DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trf4-1 and Tut7

DIOPT Version :9

Sequence 1:	NP_001259340.1	Gene:	Trf4-1 / 31795	FlyBaseID:	FBgn0030049	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001360893.1	Gene:	Tut7 / 214290	MGIID:	2387179	Length:	1534	Species:	Mus musculus

Alignment Length:	383	Identity:	80/383 - (20%)
Similarity:	132/383 - (34%)	Gaps:	123/383 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 YQYVLPTPCEHAIRNEVVKRIEAVVHSIWPQAVVEIFGSFRTGLFLPTSDIDLVVLGLWEKLPLR 343
            |:...||..|...|..:.:.:|:.:...:|...:.:|||.:.|.....||:|:.:
Mouse  1005 YKDFSPTIVEDQAREHIRQNLESFIKQDFPGTKLSLFGSSKNGFGFKQSDLDVCM---------- 1059

  Fly   344 TLEFELVSRGIAEACTV----RVLDK------------ASVPIIKLTDRETQVKVDISFNMQSGV 392
            |:.....:.|:....|:    |||.|            |.|||:|.....:.::||||......:
Mouse  1060 TINGHETAEGLDCVRTIEELARVLRKHSGLRNILPITTAKVPIVKFFHLRSGLEVDISLYNTLAL 1124

  Fly   393 QSAELIKKFKRDYPVLEKLVLVLKQFLLLRDLNEVFTGGISSYSLILMCISFLQMHP-------R 450
            .:..|:..:....|.::.|...:|.|..:.|:.:...|.:|||:..||.:.|||...       :
Mouse  1125 HNTRLLSAYSAIDPRVKYLCYTMKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQQRSPPVIPVLQ 1189

  Fly   451 GIY--------------------------------HDTANLGVLLLEFFELYGRRFNYMKIGISI 483
            .||                                .:|..:|.|.|.....|...|::.:..|||
Mouse  1190 EIYKGEKKPEILVDGWNIYFFDQINELPTCWPEYGKNTEPVGQLWLGLLRFYTEEFDFKEHVISI 1254

  Fly   484 KNGGRYMPKDELQRDMVDGHRPSLL------------CIEDPLTPGNDIGRSSYGVFQ-----VQ 531
            :                   |.|||            .||||....:::|.   |:.:     :.
Mouse  1255 R-------------------RKSLLTTFKKQWTSKYIVIEDPFDLNHNLGA---GLSRKMTNFIM 1297

  Fly   532 QAFKCAYRVLALAV------SPLNL-------------LGIDPRVNSILGRIIHITDD 570
            :||....||..:.|      :|..|             |..:.|...|.|:|.|...|
Mouse  1298 KAFINGRRVFGIPVKGFPKDNPSKLAYFFDPDVLTEGELAPNDRCCRICGKIGHFMKD 1355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trf4-1	NP_001259340.1	NT_PAP_TUTase	291..401	CDD:143392	27/125 (22%)
Trf4-1	NP_001259340.1	PAP_assoc	458..518	CDD:281779	16/71 (23%)
Tut7	NP_001360893.1	TUTase	205..539	CDD:408858
		PAP_assoc	550..599	CDD:397761
		2A1904	<673..>910	CDD:273344
		TRF4	975..>1306	CDD:227585	68/332 (20%)
		ZnF_C2HC	1342..1357	CDD:197667	5/14 (36%)
		TUTF7_u4	1365..1446	CDD:406924
		ZnF_C2HC	1448..1464	CDD:197667
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810