DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trf4-1 and Tent4b

DIOPT Version :9

Sequence 1:	NP_001259340.1	Gene:	Trf4-1 / 31795	FlyBaseID:	FBgn0030049	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_006255323.1	Gene:	Tent4b / 307745	RGDID:	1309587	Length:	700	Species:	Rattus norvegicus

Alignment Length:	932	Identity:	309/932 - (33%)
Similarity:	418/932 - (44%)	Gaps:	260/932 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDPFVGWFQKEQEGPSLCTWLKIWETNAQEMGALLNQQLQQATTINGSTSSSSSSSNSGNNNNNN 65
            |||.:.|||.||.|||...|::||||.........|....       |:.:||:|..||
  Rat     1 MDPRIAWFQPEQLGPSNSLWMQIWETTQGLRNLYFNHHCH-------SSGASSASGGSG------ 52

  Fly    66 NNNIINNTITNTTNNTGNNSSAKPYLSRPYSSLNRVLNFRADSLEILQQQQQQQQLNGTTQRNST 130
                         :..|:.....|..:..:.|..|.|.    .|.:..:|:....|
  Rat    53 -------------SGPGSPGGTAPAPAGMFRSGERPLG----GLAVPAEQRDFLPL--------- 91

  Fly   131 NINTTSGGSTSSSADSTTNRDNNSPANSSSTNGPGAGTGTSTGAGGTGTNSPATTASSTAATTTG 195
                           .|||.:||.                         :.||..|...||   |
  Rat    92 ---------------ETTNNNNNH-------------------------HQPAAWARRAAA---G 113

  Fly   196 PATS-MSDTSNNPPQSTTTPASRTNSIYYNPSRKKRPENKAG--GAHYYMNNHMEMIAK------ 251
            |:.| :....::|..:...|||.:.......|.|::.:|||.  |.:|.:.......|.
  Rat   114 PSASPVPSAPSSPRPAAPLPASESADPASGSSNKRKRDNKASTYGLNYSLLQPSGGRAAGGGRAD 178

  Fly   252 -----YKGEPWRKPDYPYGEGVIGLHEEIEHFYQYVLPTPCEHAIRNEVVKRIEAVVHSIWPQAV 311
                 |.|.||::.:  |.:||:||||||..||:|:.|.|.|..:|.|||.|||:|:..:||.|.
  Rat   179 GGGGVYSGTPWKRRN--YNQGVVGLHEEISDFYEYMSPRPEEEKMRMEVVSRIESVIKELWPSAD 241

  Fly   312 VEIFGSFRTGLFLPTSDIDLVVLGLWEKLPLRTLEFELVSRGIAEACTVRVLDKASVPIIKLTDR 376
            |:|||||:|||:||||||||||.|.||.|||.|||..|....:|:..:|:|||||:||||||||.
  Rat   242 VQIFGSFKTGLYLPTSDIDLVVFGKWENLPLWTLEEALRKHKVADEDSVKVLDKATVPIIKLTDS 306

  Fly   377 ETQVKVDISFNMQSGVQSAELIKKFKRDYPVLEKLVLVLKQFLLLRDLNEVFTGGISSYSLILMC 441
            .|:||||||||:|:||::|:|||.|.:.||||..||||||||||.|||||||||||.||||.||.
  Rat   307 FTEVKVDISFNVQNGVRAADLIKDFTKKYPVLPYLVLVLKQFLLQRDLNEVFTGGIGSYSLFLMA 371

  Fly   442 ISFLQMHPRGIYHD----TANLGVLLLEFFELYGRRFNYMKIGISIKNGGRYMPKDELQRDMVDG 502
            :||||:|||   .|    ..|.||||:||||||||.|||:|.||.||:||.|:.|||:|::|:||
  Rat   372 VSFLQLHPR---EDACIPNTNYGVLLIEFFELYGRHFNYLKTGIRIKDGGSYVAKDEVQKNMLDG 433

  Fly   503 HRPSLLCIEDPLTPGNDIGRSSYGVFQVQQAFKCAYRVLALAVSPLNLLGIDPRVNSILGRIIHI 567
            :|||:|.|||||.||||:||||||..||:|||..||.||:.||||:.....:....|||||||.:
  Rat   434 YRPSMLYIEDPLQPGNDVGRSSYGAMQVKQAFDYAYVVLSHAVSPIAKCYPNNETESILGRIIRV 498

  Fly   568 TDDVIDYREWIRENFEHLVVVDRISPLPTAAPTAYATANGAPKYVIMPSGAVVQQLYHHPVQVPT 632
            ||:|..||:||.:.:                                       .|.:.|
  Rat   499 TDEVTTYRDWISKQW---------------------------------------GLQNRP----- 519

  Fly   633 AHGHSHAHSHSHGHAHPGAHLCQPYVTGTTVSAVTTTTTMAVVTVGVSAGGVQQQQQQQNATAHT 697
                                  :|...|..|:.:..|..:......:|        ::..|....
  Rat   520 ----------------------EPSCNGNGVTLIVETQQLDKCNNNLS--------EENEAPGKC 554

  Fly   698 HSQQQTQNQSQSRHRRGSTSSGDDSEDSKDGDVVETTSSAQEVVDIALSTPNGLANMSMPMPVHA 762
            .|:   .::|.|:|...| |||..|..|      .|.||:.:|...|  ||       ...|...
  Rat   555 RSK---ASESLSKHSSNS-SSGPVSSSS------ATQSSSSDVDSDA--TP-------CKTPKQV 600

  Fly   763 VGMPASNSWSGNGNGNGNSSSSTGSSPEIAHIAAQEMDPELEDQQQQQQHQETSGGNGFIRPGDV 827
            :..|                      |.::.:.:|::..|:.....:.|..:|
  Rat   601 LCRP----------------------PTVSRVGSQDVSLEVSQAVGKMQSTQT------------ 631

  Fly   828 GTGSNRGGGDGSGGRNYNQRNNHNSSGYYHQQYYVPPPMQQQLSKSNSSSNYHQQHH----HSHS 888
                       :...|...::.|.|:..:.             |.|.......|..|    .|..
  Rat   632 -----------TNTANSTNKSQHGSARLFR-------------SSSKGFQGTAQTSHGALMTSKQ 672

  Fly   889 HGNHSHRQQHHHQQQHHHQQRP 910
            |...|:.|.:|.:::.|.:..|
  Rat   673 HPGKSNTQCYHGKKRRHKRDAP 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trf4-1	NP_001259340.1	NT_PAP_TUTase	291..401	CDD:143392	71/109 (65%)
Trf4-1	NP_001259340.1	PAP_assoc	458..518	CDD:281779	41/59 (69%)
Tent4b	XP_006255323.1	NT_PAP_TUTase	221..331	CDD:143392	71/109 (65%)
Tent4b	XP_006255323.1	PAP_assoc	389..449	CDD:281779	41/59 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334432
Domainoid	1	1.000	137	1.000	Domainoid score	I4762
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1016712at2759
OrthoFinder	1	1.000	-	-		FOG0002099
OrthoInspector	1	1.000	-	-		otm44917
orthoMCL	1	0.900	-	-		OOG6_101092
Panther	1	1.100	-	-	O	PTHR23092
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1551
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.750