DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trf4-1 and tent4b

DIOPT Version :9

Sequence 1:	NP_001259340.1	Gene:	Trf4-1 / 31795	FlyBaseID:	FBgn0030049	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_004913600.1	Gene:	tent4b / 100491336	XenbaseID:	XB-GENE-990067	Length:	660	Species:	Xenopus tropicalis

Alignment Length:	838	Identity:	302/838 - (36%)
Similarity:	402/838 - (47%)	Gaps:	214/838 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDPFVGWFQKEQEGPSLCTWLKIWETNAQEMGALLNQQLQQATTINGSTSSSSSSSNSGNNNNNN 65
            |||.:.|||.||.|||...|::||||.........|.....:.|.:.|:||||...
Frog     1 MDPRIAWFQPEQLGPSNSLWMQIWETTQGLRNLYFNHNSPASPTHSASSSSSSICE--------- 56

  Fly    66 NNNIINNTITNTTNNTGNNSSAKPYLSRPYSSLNRVLNFRADSLEILQQQQQQQQLNGTTQRNST 130
                 .||:...:....||.|               |..:.|.:.|
Frog    57 -----TNTMYRDSGTAQNNQS---------------LGEQRDYIPI------------------- 82

  Fly   131 NINTTSGGSTSSSADSTTNRDNNSPANSSSTNGPGAGTGTSTGAGGTGTNSPATTASSTAATTTG 195
                           .|||.:||...:.            |.||.|.|.:
Frog    83 ---------------ETTNNNNNQLLSQ------------SPGAWGKGHD--------------- 105

  Fly   196 PATSMSDTSNNPPQSTTTPASRTNSIYYNPSRKKRPENKAGGAHYYMNNHME------MIAKYKG 254
                                      :.|.:::|| :|||  :.:.:|..::      ::..|.|
Frog   106 --------------------------HINRNKRKR-DNKA--STFGLNCLLQCSAGSSVVGLYNG 141

  Fly   255 EPWRKPDYPYGEGVIGLHEEIEHFYQYVLPTPCEHAIRNEVVKRIEAVVHSIWPQAVVEIFGSFR 319
            .||:  ...|.|.||||||||..||:|:.|.|.|..:|.|||.|||.|:..:||.|.|:|||||:
Frog   142 TPWK--TRTYSEEVIGLHEEIMDFYKYMSPRPEEEKMRMEVVNRIENVIKELWPNADVQIFGSFK 204

  Fly   320 TGLFLPTSDIDLVVLGLWEKLPLRTLEFELVSRGIAEACTVRVLDKASVPIIKLTDRETQVKVDI 384
            |||:||||||||||.|.||.|||.|||..|....:|:..:|:|||||:||||||||..|:|||||
Frog   205 TGLYLPTSDIDLVVFGKWENLPLWTLEEALRKHKVADENSVKVLDKATVPIIKLTDSFTEVKVDI 269

  Fly   385 SFNMQSGVQSAELIKKFKRDYPVLEKLVLVLKQFLLLRDLNEVFTGGISSYSLILMCISFLQMHP 449
            |||:|:||::|:|||.|.:.||||..||||||||||.|||||||||||.||||.||.:||||:||
Frog   270 SFNVQNGVKAAQLIKDFIKKYPVLPYLVLVLKQFLLQRDLNEVFTGGIGSYSLFLMAVSFLQLHP 334

  Fly   450 RGIYHDT----ANLGVLLLEFFELYGRRFNYMKIGISIKNGGRYMPKDELQRDMVDGHRPSLLCI 510
            |   .|.    ||.||||:||||||||.|||:|.||.||.||.|:.|||:|::|:||:|||:|.|
Frog   335 R---EDACSLDANYGVLLIEFFELYGRHFNYVKTGIRIKEGGSYVAKDEVQKNMLDGYRPSMLYI 396

  Fly   511 EDPLTPGNDIGRSSYGVFQVQQAFKCAYRVLALAVSPLNLLGIDPRVNSILGRIIHITDDVIDYR 575
            ||||.||||:||||||..||:|||..||.||:.||||:.....:....|||||||.:|.:|:.||
Frog   397 EDPLQPGNDVGRSSYGAMQVKQAFDYAYVVLSHAVSPIAKFYPNNETESILGRIIRVTQEVVTYR 461

  Fly   576 EWIRENFEH--------------LVVVDRISPLPTAAPTAYATANGAPKYVIMPSGAVVQQLYHH 626
            |||.:::..              |:.:|:.:...|...|              .||.|..::..
Frog   462 EWISKHWGQKMKSESAYNGNEVTLINLDKCNNNVTEENT--------------NSGQVKNKISE- 511

  Fly   627 PVQVPTAHGHSHAHSHSHGHAHPGAHLCQPYVTGTTVSAVTTTTTMAVVTVGVSAGGVQQQQQQQ 691
                 |...||   |:|               :|...|:.:|.::.:.|...:....:|......
Frog   512 -----TLCKHS---SNS---------------SGPLSSSSSTLSSSSDVKKVIKRLCIQDSDGTP 553

  Fly   692 NATAHTHSQQQTQNQSQSRHRRGSTSSGDDSEDSKDGDVVETTSSAQEVVDIALSTPNGLANMSM 756
            ..|:...|.:|| :.|:..|:...|||...|..|:   .:::.||:.........|.....:.|
Frog   554 FKTSKQPSCRQT-SDSRMGHQESCTSSLQPSGKSQ---TIQSISSSNNSTKAQHGTTRLFRSTS- 613

  Fly   757 PMPVHAVGMPASNSWSGNGNGNGNSSSSTGSSPEIAHIAAQEMDPELEDQQQQQQHQE 814
                      :|.|:.|:.|      :|.|:|....|       |.....|.||.|.:
Frog   614 ----------SSKSFQGHPN------TSQGTSVPSRH-------PLSGKAQHQQYHSK 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trf4-1	NP_001259340.1	NT_PAP_TUTase	291..401	CDD:143392	71/109 (65%)
Trf4-1	NP_001259340.1	PAP_assoc	458..518	CDD:281779	41/59 (69%)
tent4b	XP_004913600.1	TRF4	149..>428	CDD:227585	186/281 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	126	1.000	Domainoid score	I5372
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1016712at2759
OrthoFinder	1	1.000	-	-		FOG0002099
OrthoInspector	1	1.000	-	-		oto102972
Panther	1	1.100	-	-	O	PTHR23092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2219
SonicParanoid	1	1.000	-	-		X1551
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.050