DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trf4-1 and TENT4A

DIOPT Version :9

Sequence 1:	NP_001259340.1	Gene:	Trf4-1 / 31795	FlyBaseID:	FBgn0030049	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_008930.2	Gene:	TENT4A / 11044	HGNCID:	16705	Length:	792	Species:	Homo sapiens

Alignment Length:	918	Identity:	322/918 - (35%)
Similarity:	425/918 - (46%)	Gaps:	207/918 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDPFVGWFQKEQEGPSLCTWLKIWETNAQEMGALLNQQLQQATTINGS--------------TSS 51
            |||.|.|.|.||:||:...|::||||:             |.....||              |::
Human     1 MDPRVAWIQPEQKGPANALWMQIWETS-------------QGVGRGGSGFASYFCLNSPALDTAA 52

  Fly    52 SSSSSNSGNNNNNNNNNIINNTITNTTNNTGNNSSAKPYLSRPYSSLNRVLNFRADSLEILQQQQ 116
            ::.::..|                     :|....|.|..|.|..............|..|....
Human    53 AAGAAGRG---------------------SGGLGPALPAASPPPPGPTAPAALPPALLTALGPAA 96

  Fly   117 QQQQLNGTTQRNSTNINTTSGGSTSSSADSTTNRD--NNSPANSSSTNGPGAGTGTSTGAGGTGT 179
            :     |..:.:.:...::|..|:||:|:|.|...  ::|.::|:|...||.      |.||...
Human    97 E-----GARRLHKSPSLSSSSSSSSSNAESGTESPGCSSSSSSSASLGRPGG------GRGGAFF 150

  Fly   180 NSPATTASSTAATTTGPATSMSDTSNNPPQSTTTPASRTNSIYYNPSRKKRPENKAG--GAHYYM 242
            |. |..|.|...|..|          :|......||...:...::|.|:|| ||||.  |.:|.:
Human   151 NF-ADGAPSAPGTANG----------HPGPRGPAPAGSPSQHQFHPGRRKR-ENKASTYGLNYLL 203

  Fly   243 NNHMEMI----------AKYKGEPWRKPDYPYGEGVIGLHEEIEHFYQYVLPTPCEHAIRNEVVK 297
            :......          |...|.||:  ...|..|:.||||||..||.::.|.|.|.|:|.||||
Human   204 SGSRAAALSGGGGPGAQAPRPGTPWK--SRAYSPGIQGLHEEIIDFYNFMSPCPEEAAMRREVVK 266

  Fly   298 RIEAVVHSIWPQAVVEIFGSFRTGLFLPTSDIDLVVLGLWEKLPLRTLEFELVSRGIAEACTVRV 362
            |||.||..:||.|.|:|||||.|||:||||||||||.|.||:.||:.||..|....:||.|:::|
Human   267 RIETVVKDLWPTADVQIFGSFSTGLYLPTSDIDLVVFGKWERPPLQLLEQALRKHNVAEPCSIKV 331

  Fly   363 LDKASVPIIKLTDRETQVKVDISFNMQSGVQSAELIKKFKRDYPVLEKLVLVLKQFLLLRDLNEV 427
            ||||:||||||||:||:|||||||||::||::||.||.:.:.|.:|..|:||||||||.||||||
Human   332 LDKATVPIIKLTDQETEVKVDISFNMETGVRAAEFIKNYMKKYSLLPYLILVLKQFLLQRDLNEV 396

  Fly   428 FTGGISSYSLILMCISFLQMHPR-GIYHDTANLGVLLLEFFELYGRRFNYMKIGISIKNGGRYMP 491
            |||||||||||||.|||||:||| .......|||:||:||||||||.|||:|.||.||.||.|:.
Human   397 FTGGISSYSLILMAISFLQLHPRIDARRADENLGMLLVEFFELYGRNFNYLKTGIRIKEGGAYIA 461

  Fly   492 KDELQRDMVDGHRPSLLCIEDPLTPGNDIGRSSYGVFQVQQAFKCAYRVLALAVSPLNLLGIDPR 556
            |:|:.:.|..|:|||:|||||||.||||:||||||..||:|.|..||.||:.|||||.....:..
Human   462 KEEIMKAMTSGYRPSMLCIEDPLLPGNDVGRSSYGAMQVKQVFDYAYIVLSHAVSPLARSYPNRD 526

  Fly   557 VNSILGRIIHITDDVIDYREWIRENF-----------EHLVVVDRISPLPTAAPTAYATANGAPK 610
            ..|.|||||.:|.:|||||.||:|.:           ..:.:.:||           ||.||...
Human   527 AESTLGRIIKVTQEVIDYRRWIKEKWGSKAHPSPGMDSRIKIKERI-----------ATCNGEQT 580

  Fly   611 YVIMPSGAVVQQLYHHPVQVPTAHGHSHAHSHSHGHAHPGAHLCQPYV--TGTTVSAVTTTTTMA 673
            ....|.....|:|                          ...|..|.:  :|::.|:|:
Human   581 QNREPESPYGQRL--------------------------TLSLSSPQLLSSGSSASSVS------ 613

  Fly   674 VVTVGVSAGGVQQQQQQQNATAHTHSQQQTQNQSQSRHRRGSTSSGDDSEDSKDGDVVETTSSAQ 738
                  |..|..........|  |.|..|...|:.:....|..:    :.....|....|||..
Human   614 ------SLSGSDVDSDTPPCT--TPSVYQFSLQAPAPLMAGLPT----ALPMPSGKPQPTTSRT- 665

  Fly   739 EVVDIALSTPNGLANMSMPMP----------------------VHAVGMPASNSWSGNGNGNGNS 781
                 .:.|.|.....::|.|                      ||.:..||..|          :
Human   666 -----LIMTTNNQTRFTIPPPTLGVAPVPCRQAGVEGTASLKAVHHMSSPAIPS----------A 715

  Fly   782 SSSTGSSPEIAHIAAQEMDPELEDQQQQQQHQETSGGNGFIRPGDVGTGSNRGGGDGSGGRNYN- 845
            |.:..|||.:.|.....|...::.     .|..|.|| |:   ..||:|..|......|...||
Human   716 SPNPLSSPHLYHKQHNGMKLSMKG-----SHGHTQGG-GY---SSVGSGGVRPPVGNRGHHQYNR 771

  Fly   846 ---QRNNH 850
               :|..|
Human   772 TGWRRKKH 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trf4-1	NP_001259340.1	NT_PAP_TUTase	291..401	CDD:143392	73/109 (67%)
Trf4-1	NP_001259340.1	PAP_assoc	458..518	CDD:281779	39/59 (66%)
TENT4A	NP_008930.2	PAP_assoc	240..>545	CDD:332051	193/304 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140745
Domainoid	1	1.000	136	1.000	Domainoid score	I4926
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.831874	Normalized mean entropy	S2207
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1016712at2759
OrthoFinder	1	1.000	-	-		FOG0002099
OrthoInspector	1	1.000	-	-		otm40779
orthoMCL	1	0.900	-	-		OOG6_101092
Panther	1	1.100	-	-	LDO	PTHR23092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2219
SonicParanoid	1	1.000	-	-		X1551
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.690