DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32260 and ndl

DIOPT Version :9

Sequence 1:	NP_728942.1	Gene:	CG32260 / 317943	FlyBaseID:	FBgn0052260	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_523947.2	Gene:	ndl / 38738	FlyBaseID:	FBgn0002926	Length:	2616	Species:	Drosophila melanogaster

Alignment Length:	437	Identity:	116/437 - (26%)
Similarity:	175/437 - (40%)	Gaps:	111/437 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 SCQDARSRPGSCLPLTSCPQLMQEYQGQANE---FHTFLG--QSICGFDGSTFMVCCATD---RS 249
            :|.:.|......:.:|.....| .:...|:|   :|.:.|  ..:|........:.|..|   |.
  Fly   994 NCLNGRDEEQCSMLVTDVADHM-SHGASASEGYLYHNYRGDWHPVCNNGEKWAALACQMDENSRM 1057

  Fly   250 GNARSRKDVFVTTAAPFGFF--------HFSPLSGG-----STATPMVFQPTPPLSQVVSPSFYP 301
            .::.|....|.|...|..|.        ||:....|     |....:.:...||:.
  Fly  1058 DHSASLNVSFQTLTLPGPFIEPSLHAGVHFAQACHGRNSHDSLVDHVAYVKCPPMQ--------- 1113

  Fly   302 PPPPPPPNNAPRESATCGISGATS---------------------NRVVGGMEARKGAYPWIAAL 345
                            ||:...:|                     .|:|||.......:|::.|:
  Fly  1114 ----------------CGLPSKSSMLEHSKRVRRAVSDSKEIVGDGRIVGGSYTSALQWPFVVAI 1162

  Fly   346 GYFEENNRNALKFLCGGSLIHSRYVITSAHCI---NPMLTLVRLGAHDLSQPAESGAMDLR-IRR 406
                  .||. ||.|||::...|::|::|||:   ......||.|.  |.:.:.|.|..:: :..
  Fly  1163 ------YRNG-KFHCGGTIYSDRWIISAAHCVINYGKYFYEVRAGL--LRRSSYSPATQIQPVSH 1218

  Fly   407 TVVHEHFDLNSISNDIALIELNVVGALPGN--ISPICLPEAAKFMQQDFVGMNPF------VAGW 463
            .|||:.::..|:.||::|:.|  :..|..|  :.|||||:..:....|.....|.      |.||
  Fly  1219 VVVHQAYERRSMRNDLSLLRL--LNPLQFNRWVKPICLPDKGRTTVGDDWIWGPVEHTLCTVVGW 1281

  Fly   464 GAVKHQGVTSQVLRDAQVPIVSRHSC----EQSYKSIFQFVQFSDKVLCAG--SSSVDACQGDSG 522
            ||::.:|.:|..:|...|||  |..|    :|:.:.|           |||  ....||||||||
  Fly  1282 GAIREKGPSSDPMRQVIVPI--RKKCTDPEDQASEDI-----------CAGDPDGGRDACQGDSG 1333

  Fly   523 GPLMMPQLEGNVYRFYLLGLVSFGYECARPNFPGVYTRVASYVPWIK 569
            |||....: .|...|||.|:||.|..||||...||||||..|:.|::
  Fly  1334 GPLFCRSV-SNPDEFYLAGVVSHGNGCARPQEFGVYTRVTLYLDWLE 1379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32260	NP_728942.1	CLIP	194..244	CDD:288855	9/54 (17%)
		Tryp_SPc	327..568	CDD:214473	89/258 (34%)
		Tryp_SPc	328..571	CDD:238113	89/260 (34%)
ndl	NP_523947.2	LDLa	891..927	CDD:238060
		Tryp_SPc	1144..1377	CDD:214473	89/257 (35%)
		Tryp_SPc	1145..1379	CDD:238113	89/258 (34%)
		LDLa	1399..1430	CDD:238060
		Metaviral_G	1448..1600	CDD:118131
		LDLa	1710..1743	CDD:238060
		LDLa	1776..1811	CDD:238060
		DUF1986	2041..2158	CDD:286432
		LDLa	2309..2339	CDD:197566
		LDLa	2350..2383	CDD:197566
		LDLa	2421..2457	CDD:238060
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24258
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100