DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trf4-1 and tent4a

DIOPT Version :9

Sequence 1:	NP_001259340.1	Gene:	Trf4-1 / 31795	FlyBaseID:	FBgn0030049	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_009292550.1	Gene:	tent4a / 557829	ZFINID:	ZDB-GENE-041021-1	Length:	763	Species:	Danio rerio

Alignment Length:	889	Identity:	311/889 - (34%)
Similarity:	414/889 - (46%)	Gaps:	204/889 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDPFVGWFQKEQEGPSLCTWLKIWETNAQEMGALLNQQLQQATTINGSTSSSSSSSNSG---NNN 62
            |||.|.|.|.||:||:...|:::|||                        |..:.:|:|   |::
Zfish     1 MDPRVAWIQPEQKGPANALWMRVWET------------------------SQVNRTNTGQHQNHH 41

  Fly    63 NNNNNNIINN-------TITNTTNNT---GNNSSAKPYLSRPYSSLNRVLNFRADSLEILQQQQQ 117
            ::::|..:|:       |:.:..||:   .||.:|.|      .|.:.||
Zfish    42 HHHHNFCVNSPAFDVYKTVASNANNSTNIKNNGTAIP------GSGSAVL--------------- 85

  Fly   118 QQQLNGTTQRNSTNINTTSGGSTSSSADSTTNRDNNSPANSSSTNGPGAGTGTSTGAGGTGTNSP 182
              .|||.......:..|  |||...||.|.|.....||               :..||......|
Zfish    86 --ALNGNAVDGEMSQKT--GGSVVDSASSCTRIRTTSP---------------NVIAGNMNKGQP 131

  Fly   183 ATTASSTAATTTGPATSMSDTSNNPPQ------------------STTTPASRTNSIYYNPSRKK 229
            ..|.:.:.....       :..::||.                  |..|.....:..:::|.|:|
Zfish   132 FFTLNESVLNNV-------NHHHHPPHPHLRHFHQEQQSCMKRHPSYPTAIHNHHHHHHHPGRRK 189

  Fly   230 RPENKAG--GAHYYMNNHMEMIAKYKGEPW--RKPDYPYGEGVIGLHEEIEHFYQYVLPTPCEHA 290
             .:|||.  |.:|.::|......:..|.||  ||    |..||.||||||..||.::.|.|.|..
Zfish   190 -SDNKASTYGINYLLSNWTNGNYESSGTPWKTRK----YSPGVDGLHEEIMDFYNFMSPRPEEAT 249

  Fly   291 IRNEVVKRIEAVVHSIWPQAVVEIFGSFRTGLFLPT-SDIDLVVLGLWEKLPLRTLEFELVSRGI 354
            :|.|||.|||:|:..:||.|.|:|||||.||||||| |||||||.|.|||.||:.||..|....:
Zfish   250 MRQEVVDRIESVIKELWPTADVQIFGSFSTGLFLPTSSDIDLVVFGKWEKPPLQQLEQALRKHSV 314

  Fly   355 AEACTVRVLDKASVPIIKLTDRETQVKVDISFNMQSGVQSAELIKKFKRDYPVLEKLVLVLKQFL 419
            ||..:::|||||:||||||||:||:||||||||:::|:::|..||::.:.|.||..|:.||||||
Zfish   315 AEPYSIKVLDKATVPIIKLTDQETEVKVDISFNVETGIKAASFIKEYVKKYTVLPYLIFVLKQFL 379

  Fly   420 LLRDLNEVFTGGISSYSLILMCISFLQMHPR-GIYHDTANLGVLLLEFFELYGRRFNYMKIGISI 483
            |.|||||||||||||||||||.|||||:||| ...:...|||:||:||||||||.|||:|.||.|
Zfish   380 LQRDLNEVFTGGISSYSLILMVISFLQLHPRIDTRNPNMNLGILLIEFFELYGRHFNYLKTGIRI 444

  Fly   484 KNGGRYMPKDELQRDMVDGHRPSLLCIEDPLTPGNDIGRSSYGVFQVQQAFKCAYRVLALAVSPL 548
            ||||.||.|:::.:.|.:|:|||:|||||||.||||:||||||..||::||..||.:|:.|||||
Zfish   445 KNGGAYMAKEDIMKAMSNGYRPSMLCIEDPLLPGNDVGRSSYGAMQVKEAFDYAYIILSHAVSPL 509

  Fly   549 NLLGIDPRVNSILGRIIHITDDVIDYREWIRENFEHLVVVDRISPLPTAAPTAYATANGAPKYVI 613
            .....:...:|.|||||.:|.:||||||||                                  |
Zfish   510 ARSYPNKDSDSTLGRIIKVTQEVIDYREWI----------------------------------I 540

  Fly   614 MPSGAVVQQLYHHPVQVPTAHGHSHAHSHSHGHAHPGAHLCQPYVTGTTVSAVTTTTTMAVVTVG 678
            ...|.      .|..::....|.||...                     |..|.|.:.:.|
Zfish   541 KKWGG------RHNSRIERNPGSSHKEH---------------------VDQVETGSLLGV---- 574

  Fly   679 VSAGGVQQQQQQQNATAHTHSQQQTQNQSQSRHRRGSTSSGDDSEDSKDGDVVETTSSAQEVVDI 743
                ||::|||:.:.:.|:.....:.:..|......|.||...|:...|    .|...|..|...
Zfish   575 ----GVEEQQQRDSVSPHSADSPMSLSSPQQHSSASSASSLSGSDIDSD----STPYVAPPVAPF 631

  Fly   744 ALS--TPNGL---ANMSMPMPVHAVGMPASNSWSGNGNGN-------GNSSSSTGSSPEIAHIAA 796
            .|.  .|..|   ..|.......|:|||.......:..||       |.........|...|:..
Zfish   632 PLQILAPGPLPPALQMGKASIAAALGMPPVTQARVSIPGNLSLHTLPGRQVCMADGPPSYLHMPP 696

  Fly   797 QEMDPELEDQQQQQQHQETSGG----NGFIRPGDVGTG--SNRG 834
            ..:.|..........|...:|.    .||..|..|.:.  ||||
Zfish   697 PAVPPAPPSPLPSPLHHPKAGPKFPLKGFHNPAVVHSPVLSNRG 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trf4-1	NP_001259340.1	NT_PAP_TUTase	291..401	CDD:143392	69/110 (63%)
Trf4-1	NP_001259340.1	PAP_assoc	458..518	CDD:281779	40/59 (68%)
tent4a	XP_009292550.1	NT_PAP_TUTase	250..362	CDD:143392	69/111 (62%)
tent4a	XP_009292550.1	PAP_assoc	419..479	CDD:281779	40/59 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5213
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1016712at2759
OrthoFinder	1	1.000	-	-		FOG0002099
OrthoInspector	1	1.000	-	-		otm26490
orthoMCL	1	0.900	-	-		OOG6_101092
Panther	1	1.100	-	-	LDO	PTHR23092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1551
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.920