Protein Alignment CG32260 and TMPRSS9

DIOPT Version :10

• Sequence 1: NP_728942.1
• Gene: CG32260 / 317943
• FlyBaseID: FBgn0052260
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001382442.1
• Gene: TMPRSS9 / 360200
• HGNCID: 30079
• Length: 1093
• Species: Homo sapiens
• Alignment Length: 699
• Identity: 168/699 - (24%)
• Similarity: 249/699 - (35%)
• Gaps: 268/699 - (38%)

  Fly    60 PIGPLIPPQPALPSTPAVIPTFQPTPPNPQTPVTPPLITTSSSTTSSTTSTTGLTTTTTAGTTLP 124
            |:.|.:.|.||.|||        ..|.:|::||          .::.|.|...|:|......|:|
Human   475 PLAPTMAPAPAAPST--------AWPTSPESPV----------VSTPTKSMQALSTVPLDWVTVP 521

  Fly   125 LPMPTCPSQPL---------------------VCLTGGARPLPNCPCIDPR-------------- 154
             .:..|.::|.                     |.|..|:|.......:..|
Human   522 -KLQECGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHTKV 585

  Fly   155 QQQNSPL-------LSSTGPQIGSDMMVFMPLNSGRRRRRRRRPQSCQDARSRPG---------- 202
            :|..:.|       |..:..:||...:|..||.:                   ||
Human   586 EQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYN-------------------PGILDFDLAVLE 631

  Fly   203 -------------SCLPLT--------SC---------------PQLMQEYQ-GQANEFHTFLGQ 230
                         .||||.        .|               |:|:|:.. |       .:.|
Human   632 LASPLAFNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVG-------IIDQ 689

  Fly   231 SIC----GFDGSTFMVC----------CATDRSGNARSRKDVFVTTAAPFGFFHFS--------- 272
            ..|    .|..:..|:|          |..|..|.....:       || |.|:.:
Human   690 KTCSVLYNFSLTDRMICAGFLEGKVDSCQGDSGGPLACEE-------AP-GVFYLAGIVSWGIGC 746

  Fly   273 ----------------------------PLSGGST-------------------ATPMVFQPTP- 289
                                        |:|..||                   |||.  :|||
Human   747 AQVKKPGVYTRITRLKGWILEIMSSQPLPMSPPSTTRMLATTSPRTTAGLTVPGATPS--RPTPG 809

  Fly   290 ------------PLSQVVSPSFYPPPPPPPPNNAPRESAT------CGISGATSNRVVGGMEARK 336
                        .||.|.:.:....|.|..|     |:.|      ||::.|...|:|||..|.:
Human   810 AASRVTGQPANSTLSAVSTTARGQTPFPDAP-----EATTHTQLPDCGLAPAALTRIVGGSAAGR 869

  Fly   337 GAYPWIAALGYFEENNRNALKFLCGGSLIHSRYVITSAHCI----NPMLTLVRLGAHDLSQPAES 397
            |.:||..:|......:|      ||..|:..|:::::|||.    :|......||...||  ...
Human   870 GEWPWQVSLWLRRREHR------CGAVLVAERWLLSAAHCFDVYGDPKQWAAFLGTPFLS--GAE 926

  Fly   398 GAMDLRIRRTVVHEHFDLNSISNDIALIELNVVGALPGN--ISPICLPEAAKFMQQDFVGMNPFV 460
            |.:: |:.|...|..::|.::..|:||:||  .|.:..:  :.||||||.|.....   |....:
Human   927 GQLE-RVARIYKHPFYNLYTLDYDVALLEL--AGPVRRSRLVRPICLPEPAPRPPD---GTRCVI 985

  Fly   461 AGWGAVKHQGVTSQVLRDAQVPIVSRHSCEQSYKSIFQFVQFSDKVLCAG--SSSVDACQGDSGG 523
            .|||:|:..|..::.|:.|.|.::|..:|.:.|.     ||.|.::||||  ...||:|.||:||
Human   986 TGWGSVREGGSMARQLQKAAVRLLSEQTCRRFYP-----VQISSRMLCAGFPQGGVDSCSGDAGG 1045

  Fly   524 PLMMPQLEGNVYRFYLLGLVSFGYECARPNFPGVYTRVASYVPWIKKHI 572
            ||...:..|   |:.|.|:.|:||.|.||:|||||||||:...||.:||
Human  1046 PLACREPSG---RWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWIGQHI 1091

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32260	NP_728942.1	CLIP	194..244	CDD:463440	16/110 (15%)
		Tryp_SPc	328..571	CDD:238113	88/250 (35%)
TMPRSS9	NP_001382442.1	SEA	66..>127	CDD:460188
		LDLa	188..223	CDD:238060
		Tryp_SPc	236..465	CDD:214473
		Tryp_SPc	538..768	CDD:238113	36/263 (14%)
		Pneumo_att_G	<717..>867	CDD:114270	32/164 (20%)
		Tryp_SPc	861..1087	CDD:238113	86/247 (35%)