| |||..|..|      .|.||:.:|...|  ||       ...|...:..|::
Human   575 LSKHSSNS-SSGPVSSSS------ATQSSSSDVDSDA--TP-------CKTPKQLLCRPST---- 619

  Fly   773 GNGNGNGNSSSSTGSSPEIAHIAAQEMDPELEDQQQQQQHQETSGGNGFIRPGDVGTGSNRGGGD 837
              ||..|:...|..||..:.             :.|..|...||
Human   620 --GNRVGSQDVSLESSQAVG-------------KMQSTQTTNTS--------------------- 648

  Fly   838 GSGGRNYNQRNNHNSSGYYHQQYYVPPPMQQQLSKSNSSSNYHQQHHHSHSHGNHSHRQQHH--H 900
                 |...::.|.|:..:.                :||..:  |.....|||:....:||.  .
Human   649 -----NSTNKSQHGSARLFR----------------SSSKGF--QGTTQTSHGSLMTNKQHQGKS 690

  Fly   901 QQQHHHQQRPQHLR 914
            ..|::|.::.:|.|
Human   691 NNQYYHGKKRKHKR 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trf4-1	NP_001259340.1	NT_PAP_TUTase	291..401	CDD:143392	71/109 (65%)
		PAP_assoc	458..518	CDD:281779	41/59 (69%)
TENT4B	NP_001352253.1	TRF4	214..>486	CDD:227585	180/274 (66%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140747
Domainoid	1	1.000	136	1.000	Domainoid score	I4926
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1016712at2759
OrthoFinder	1	1.000	-	-		FOG0002099
OrthoInspector	1	1.000	-	-		otm40779
orthoMCL	1	0.900	-	-		OOG6_101092
Panther	1	1.100	-	-	O	PTHR23092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2219
SonicParanoid	1	1.000	-	-		X1551
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.740