Protein Alignment t-Grip128 and TUBGCP5

DIOPT Version :10

• Sequence 1: NP_729045.1
• Gene: t-Grip128 / 317930
• FlyBaseID: FBgn0052232
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: NP_001341301.1
• Gene: TUBGCP5 / 114791
• HGNCID: 18600
• Length: 1061
• Species: Homo sapiens
• Alignment Length: 1117
• Identity: 203/1117 - (18%)
• Similarity: 369/1117 - (33%)
• Gaps: 361/1117 - (32%)

  Fly    11 ERNLPHLVSVLLGSPIDDKKNDNGQVSVEPATFDKCLTYARCHIADPNVVDCDPDAVWDTMNQFL 75
            ||::..||..:.|  :.|:.:.|         |...|.:|..:......:|.:...:..|:....
Human    16 ERDVRELVRGVAG--LQDEADPN---------FQLALNFAWSNFRFHRFLDVNSHKIEKTIEGIY 69

  Fly    76 ERFRIENLSVFGDTFNQLANVILNHPI-CMNHKQRNIHWRLLDFVL----SVNYKTFVSIRRNLP 135
            |:|.|.:......::.:|....||.|: .:...:.:.|:.:|..:|    |.:..::|...|| .
Human    70 EKFVIHSDLSKAASWKRLTEEFLNAPLPSIKEIKTDAHYSILSLLLCLSDSPSNSSYVETPRN-K 133

  Fly   136 EMEQKRKNILEALQMATESSQVDP----------KDKNNTKCVADTEDQLIHKKSQKPKSPRKKL 190
            |:|:|.........|..|...:.|          .::.|.:.....||..|    |..::|.::
Human   134 EVEKKDDFDWGKYLMEDEEMDIGPYMDTPNWSEESEEENDQQPLSREDSGI----QVDRTPLEE- 193

  Fly   191 TPDQIQRL--CDEIRDLTSSKYGSLHTVRSQIPMEQSKPLDTSDYNYSRELNLGKVAVKENFTIK 253
             .||.::|  |                    |..:..:|.|.|...:.        .|.:.:|.:
Human   194 -QDQNRKLDPC--------------------ISWKADEPDDRSWLEHH--------VVHQYWTAR 229

  Fly   254 GAKMELELNVVQNKPSAEKPALVDFFKNESDMLYRIQTNWWQVDISVYNQAHILASNFCQGYADI 318
            .::....|::..|     ..|:.|.....||.||.........:..|..:...|.|    |...:
Human   230 PSQFPHSLHLHSN-----LAAVWDQHLYSSDPLYVPDDRVLVTETQVIRETLWLLS----GVKKL 285

  Fly   319 LIFQLWESQASIRKLSEEHQLLSELIVLFFASANCRSFKILNDNWEFRADEPLTCALKQLQEGPH 383
            .||||.:.:.::|         :.:||.....:..||                  .|:|:..
Human   286 FIFQLIDGKVTVR---------NNIIVTHLTHSCLRS------------------VLEQIAA--- 320

  Fly   384 LGEIIKSLKQ-----MRHLRELI----------ETYAVKGIRYDRLKTLTFFSVALRQLLRPVIE 433
            .|:::..|::     |.|..|.:          .|.|       ..:|...|..||.:......|
Human   321 YGQVVFRLQEFIDEVMGHSSESMLPGSGSVPKKSTEA-------PFRTYQAFMWALYKYFISFKE 378

  Fly   434 FLVHFERRLTSGLEPATLQHFIETSRGHLETIKLLYELSQNKNQEL-----HSLRSLKTLDTLFT 493
            .|...|:.:.:.....||...::.....|..:|:|:::......|:     :.:|:...|:||:.
Human   379 ELAEIEKCIINNDTTITLAIVVDKLAPRLSQLKVLHKVFSTGVAEVPPDTRNVVRASHLLNTLYK 443

  Fly   494 ---------KSSQKTQPKLLRSLSASLLLHTVRAYCKFLDNWWSTGDFADYHEEFPFEK---IVT 546
                     ::|::|.     ||..||.:.|||.|.:.:|.|...|...|...||..::   :..
Human   444 AILEYDNVGEASEQTV-----SLLFSLWVETVRPYLQTVDEWIVHGHLWDGAREFIIQRNKNVPV 503

  Fly   547 DER----TEYVLRKSLMQTELQNSELFRIIQRHLLESSDGVAIL--YDSRTISEFHTLHG-IEPE 604
            :.|    ..|.|.....:||  |.|          :.||..:..  .|....|..||:.. ::|.
Human   504 NHRDFWYATYTLYSVSEKTE--NEE----------KMSDNASASSGSDQGPSSRQHTMVSFLKPV 556

  Fly   605 IR----------------------------------LHNSLIDAVIGEIAPYQIKAIEASHYVPD 635
            ::                                  |:...:::|       |.:........|.
Human   557 LKQIIMAGKSMQLLKNLQCAESTTCQAGARDAERKSLYTLFLESV-------QSRLRHGEDSTPQ 614

  Fly   636 ILQQLQSTD-------------------HDGIRRL-FYSFHMETRPDPRKPAGHSINELLRNFLT 680
            :|.:.|:|.                   ||.:..: |...::|......|.||..:
Human   615 VLTEQQATKENLMKMQSIAESHLELDDVHDPLLAINFARMYLEQSDFHEKFAGGDV--------- 670

  Fly   681 CADYTPITEIISQEFQRLLNRRTRLV----NSYI---SGLLQEF-QGYKVVRHL---RSVFLLWN 734
            |.|.:. ..:..|.|:  |..|:.|.    ..|:   ..|:|.. :.|::|.:|   |:.||:..
Human   671 CVDRSS-ESVTCQTFE--LTLRSCLYPHIDKQYLDCCGNLMQTLKKDYRLVEYLQAMRNFFLMEG 732

  Fly   735 YDHFRSEFEFFFEFLRRKHLVEATNKLKHIVLCQDFTLGHMFKVCVTEAHPE---FICLRVRN-D 795
            .|.....:...|:.:|.|...:..:.|.  |..|:         .|.:.:||   .:.:...| |
Human   733 GDTMYDFYTSIFDKIREKETWQNVSFLN--VQLQE---------AVGQRYPEDSSRLSISFENVD 786

  Fly   796 TLLNR---------------------IISQQQMDMMNSCFRLLLNLNFSHYRLNHLPPFHYCKYE 839
            |...:                     :||.:...:.|..|.|||.:.::.|.|:.|
Human   787 TAKKKLPVHILDGLTLSYKVPWPVDIVISLECQKIYNQVFLLLLQIKWAKYSLDVL--------- 842

  Fly   840 RLFKALRSIQISLISVFE-----EHLSHP-------------------------CKLFRKMQNLD 874
             ||.       .|:|..|     |.|.|.                         .||...:.:|.
Human   843 -LFG-------ELVSTAEKPRLKEGLIHEQDTVAQFGPQKEPVRQQIHRMFLLRVKLMHFVNSLH 899

  Fly   875 SY-------------NSELNEFTSLTQLRRNQEIFGLHIR-------KYLLEEQFAC---SLPEI 916
            :|             ..::.|...|.||.:      :|.|       :.||.|:.:.   ::.::
Human   900 NYIMTRILHSTGLEFQHQVEEAKDLDQLIK------IHYRYLSTIHDRCLLREKVSFVKEAIMKV 958

  Fly   917 LTLSKVFCLRWE 928
            |.|:.:|...|:
Human   959 LNLALMFADGWQ 970

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
t-Grip128	NP_729045.1	GCP5_NTD	10..121	CDD:454848	22/114 (19%)
TUBGCP5	NP_001341301.1	GCP5_NTD	15..108	CDD:439339	19/102 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	155..203		10/53 (19%)
		GCP_N_terminal	272..578	CDD:465456	68/363 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	522..546		8/35 (23%)
		GCP_C_terminal	717..1000	CDD:461187	53/288 (18%)