DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32260 and F10

DIOPT Version :9

Sequence 1:	NP_728942.1	Gene:	CG32260 / 317943	FlyBaseID:	FBgn0052260	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_000495.1	Gene:	F10 / 2159	HGNCID:	3528	Length:	488	Species:	Homo sapiens

Alignment Length:	426	Identity:	112/426 - (26%)
Similarity:	171/426 - (40%)	Gaps:	105/426 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 CQDARSRPGSC---LPLTSCPQLMQEYQGQANEFHTFLGQSICGFD-GSTFMVC--------CAT 246
            ||:    .|.|   |...:| ..::.::|:..|..|   :.:|..| |.....|        |:.
Human    95 CQN----QGKCKDGLGEYTC-TCLEGFEGKNCELFT---RKLCSLDNGDCDQFCHEEQNSVVCSC 151

  Fly   247 DR------SGNA---------------RSRKDVFVTTAAPFGFFHFSPLSGGSTATPMVFQP--T 288
            .|      :|.|               |.::.|...|:           |.|.....:.::|  .
Human   152 ARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATS-----------SSGEAPDSITWKPYDA 205

  Fly   289 PPLSQVVSP----SFYPPPPPPPPNNAPRESATCGISGATSNRVVGGMEARKGAYPWIAALGYFE 349
            ..|....:|    .|....|....||.              .|:|||.|.:.|..||.|.|  ..
Human   206 ADLDPTENPFDLLDFNQTQPERGDNNL--------------TRIVGGQECKDGECPWQALL--IN 254

  Fly   350 ENNRNALKFLCGGSLIHSRYVITSAHCINPMLTL-VRLGAHDLSQPAESGAMDLRIRRTVVHEHF 413
            |.|..    .|||:::...|::|:|||:...... ||:|..:..| .|.|.....:...:.|..|
Human   255 EENEG----FCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQ-EEGGEAVHEVEVVIKHNRF 314

  Fly   414 DLNSISNDIALIELNVVGALPGNISPICLPE---AAKFMQQDFVGMNPFVAGWGAVKHQGVTSQV 475
            ...:...|||::.|........|::|.||||   |...:.....|:   |:|:|....:|..|..
Human   315 TKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI---VSGFGRTHEKGRQSTR 376

  Fly   476 LRDAQVPIVSRHSCEQSYKSIFQFVQFSDKVLCAG--SSSVDACQGDSGGPLMMPQLEGNVYRF- 537
            |:..:||.|.|:||:.|...|     .:..:.|||  :...||||||||||        :|.||
Human   377 LKMLEVPYVDRNSCKLSSSFI-----ITQNMFCAGYDTKQEDACQGDSGGP--------HVTRFK 428

  Fly   538 ---YLLGLVSFGYECARPNFPGVYTRVASYVPWIKK 570
               ::.|:||:|..|||....|:||:|.:::.||.:
Human   429 DTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDR 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32260	NP_728942.1	CLIP	194..244	CDD:288855	13/61 (21%)
		Tryp_SPc	327..568	CDD:214473	81/250 (32%)
		Tryp_SPc	328..571	CDD:238113	82/253 (32%)
F10	NP_000495.1	GLA	25..85	CDD:214503
		EGF_CA	86..122	CDD:238011	7/31 (23%)
		FXa_inhibition	129..164	CDD:317114	7/34 (21%)
		O-glycosylated at one site	183..203		4/30 (13%)
		Tryp_SPc	235..464	CDD:238113	82/251 (33%)
		O-glycosylated at one site	476..485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D402896at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920