DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trf4-1 and cid-1

DIOPT Version :9

Sequence 1:	NP_001259340.1	Gene:	Trf4-1 / 31795	FlyBaseID:	FBgn0030049	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_498099.1	Gene:	cid-1 / 175707	WormBaseID:	WBGene00019629	Length:	1425	Species:	Caenorhabditis elegans

Alignment Length:	558	Identity:	111/558 - (19%)
Similarity:	197/558 - (35%)	Gaps:	157/558 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 KPYLSRPYSSLNRVLNFRADSLEILQQ------------QQQQQQLNGTTQRNSTNINTTSGGST 140
            |.:::| :...| |:....||.||.::            ::.::.|..::|:|.....|:...||
Worm   784 KKFINR-WKKAN-VIILSEDSSEIDEKTKAADSNVSEIAEKLEETLKISSQKNIDVAVTSMPVST 846

  Fly   141 SSSADSTTNRDNNSPANSSSTNGPGAG----------TGTSTGAGGTGTNSP------------- 182
            ....:..|...|.:|....:...|...          ..:...:....|.||
Worm   847 EIKPEPITKLSNEAPVKIKNVAQPQCDLIEAPQESLMNESMMESSFDETESPMKTPIVQKPVKQN 911

  Fly   183 ATTASSTAATTTGPATSMSD------TSNNPPQSTTTPASRTNSIYYNPS--------RKKRPEN 233
            ||...||.:|........|:      .||.....:.:.:.:.:..:|..|        ..:....
Worm   912 ATFGKSTISTVIPDKQFCSEEFFIKLNSNLKDIVSKSKSLKPSDFHYEFSTDLFCGDFEMEMKCT 976

  Fly   234 KAGGAHYYMNNHMEMIAKYKGEPWRKPDYPYGEGVIGLHEEIEHFYQYVLPTPCEHAIRNEVVKR 298
            ...|:|...|..|..|...|....|.|     |.:..:.:.|:.:|        ...|.:|  :|
Worm   977 HCDGSHCVENCPMMEIPPIKKYQARTP-----EDLKDIDDMIDKYY--------HENILDE--RR 1026

  Fly   299 IEAVVHSI-----------WPQAVVEIFGSFRTGLFLPTSDIDLVV-LGLWEKLPLRTLEFELVS 351
            ::.:.|.|           .....:..|||..|||.:..||||:.: .|..:..|......|::.
Worm  1027 LKMLDHKIDELQSFLRKNYREDVTLTTFGSVMTGLSVNCSDIDICLRFGDGDVPPKDLTAKEVIQ 1091

  Fly   352 R--GIAEAC----TVRVLDKASVPIIKLTDRETQVK--------VDISFNMQSGVQSAELIKKF- 401
            :  .:...|    .|:.:..|.|||:|.     |||        ||||:.....:.:..|:|::
Worm  1092 KTESVLRKCHLVKRVQAIVTAKVPIVKF-----QVKLSNGAIIDVDISYYNILAIYNTALLKEYS 1151

  Fly   402 -----KRDYPVLEKLVLVLKQFLLLRDLNEVFTGGISSYSLILMCISFLQ-----MHPRGIYHD- 455
                 ||    ..||.|.:|.:....::.:...|.:|||..::|.||:||     :.|| :..|
Worm  1152 LWTPDKR----FAKLALFVKTWAKNCEIGDASRGSLSSYCHVIMLISYLQNCDPPVLPR-LQEDF 1211

  Fly   456 -------------------------------TANLGVLLLEFFELYGRRFNYMKIGISIKNGGRY 489
                                           ..:...||:.:|:.|. ||::....:..:   |.
Worm  1212 RSDNRERRLVDNWDTSFAQVETSLLQRWPKNKESCAQLLIGYFDYYS-RFDFRNFVVQCR---RE 1272

  Fly   490 MPKDELQRDMVDGHRPSLLCIEDPLTPGNDIGRSSYGV 527
            |...:::::.     |..||:|||....:::   |.||
Worm  1273 MILSKMEKEW-----PRPLCVEDPFDLSHNL---SSGV 1302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trf4-1	NP_001259340.1	NT_PAP_TUTase	291..401	CDD:143392	34/135 (25%)
Trf4-1	NP_001259340.1	PAP_assoc	458..518	CDD:281779	14/59 (24%)
cid-1	NP_498099.1	PAP_assoc	574..625	CDD:367682
		NT_PAP_TUTase	1029..1151	CDD:143392	31/126 (25%)
		TRF4	1034..>1317	CDD:227585	65/291 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810