DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trf4-1 and tut1

DIOPT Version :9

Sequence 1:	NP_001259340.1	Gene:	Trf4-1 / 31795	FlyBaseID:	FBgn0030049	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001025359.1	Gene:	tut1 / 564388	ZFINID:	ZDB-GENE-050706-68	Length:	797	Species:	Danio rerio

Alignment Length:	680	Identity:	127/680 - (18%)
Similarity:	226/680 - (33%)	Gaps:	216/680 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 IGLHEEIEHFYQYVLPTPCEHAIRNEVVKRIEAVVHSIWPQAVVEIFGSFRTGLFLPTSDIDLVV 333
            :.::|:|:...:.:.....|..:|:.:|:.::.|....:|...:..|||......|.:.|:||.:
Zfish   157 MSVNEQIQKVVESLELKDNEKKVRDLLVQLLQEVFTEFFPDCQIVPFGSSVNTFGLHSCDLDLFL 221

  Fly   334 -----------------------------------LGLWEKLPLRTLEFELVSRGIAEACT---- 359
                                               :.|....|...||...|   |...|.
Zfish   222 DLENTKVFQARAKSSEQTGENQSEDCRSEDSILSDIDLSTASPAEILELVAV---ILRKCVPGVH 283

  Fly   360 -VRVLDKASVPIIKLTDRETQVKVDISFNMQSGVQSAELIKKFKRDYPVLEKLVLVLKQFLLLRD 423
             |:.|..|.:|::|.:.:|..::.||:.|.:..|::.:.::........|..||..::.:...:.
Zfish   284 KVQALSTARLPVVKFSHKELNLQGDITINNRLAVRNTKFLQLCSGIDSRLRPLVYTIRLWAKQKQ 348

  Fly   424 LNEVFTGG---ISSYSLILMCISFLQMHPRGIY-------------------------------- 453
            |....:|.   :::|:|.|:.|.|||.....:.
Zfish   349 LAGNLSGPGPLLNNYALTLLVIFFLQNRDPPVLPSVNQLKNMACEEEECAIEEWDCTFPSQPFSV 413

  Fly   454 ---HDTANLGVLLLEFFELYGRRFNYMKIGISIKNGGRYMPKDELQRDMVDGHRPSLLCIEDPLT 515
               .:|.:|..||..||..|. :|::....:|:::|......|.|:.||      ..|...|..:
Zfish   414 PPSKNTEDLCTLLFGFFTFYS-KFDFPASVVSLRDGHVLPITDFLKSDM------EALKTADASS 471

  Fly   516 PGNDIGRSSYGVFQVQQAFKCAYRVLALAVSPLNLLGIDP-RVN-SILGRIIHITDDVIDYREWI 578
            |...  |||                 |..:.|:|:|  || .:| ::.|.:          .|..
Zfish   472 PKPK--RSS-----------------APRLGPMNVL--DPFELNHNVAGNL----------NERT 505

  Fly   579 RENFE----------HLVVVDRISP-------LPTAAPTAYATANGAPK-----YVIMPSGAVVQ 621
            ::||:          ..:...|.|.       :...||.:.|.|:..|:     .|.:|
Zfish   506 QKNFKRECCEAEKYCRSLQYQRKSAKGKSWGLVRLFAPQSEAAASSQPRAEKVLEVSVP------ 564

  Fly   622 QLYHHPVQVPTAHGHSHAHSHSHGHAHPG---AHLCQPYVTGTTVSAVTTTTTMAVVTVGVSAGG 683
               ..|..:|.:   ..|...|.|....|   |.:|         |||..
Zfish   565 ---FKPASLPES---LRAQLASAGKDFRGLWFAEVC---------SAVQK--------------- 599

  Fly   684 VQQQQQQQNATAHTHSQQQTQNQSQSRHRRGSTSSGDDSEDSKDGDV-------VE-------TT 734
            |..:..|.:.|..|.|..:| ::|.|.....:..|.:|:.....|:.       ||       .|
Zfish   600 VFNEILQCSPTEETQSLDKT-DKSGSEMEVNNNRSLEDTNIQVKGEAGKKRPLSVEEGPSTFTIT 663

  Fly   735 SSAQEVVDIALSTPNGLANMSMPMPVHAVGMPASNSWSGNGNGNGN--SSSSTGSSPEIAHIAAQ 797
            .:.::.:|:.|..|.         |:|......|..|:|......:  .:|...|.||...:..:
Zfish   664 QAKRQRLDVDLEHPE---------PLHWTWTQRSRVWAGRRKVRRDLLKTSDEASKPEGGCVDME 719

  Fly   798 --------EMDPELEDQQQQQQHQETSGGN 819
                    |.:.:|.|..:.:...|..|||
Zfish   720 SRVTQSIVEKEEKLHDALEFKVDAEVVGGN 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trf4-1	NP_001259340.1	NT_PAP_TUTase	291..401	CDD:143392	28/149 (19%)
Trf4-1	NP_001259340.1	PAP_assoc	458..518	CDD:281779	16/59 (27%)
tut1	NP_001025359.1	ZnF_U1	11..>38	CDD:197732
		C2H2 Zn finger	16..38	CDD:275371
		RRM	<47..>134	CDD:223796
		RRM_TUT1	52..125	CDD:240725
		NT_PAP_TUTase	179..327	CDD:143392	28/150 (19%)
		PAP_assoc	421..495	CDD:281779	25/101 (25%)
		KA1, binds the bulging loops of U6 snRNA but is dispensable for terminal uridylyltransferase activity. /evidence=ECO:0000250\|UniProtKB:Q9H6E5	544..787		49/252 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..659		10/48 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810