DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trf4-1 and cid12

DIOPT Version :9

Sequence 1:	NP_001259340.1	Gene:	Trf4-1 / 31795	FlyBaseID:	FBgn0030049	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_588273.1	Gene:	cid12 / 2539423	PomBaseID:	SPCC663.12	Length:	336	Species:	Schizosaccharomyces pombe

Alignment Length:	335	Identity:	93/335 - (27%)
Similarity:	166/335 - (49%)	Gaps:	36/335 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 PYGEGVIGLHEEIEHFYQYVLPTPCEHAIRNEVVKRIEAVVHSIWPQAVVEIFGSFRTGLFLPTS 327
            |:.|..:..:..:..|.::|.|...|...|..::::::..:..:...|.::::||...|..|..|
pombe    12 PWNEEGLSDNARLYSFLEFVSPKIEELKYRKLLLEKLQTHIREVVLDAELQVYGSMYIGTTLSIS 76

  Fly   328 DIDLVVLGLWEKLPLRTLEFE-----LVSRGIAEACTVRVLDKASVPIIKLTDRETQVKVDISFN 387
            |:|:.:     |.| |..|.|     :|.|...:| .......|.||.|.|.| .:.:.||::|.
pombe    77 DVDVSL-----KSP-RVGELEKRRVTMVLRKYLDA-DADFHSSARVPRINLVD-VSGIGVDLTFG 133

  Fly   388 MQSGVQSAELIKKFKRDYPVLEKLVLVLKQFLLLRDLNEVFTGGISSYSLILMCISFLQM--HPR 450
            .....::|||.|.:..::|:..:|:::||.:|..|||..|..|||:|.:|..|.|.:|:|  |.:
pombe   134 NDKACRTAELQKAYNEEHPIFGRLLMLLKHWLFERDLENVHHGGIASCALSYMLIGWLEMRFHKK 198

  Fly   451 GIYHDTANLGVLLLEFFELYGRRFNYMKIGISIKNGGRYMPKDELQRDMVDGHRPSLLCIEDPLT 515
            ||..:...:..||.:||..:|..:.| ::.:.....|:.:||  ||:..::..:|:||.||||:.
pombe   199 GIDSEVQPIRALLQKFFYFWGVEWTY-ELFVLRPLTGQIVPK--LQKGWLNEVQPNLLSIEDPID 260

  Fly   516 PGNDIGRSSYGVFQVQQAFKCAYRVLALAVSPLNLLGIDPRVNSILGRIIHITDDVIDYREWIRE 580
            ..||||:.|:.:..::.||          |:..|.|..|....|...    ||:|.:    ::.:
pombe   261 RNNDIGKQSFQISMIKAAF----------VASANELLSDKTWFSTFA----ITEDEM----FLCK 307

  Fly   581 NFEHLVVVDR 590
            .||:::...|
pombe   308 QFENVINTKR 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trf4-1	NP_001259340.1	NT_PAP_TUTase	291..401	CDD:143392	30/114 (26%)
Trf4-1	NP_001259340.1	PAP_assoc	458..518	CDD:281779	18/59 (31%)
cid12	NP_588273.1	TRF4	1..336	CDD:227585	93/335 (28%)
		NT_PAP_TUTase	41..147	CDD:143392	30/113 (27%)
		PAP_assoc	206..263	CDD:281779	18/59 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2219
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940