DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trf4-1 and Tut4

DIOPT Version :9

Sequence 1:	NP_001259340.1	Gene:	Trf4-1 / 31795	FlyBaseID:	FBgn0030049	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_036019916.1	Gene:	Tut4 / 230594	MGIID:	2445126	Length:	1660	Species:	Mus musculus

Alignment Length:	1061	Identity:	189/1061 - (17%)
Similarity:	302/1061 - (28%)	Gaps:	387/1061 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 NTITNTTNNTGNNSSAKPYLSRPYSSLNRVLNFRADSLEILQ-QQQQQQQLNGTTQR-------- 127
            :|:.......|..||.||..|...::...:|...|:.:.:.: |..:..:...|:||
Mouse   738 STMDPKKKEKGKLSSKKPVKSDCSATNCCILGESAEKIHMERGQPAKHDETEFTSQRCIVDNDSL 802

  Fly   128 ------------NSTNINTTSGGSTSSSADSTTNRDNNSPANSSSTN--GPGAGTGTSTGAGGTG 178
                        :|::::|.|||| .....|...:.:.:|:.:|...  ......||..||...|
Mouse   803 LVNELGLANHGQDSSSLSTASGGS-DLKQKSAEKQGDLTPSETSLKKELSQCICIGTPDGAESAG 866

  Fly   179 T-----------------NSPATTASSTAATTTGPATSMSDTSNNPPQSTTTPASRTNSIYYNPS 226
            |                 |..||:.:..|...|   :.:.|..|.|.|..
Mouse   867 TDCRSNLEMDSSHQIVCNNVSATSCNCKATEVT---SDLVDEDNLPSQEL--------------- 913

  Fly   227 RKKRPENKAGGAHYYMNNHMEM-----------IAKYKG-------EPWRKPDYPYGEGVIGLHE 273
                         ||:.:...:           |.|..|       |.:||.|......:.....
Mouse   914 -------------YYVFDKFILTSGKPPTIVCSICKKDGHSKNDCPEDFRKIDLKPLPPMTNRFR 965

  Fly   274 EI-----EHFYQYVLPTPC-EHAIRNEVVKRIEAVVHSIWPQ-AVVEIFGSFRTGLFLPTSDIDL 331
            ||     :..:..:.| || |...|.:::..:|..:...:.: |.:.:|||.:.|.....||:|:
Mouse   966 EILDLVCKRCFDELSP-PCSEQHNREQILIGLEKFIQKEYDEKARLCLFGSSKNGFGFRDSDLDI 1029

  Fly   332 VVL---------------------------GLWEKLPLRTLEFELVSRGIAEACTVRVLDKASVP 369
            .:.                           ||...||:.|                     |.||
Mouse  1030 CMTLEGHENAEKLNCKEIIENLAKILKRHPGLRNILPITT---------------------AKVP 1073

  Fly   370 IIKLTDRETQVKVDISFNMQSGVQSAELIKKFKRDYPVLEKLVLVLKQFLLLRDLNEVFTGGISS 434
            |:|...|.:.::.|||........:..::..:....|.::.|...:|.|....|:.:...|.:||
Mouse  1074 IVKFEHRRSGLEGDISLYNTLAQHNTRMLATYAAIDPRVQYLGYTMKVFAKRCDIGDASRGSLSS 1138

  Fly   435 YSLILMCISFLQMH------------------PRGIY---------------------------- 453
            |:.|||.:.|||..                  |..|:
Mouse  1139 YAYILMVLYFLQQRKPPVIPVLQEQINLEDIIPNEIFDGKQIPQRMVDGWNAFFFDKTEELKKRL 1203

  Fly   454 ----HDTANLGVLLLEFFELYGRRFNYMKIGISIKNGGRYMPKDELQRDMVDGHRPSLLCIEDPL 514
                .:|.:||.|.|.....|...|::.:..|||:       :.:|............:.||||.
Mouse  1204 PSLGKNTESLGELWLGLLRFYTEEFDFKEYVISIR-------QKKLLTTFEKQWTSKCIAIEDPF 1261

  Fly   515 TPGNDIGRSSYGVFQ-----VQQAFKCAYRVLALAVSPLNLLG------IDPRVNS--------- 559
            ...:::|.   ||.:     :.:||....::......|  |:|      .|.||.:
Mouse  1262 DLNHNLGA---GVSRKMTNFIMKAFINGRKLFGTPFYP--LIGREAEYFFDSRVLTDGELAPNDR 1321

  Fly   560 ---ILGRIIHITDDV-------------IDYREWIRENFEHLVVVDRISPLPTAAPTAYATANGA 608
               :.|:|.|...|.             .|..|....|.|.....|.:.            :...
Mouse  1322 CCRVCGKIGHYMKDCPKRKSSLLFRLKKKDSEEEKEGNEEEKDSRDLLD------------SRDL 1374

  Fly   609 PKYVIMPSGAVVQQLYHHPVQVPTAHGHSHAHSHSHGHAHPGAHLCQPYVTGTTVSAVTTTTTMA 673
            ..::...:|.|.::.  ..|::......|.|          .|.|.:..|....|
Mouse  1375 RCFICGDAGHVRREC--PEVKMARQRNSSVA----------AAQLVRNLVNAQQV---------- 1417

  Fly   674 VVTVGVSAGGVQQQQQQQNATAHTHSQQQTQNQSQSRHRRGSTSSGDDSEDSKDGDVVETTSSAQ 738
                   ||..|||..|...|                  |.|:...|....|.........|...
Mouse  1418 -------AGSAQQQSDQSIRT------------------RQSSECSDSPSYSPQPQPFPQNSPQP 1457

  Fly   739 EVVDIALSTPNGLANMSMP----MPVHAVGMPASN----------------------------SW 771
            ..:....|.|.....:..|    .|.|.|.||..|                            ||
Mouse  1458 SALPPPPSQPGSQPKLGPPQQGGQPPHQVQMPLYNFPQSPPAHYSPMHSMGLLPMHPLQIPAPSW 1522

  Fly   772 SGNG----NGNGNSSSSTG-SSPEI--AHIAAQEMDPELEDQQQQQQHQETSGGNGFIRPGDVGT 829
            ..:|    :..|::.|:.| :.|.|  |..||:.|  .:...........|...|..:..|.||.
Mouse  1523 PIHGPMLHSAPGSTPSNIGLNDPSIIFAQPAARPM--AIPSPSHDGHWPRTVAPNSLVNNGAVGN 1585

  Fly   830 GSNRGGGDGSGGRNYNQRNNHNSSGYYHQQYYVPPPMQQQLSKSNSSSNYHQQHHH-----SHSH 889
            ...|..|                         :.||:..:          |...|.     |..:
Mouse  1586 SEPRFRG-------------------------LNPPIPWE----------HAPRHFPLVPASWPY 1615

  Fly   890 GNHSHRQQHHHQQQHHHQQRP 910
            |.|   |...||.....|.:|
Mouse  1616 GLH---QNFMHQGNPRFQPKP 1633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trf4-1	NP_001259340.1	NT_PAP_TUTase	291..401	CDD:143392	24/137 (18%)
Trf4-1	NP_001259340.1	PAP_assoc	458..518	CDD:281779	14/59 (24%)
Tut4	XP_036019916.1	rad2	<2..>366	CDD:273166
		TUTase	285..621	CDD:408858
		PAP_assoc	648..697	CDD:397761
		TRF4	946..>1289	CDD:227585	71/374 (19%)
		NT_PAP_TUTase	988..1106	CDD:143392	24/138 (17%)
		AIR1	<1304..>1393	CDD:227414	14/102 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810