DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32232 and TUBGCP6

DIOPT Version :9

Sequence 1:	NP_729045.1	Gene:	CG32232 / 317930	FlyBaseID:	FBgn0052232	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_065194.3	Gene:	TUBGCP6 / 85378	HGNCID:	18127	Length:	1819	Species:	Homo sapiens

Alignment Length:	755	Identity:	141/755 - (18%)
Similarity:	236/755 - (31%)	Gaps:	302/755 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 RDLTSSKYGSLHTVRSQIPMEQSKPLDTSDYNYSRELNLGKVAVKENFTIKGAKMELELNV---- 263
            ||...|.:|:|  |.|:              .|..::.||...|.:|..:.|..:::..:|
Human   208 RDTRVSLFGAL--VHSR--------------TYDMDVRLGLPPVPDNADLSGLAIKVPPSVDQWE 256

  Fly   264 -------------VQNKPSA-------------------------------EKPALVDFFKNESD 284
                         .|::||.                               |:|.|.:..::..|
Human   257 DEGFQSASNLTPDSQSEPSVTPDVDLWEAALTYEASKRRCWERVGCPPGHREEPYLTEAGRDAFD 321

  Fly   285 MLYRIQTNWWQVDISVYNQAHILASNFCQGYADILIFQLWESQASIRKLSEEHQLLSEL--IVLF 347
            ...|:.          ..:..:||....|....:|:              :|.:|:.::  :::.
Human   322 KFCRLH----------QGELQLLAGGVLQAPQPVLV--------------KECELVKDVLNVLIG 362

  Fly   348 FASANCRSFKILNDNWEFRADEPLTCALKQLQEGPHLG----EIIKSLKQMRHLRELIETYAVKG 408
            ..||.            |...:|....:  ::.|.|:.    |.|.||     |.|:.|    .|
Human   363 VVSAT------------FSLCQPAQAFV--VKRGVHVSGASPESISSL-----LSEVAE----YG 404

  Fly   409 IRYDRLKTLTFFSVALRQLLRPVIEFLVHFERRL-----TSGLE-------------PATLQHFI 455
            ..|.|   |:.||      |:||::.|  :.:.|     ||||.             |.||.
Human   405 TCYTR---LSHFS------LQPVLDSL--YSKGLVFQAFTSGLRRYLQYYRACVLSTPPTLS--- 455

  Fly   456 ETSRGHLETIKLLYELSQNKNQELHSLRSL-----------------------KTLDTLFTKS-- 495
                  |.||..|:   :...::|..|..|                       |.|..|:.::
Human   456 ------LLTIGFLF---KKLGRQLRYLAELCGVGAVLPGTCGGGPRAAFPTGVKLLSYLYQEALH 511

  Fly   496 --SQKTQPKLLRSLSASLLLHTVRAYCKFLDNWWSTGDFADYHEEFPFE---------------- 542
              |.:..|.||     |||..:...|.:|:.:|..:|.|.|.:.||..:
Human   512 NCSNEHYPVLL-----SLLKTSCEPYTRFIHDWVYSGVFRDAYGEFMIQVNHEYLSFRDKLYWTH 571

  Fly   543 -KIVTDERTE--------------YVLRKSLMQTELQNSELFRIIQRHLLESSD----GVAILYD 588
             .::..:..|              ||..|::...:|       ...||.|..||    .:::::.
Human   572 GYVLISKEVEDCVPVFLKHIAHDIYVCGKTINLLKL-------CCPRHYLCWSDVPVPRISVIFS 629

  Fly   589 SRTISEFH-----------------TLHGIEPEIRLHNSLIDAVIGEIAPYQI--KAIEASHYVP 634
            ...:.|..                 ::...|.|:|:          |||..::  .|.||:..|.
Human   630 LEELKEIEKDCAVYVGRMERVARHSSVSKEEKELRM----------EIAKQELIAHAREAASRVL 684

  Fly   635 DILQQLQSTD--------HDGIRRLFYSFHMETRPDPRKPAGHSINELLRNFLTCADYTPITEII 691
            ..|...|.::        .:..:||...|   .:...|:.|..  .|.|.:     |::...|:.
Human   685 SALSDRQMSERMALDARKREQFQRLKEQF---VKDQERRQAAR--QEELDD-----DFSYARELR 739

  Fly   692 SQEFQRLLNRRTRLVNSYISGLLQEFQGYKVVRHLRSVFLLWNYDHFRSEFEFFFEFLRRKHLVE 756
            .:| :||.:....|.......|:..:.........|....||.....|      .|..|.:.|:|
Human   740 DRE-RRLKSLEEELERKARQALVDHYSKLSAEAARREQKALWRIQRHR------LESARLRFLLE 797

  Fly   757 ATNKLKHIVLCQDFTLGHMFKVCVTEAH----PEFICLRV 792
            ..   |||        ..|.| .|:|||    |..:.|.|
Human   798 DE---KHI--------QEMLK-AVSEAHQPQEPPDVLLSV 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32232	NP_729045.1	Spc97_Spc98	382..>559	CDD:282045	55/256 (21%)
TUBGCP6	NP_065194.3	GCP_N_terminal	353..610	CDD:407574	61/314 (19%)
		DUF5401	<630..834	CDD:375164	47/235 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	810..889		6/16 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	929..951
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1000..1023
		9 X 27 AA tandem repeats	1027..1269
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1271..1412
		Spc97_Spc98	1513..1816	CDD:398000
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110079at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010