DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trf4-1 and Tent4a

DIOPT Version :9

Sequence 1:	NP_001259340.1	Gene:	Trf4-1 / 31795	FlyBaseID:	FBgn0030049	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_006517250.1	Gene:	Tent4a / 210106	MGIID:	2682295	Length:	732	Species:	Mus musculus

Alignment Length:	905	Identity:	324/905 - (35%)
Similarity:	420/905 - (46%)	Gaps:	241/905 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDPFVGWFQKEQEGPSLCTWLKIWETNAQEMGALLNQQLQQATTINGSTSSSSSSSNSGNNNNNN 65
            |||.|.|.|.||:||:...|::||||:             |.....||..:|..
Mouse     1 MDPRVAWIQPEQKGPANALWMQIWETS-------------QGVGRGGSGFASYF----------- 41

  Fly    66 NNNIINNTITNTTNNTGNNSSAKPYLSRP------------------YSSLNRVLNFRADSLEIL 112
               .:|:...:|....|....|.|....|                  ..:|...|...|||...|
Mouse    42 ---CLNSPALDTAAAPGAAGRAAPAAGGPGPAPAASSPPPAPGPAALPPALLTALGPAADSARRL 103

  Fly   113 QQQQQQQQLNGTTQRNSTNINTTSGGSTSSSADSTTNRDNNSPANSSSTNGPGAGTGTSTGAGGT 177
            .:              |.:::::| .|:||:|:|.|    .||..|||::     :.||.|..|:
Mouse   104 HK--------------SPSLSSSS-SSSSSNAESGT----ESPGCSSSSS-----SSTSLGRAGS 144

  Fly   178 GTNSPATTASSTAATTTGPATSMSDTSNNPPQSTTTPASRTNSIYYNPSRKKRPENKAG--GAHY 240
            | .:..:.|...|....||..|             |||.......::|.|:|| ||||.  |.:|
Mouse   145 G-RTFFSFADGAAHAHPGPRGS-------------TPAGSPPQHQFHPGRRKR-ENKASTYGLNY 194

  Fly   241 YMNNHMEMI----------AKYKGEPWRKPDYPYGEGVIGLHEEIEHFYQYVLPTPCEHAIRNEV 295
            .::......          |...|.||:  ...|..|:.||||||..||.::.|.|.|.|:|.||
Mouse   195 LLSGSRAATLSGGGGPGAQAARPGTPWK--SRAYSPGIQGLHEEIIDFYNFMSPCPEEAAMRREV 257

  Fly   296 VKRIEAVVHSIWPQAVVEIFGSFRTGLFLPTSDIDLVVLGLWEKLPLRTLEFELVSRGIAEACTV 360
            |||||.||..:||.|.|:|||||.|||:||||||||||.|.||:.||:.||..|....:||.|::
Mouse   258 VKRIETVVKDLWPTADVQIFGSFSTGLYLPTSDIDLVVFGKWERPPLQLLEQALRKHNVAEPCSI 322

  Fly   361 RVLDKASVPIIKLTDRETQVKVDISFNMQSGVQSAELIKKFKRDYPVLEKLVLVLKQFLLLRDLN 425
            :|||||:||||||||:||:|||||||||::||::||.||.:.:.|.:|..|:||||||||.||||
Mouse   323 KVLDKATVPIIKLTDQETEVKVDISFNMETGVRAAEFIKNYMKKYSLLPYLILVLKQFLLQRDLN 387

  Fly   426 EVFTGGISSYSLILMCISFLQMHPR-GIYHDTANLGVLLLEFFELYGRRFNYMKIGISIKNGGRY 489
            |||||||||||||||.|||||:||| .......|||:||:||||||||.|||:|.||.||.||.|
Mouse   388 EVFTGGISSYSLILMAISFLQLHPRIDARRADENLGMLLVEFFELYGRNFNYLKTGIRIKEGGAY 452

  Fly   490 MPKDELQRDMVDGHRPSLLCIEDPLTPGNDIGRSSYGVFQVQQAFKCAYRVLALAVSPLNLLGID 554
            :.|:|:.:.|..|:|||:|||||||.||||:||||||..||:|.|..||.||:.|||||.....:
Mouse   453 IAKEEIMKAMTSGYRPSMLCIEDPLLPGNDVGRSSYGAMQVKQVFDYAYIVLSHAVSPLARSYPN 517

  Fly   555 PRVNSILGRIIHITDDVIDYREWIRENFEHLVVVDRISPLP-----TAAPTAYATANGAPKYVIM 614
            ....|.|||||.:|.:|||||.||:|.:.     .||.|.|     ........|.||.......
Mouse   518 RDSESTLGRIIKVTQEVIDYRRWIKEKWG-----SRILPSPDLDNRIKIKERITTCNGEQMQSRE 577

  Fly   615 PSGAVVQQLYHHPVQVPTAHGHSHAHSHSHGHAHPGAHLCQPYVTGTTVSAVTTTTTMAVVTVGV 679
            ||                                      .||....|:|    .::..:::.|.
Mouse   578 PS--------------------------------------SPYTQRLTLS----LSSPQLLSSGS 600

  Fly   680 SAGGVQQQQQQQNATAHTHSQQQTQNQSQSRHRRGSTSSGDDSEDSKDGDVVETTSSAQEVVDIA 744
            ||..|                              |:.||.|                  :..:.
Mouse   601 SASSV------------------------------SSLSGSD------------------ITRVT 617

  Fly   745 LSTPN-GLANMSMPMP--------------VHAVGMPASNSWSGNGNGNGNSSSSTGSSPEIAHI 794
            :..|. |:|    |:|              ||:|..||..|          :|.:..|||.:.|.
Mouse   618 IPPPTLGVA----PVPCRQAGVDGTTSLKAVHSVTSPAIPS----------ASPNPLSSPHLYHK 668

  Fly   795 AAQEMDPELEDQQQQQQHQETSGGNGFIRPGDVGTGSNRGGGDGSGGRNYN----QRNNH 850
            ....|...::.     .|..|.|| |:   ..||:|:.|......|...||    :|..|
Mouse   669 QHNGMKLSMKG-----SHNHTQGG-GY---SSVGSGAVRPPVGNRGHHQYNRTGWRRKKH 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trf4-1	NP_001259340.1	NT_PAP_TUTase	291..401	CDD:143392	73/109 (67%)
Trf4-1	NP_001259340.1	PAP_assoc	458..518	CDD:281779	39/59 (66%)
Tent4a	XP_006517250.1	TRF4	233..>538	CDD:227585	193/304 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830718
Domainoid	1	1.000	136	1.000	Domainoid score	I4907
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.831874	Normalized mean entropy	S2207
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1016712at2759
OrthoFinder	1	1.000	-	-		FOG0002099
OrthoInspector	1	1.000	-	-		otm42852
orthoMCL	1	0.900	-	-		OOG6_101092
Panther	1	1.100	-	-	LDO	PTHR23092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2219
SonicParanoid	1	1.000	-	-		X1551
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.690