Protein Alignment t-Grip128 and Tubgcp5

DIOPT Version :10

• Sequence 1: NP_729045.1
• Gene: t-Grip128 / 317930
• FlyBaseID: FBgn0052232
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: NP_666302.2
• Gene: Tubgcp5 / 233276
• MGIID: 2178836
• Length: 1024
• Species: Mus musculus
• Alignment Length: 1141
• Identity: 199/1141 - (17%)
• Similarity: 378/1141 - (33%)
• Gaps: 350/1141 - (30%)

  Fly     5 ERQKVIERNLPHLVSVLLGSPIDDKKNDNGQVSVEPATFDKCLTYARCHIADPNVVDCDPDAVWD 69
            :||  :|.::..||..:.|  :.|:.:.|.|:::     |...:..|.|    ..:|.:...|..
Mouse    12 DRQ--LEHDVCELVRQVTG--LQDEADPNFQLAL-----DFVWSNFRFH----RFLDVNSHKVEK 63

  Fly    70 TMNQFLERFRIENLSVFGDTFNQLANVILNHPICMNHK-QRNIHWRLLDFVL----SVNYKTFVS 129
            |:....|:|.|.:......::.:|....||..:....| :.:.|:.:|..:|    |.:...:|.
Mouse    64 TIEGIYEKFTIHSDLNKAASWKRLTKEFLNASLPSTEKIKTDAHYSILSLLLCLSDSPSNSNYVE 128

  Fly   130 IRRNLPEMEQKRKNILEALQMATESSQV--DPK-DKNNTKCVADTEDQLIHKKSQKPKSPRKKLT 191
            ..|   |.|.::|:..:..:...|..::  .|. |..|....:|.||      :|:|.|  ::.:
Mouse   129 TPR---EKEVEKKDDFDWGKYLMEGEEIGLGPNIDTPNWSEDSDDED------AQQPLS--REDS 182

  Fly   192 PDQIQRLCDEIRDLTSSKYGSLHTVRSQIPMEQSKPLDTSDYNY-------------SRELNLGK 243
            ..|:.|                            .||:..|:|.             ||.. |.:
Mouse   183 GIQVDR----------------------------TPLEEQDHNRKGGPQVCWEDEPDSRSW-LEQ 218

  Fly   244 VAVKENFTIKGAKMELELNVVQNKPSAEKPALVDFFKNESDMLYRIQTNWWQVDISVYNQAHILA 308
            ..|.:.:|.:..::....::..|     ..|:.|.....||.||.........:..|..:...|.
Mouse   219 HVVHQYWTTRRFRIPHSAHLHSN-----LAAVWDQHLYSSDPLYVPDDRVVVTETQVIRETLWLL 278

  Fly   309 SNFCQGYADILIFQLWESQASIRKLSEEHQLLSELIVLFFASANCRSFKILNDNWEFRADEPLTC 373
            |    |...:.||||.:.:.::|         :.:||.....:..||
Mouse   279 S----GVKKMFIFQLIDGKVTVR---------NNIIVTHLTHSCLRS------------------ 312

  Fly   374 ALKQLQEGPHLGEIIKSLKQMRHLRELIETYAVKGIRYDRL----------------KTLTFFSV 422
            .|:|:..   .|:::      ..|:|.|:  .|.|...:.|                :|...|..
Mouse   313 VLEQIAA---YGQVV------FRLQEFID--EVMGHSSESLPPGNGPIPKKQPDAPFRTYQAFMW 366

  Fly   423 ALRQLLRPVIEFLVHFERRLTSGLEPATLQHFIETSRGHLETIKLLYELSQNKNQEL-----HSL 482
            ||.:......|.|...|:.:.|.....||...:......|..:|:|.::......|:     :.:
Mouse   367 ALYKYFINFKEELTDIEKCVISSDTTITLAIVVNKLAPRLAQLKVLDKVFSTGVAEVPPDTRNVV 431

  Fly   483 RSLKTLDTLFT---------KSSQKTQPKLLRSLSASLLLHTVRAYCKFLDNWWSTGDFADYHEE 538
            |:...|:||:.         ::|::|.     ||..||.:.|||.|.:.:|.|...|...|...|
Mouse   432 RASHLLNTLYKAILEYDNVGEASEQTV-----SLLFSLWVETVRPYLQTVDEWIVHGHLWDGARE 491

  Fly   539 FPFEK---IVTDER----TEYVLRKSLMQTELQNSELFRIIQRHLLESSDGVAILYDSRTISEFH 596
            |..::   :..:.|    ..|.|.....:||.::.          :..|...:...|....|..|
Mouse   492 FIIQRNKNVPVNHRDFWYATYTLYSVSEKTENEDK----------VSDSASASSGSDQGPSSRQH 546

  Fly   597 TLHG-IEPEIR----------------------------------LHNSLIDAVIGEIAPYQIKA 626
            |:.. ::|.::                                  |:...::::       |::.
Mouse   547 TMVSFLKPVLKQIIMAGKSMQLLKNLNCAEGPACQAAARDAERKSLYTLFLESI-------QLRL 604

  Fly   627 IEASHYVPDILQQLQSTD-------------------HDGIRRL-FYSFHMETRPDPRKPAGHSI 671
            .......|.|:.:.|:|.                   ||.:..: |...::|......|.||..|
Mouse   605 QHGEDSAPHIVNEDQTTKENLIKMQSIAERHLELDDIHDPLLAINFARLYLEQSDFHEKFAGGDI 669

  Fly   672 NELLRNFLTCADYTPITEIISQEFQRLL---------NRRTRLVNSYISGLLQEFQGYKVVRHLR 727
                     |.|.:. ..:..|.|:..|         .:......:.:..|.::|:..:.::.:|
Mouse   670 ---------CVDRSS-ESVTCQTFELTLRSCLYPHIDKQYLHCCGNLMQTLKRDFRLVEYLQAMR 724

  Fly   728 SVFLLWNYDHFRSEFEFFFEFLRRKHLVEATNKLKHIVLCQDFTLGHMFKVCVTEAHPE---FIC 789
            :.||:...|.....:...|:.:|.|...:..:.|.  |..|:         .|.:.:||   .:.
Mouse   725 NFFLMEGGDTMYDFYTSIFDKIREKETWQNVSFLN--VQLQE---------AVGQRYPEDSLRLS 778

  Fly   790 LRVRN-DTLLNR---------------------IISQQQMDMMNSCFRLLLNLNFSHYRLNHL-- 830
            :...| ||...:                     :||.:...:.|..|.|||.:.::.|.|:.|
Mouse   779 ISFENVDTTKKKLPVHILDGLTLSYKVPWPVDIVISVECQKIYNQVFLLLLQIKWAKYSLDVLLF 843

  Fly   831 ---------------------------PPFHYCKYE--RLF----KALRSIQISLISVFEEHLSH 862
                                       ||....:.:  |:|    |.:..:. ||.:.....:.|
Mouse   844 GELGNAAERSQAKEDIPRDQDTPSQFGPPKESLRQQIHRMFLLRVKLMHFVN-SLHNYIMTRILH 907

  Fly   863 PCKLFRKMQNLDSYNSELNEFTSLTQLRRNQEIFGLHIR-------KYLLEEQFAC---SLPEIL 917
            ...|        .:..::.|...|.||.:      :|.|       :.||.|:.:.   ::.::|
Mouse   908 STGL--------EFQHQVEEAKDLDQLIK------IHYRYLSTIHDRCLLREKVSFVKEAIMKVL 958

  Fly   918 TLSKVFCLRWETTRALVDEYRSQKATSTFERRYKLL 953
            .|:.:|...|:...........:|..|.|:..:..|
Mouse   959 NLALMFAEGWQAGLGAWQMESIEKMESDFKNCHMFL 994

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
t-Grip128	NP_729045.1	GCP5_NTD	10..121	CDD:454848	23/115 (20%)
Tubgcp5	NP_666302.2	GCP5_NTD	15..108	CDD:439339	20/103 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	153..203		15/85 (18%)
		GCP_N_terminal	271..588	CDD:465456	66/373 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	523..545		3/31 (10%)
		GCP_C_terminal	716..1017	CDD:461187	52/305 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	853..873		1/19 (5%)