DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IntS4 and INTS4

DIOPT Version :9

Sequence 1:	NP_572488.1	Gene:	IntS4 / 31793	FlyBaseID:	FBgn0026679	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	NP_291025.3	Gene:	INTS4 / 92105	HGNCID:	25048	Length:	963	Species:	Homo sapiens

Alignment Length:	1086	Identity:	366/1086 - (33%)
Similarity:	551/1086 - (50%)	Gaps:	189/1086 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALAIKKRVGTYVETVDGSPP-----VKKLRLQTLAADAKGGKSGKVGNVERKLTALNQLDAYVG 60
            ||..:||||  |.|......|     .|||||      .|..||           |...:|....
Human     1 MAAHLKKRV--YEEFTKVVQPQEEIATKKLRL------TKPSKS-----------AALHIDLCKA 46

  Fly    61 NLPAGALVLPTGTPVASTGAPSTGVIGNPPAAATGAPPMTAANSRELLELLVKITDEISYEDVEM 125
            ..||.||                                     :.||:...|        .||.
Human    47 TSPADAL-------------------------------------QYLLQFARK--------PVEA 66

  Fly   126 GELKEVASKIFQLYQLQERDSDTSIRVKLLELL------SGLGCECATEQALTMIIDYFIFLLRK 184
            ..::.|...:.:.|.   :::|.|:|:|:..||      :|...:|        |:|..|.:|:.
Human    67 ESVEGVVRILLEHYY---KENDPSVRLKIASLLGLLSKTAGFSPDC--------IMDDAINILQN 120

  Fly   185 EVSQKVLAQGMMCLFRIGER-------RKHMLPISYK--TQVAHLAKEQ-------LRSGSAHTQ 233
            |.|.:||||.:..|..||.:       :..::.::.|  |..:|..:.:       |.|......
Human   121 EKSHQVLAQLLDTLLAIGTKLPENQAIQMRLVDVACKHLTDTSHGVRNKCLQLLGNLGSLEKSVT 185

  Fly   234 KNAMLVIGRFATKMEGERHYVWKLAFYIDSQDSSVRAQALHALLTLGERGSQLPAVLYKRAVEAM 298
            |:|..:..|...|:.|:         |...||..||..|:.|:|.|.|||.:|...:|.:|.:.:
Human   186 KDAEGLAARDVQKIIGD---------YFSDQDPRVRTAAIKAMLQLHERGLKLHQTIYNQACKLL 241

  Fly   299 KDDYECVRKEALQLVFMLGNRHPDYILPSDRQQEELRMIDAAFSKVCEALCDLSLQIRVLAAELL 363
            .||||.||..|:||::::...:|:.|:|.....||:|::|.||.|:|..:.|.|..:||.||:||
Human   242 SDDYEQVRSAAVQLIWVVSQLYPESIVPIPSSNEEIRLVDDAFGKICHMVSDGSWVVRVQAAKLL 306

  Fly   364 GGMTAVSREFLHQTLDKKLMSNLRRKRTAHERGARLVASGEWSSGKRWADDAPQEHLDAQSISII 428
            |.|..||..||.|||||||||:||||||||||...|.:|||:|||::|.||||:|.:|..::::|
Human   307 GSMEQVSSHFLEQTLDKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPKEEVDTGAVNLI 371

  Fly   429 ASGACGALIHGLEDEFLEVRTAAVASMCKLALSRPDFAVTSLDFLVDMFNDEIEDVRLKAIYSLT 493
            .||||||.:||||||..|||.|||.::|.||.|.|.||...|||||||||||||:|||::|:::.
Human   372 ESGACGAFVHGLEDEMYEVRIAAVEALCMLAQSSPSFAEKCLDFLVDMFNDEIEEVRLQSIHTMR 436

  Fly   494 AIAKHIVLREDQLEIMLGSLEDYSVDVREGLHLMLGACRVSTQTCLLMVVQKLLDVLAKYPQDRN 558
            .|:.:|.||||||:.:|..|||.|.|:||.||.:|....|||:..:.:.:.:||..|.|||.||:
Human   437 KISNNITLREDQLDTVLAVLEDSSRDIREALHELLCCTNVSTKEGIHLALVELLKNLTKYPTDRD 501

  Fly   559 STYACMRKIGQKHPHLVMAVAVHLLYVHPFFETPERDVEDPAYLCVLILVFNAAEHLVPIISLLP 623
            |.:.|::.:|.:||.||:.:...||..||||:|.|.|::||||:.||:|:||||:....:.:|..
Human   502 SIWKCLKFLGSRHPTLVLPLVPELLSTHPFFDTAEPDMDDPAYIAVLVLIFNAAKTCPTMPALFS 566

  Fly   624 TATHRHYAYLRDSMPNLVPQLPIEG---ASSASATHRIDSAMHQAGSSAEYLQMILSHIEEIFTM 685
            ..|.|||||||||:.:|||.|.:.|   .|||.:    .|.:.|...|.::||..|..:..:..:
Human   567 DHTFRHYAYLRDSLSHLVPALRLPGRKLVSSAVS----PSIIPQEDPSQQFLQQSLERVYSLQHL 627

  Fly   686 TDE-RLELLQTAQSNLQRLGSIDAGMYGTSNFLETFLAAQ-IQIEQMQRCASTQRSRVPLKES-L 747
            ..: ..|||:....:|||||.:.:.:.|.::|..|:|..| :.|:.:|.......:.:.||:| |
Human   628 DPQGAQELLEFTIRDLQRLGELQSELAGVADFSATYLRCQLLLIKALQEKLWNVAAPLYLKQSDL 692

  Fly   748 AA-----LIRNCLKLQHTFSGLNYGDILQVKQLRLRACALHLVLVVR-DRSQSAL-GPCQMLLQT 805
            |:     ::....|::..:||:....::.:..:||:|.||.|::..| .|....| |.|:..||.
Human   693 ASAAAKQIMEETYKMEFMYSGVENKQVVIIHHMRLQAKALQLIVTARTTRGLDPLFGMCEKFLQE 757

  Fly   806 AGDISEFIKANTKDEEEKPPVVETDMPMKESVSRDAQPDSFTRQLLIKLDGISDPKPGRVFREIL 870
            ......:..|              |:|..:        |||..:||..:..:...||..|.:.:.
Human   758 VDFFQRYFIA--------------DLPHLQ--------DSFVDKLLDLMPRLMTSKPAEVVKILQ 800

  Fly   871 PLVQQAPPLALPPANDKIRRCVANILEPCPLQSQDNVIKVTAGLIAAVPFVAEIDNLLESQKADM 935
            .:::|:..|.| |..::|.:..|.|:||.  ...||.::.|:||:.|:...|.::::.:.|.. :
Human   801 TMLRQSAFLHL-PLPEQIHKASATIIEPA--GESDNPLRFTSGLVVALDVDATLEHVQDPQNT-V 861

  Fly   936 RIKIKYPDQHMHTVVPKQSDFK---PIMTEQGEHKTNVRLRTTILLSHSVWTESSLVEIQLCLAV 997
            ::::.|||.....:.||.:||:   |     |.|    ||.|.:.|||:.|||:..||::|.||.
Human   862 KVQVLYPDGQAQMIHPKPADFRNPGP-----GRH----RLITQVYLSHTAWTEACQVEVRLLLAY 917

  Fly   998 RPGSELELC-----------------------KPAKVLFAPKPVRR 1020
            ...:.:..|                       ||.||...|||.||
Human   918 NSSARIPKCPWMEGGEMSPQVETSIEGTIPFSKPVKVYIMPKPARR 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS4	NP_572488.1	HEAT repeat	290..326	CDD:293787	13/35 (37%)
		HEAT repeat	339..414	CDD:293787	45/74 (61%)
		HEAT repeat	432..459	CDD:293787	17/26 (65%)
		HEAT repeat	468..498	CDD:293787	18/29 (62%)
		HEAT repeat	504..528	CDD:293787	13/23 (57%)
INTS4	NP_291025.3	HEAT	51..>256	CDD:224331	63/269 (23%)
		HEAT 1	66..105		8/41 (20%)
		HEAT repeat	115..143	CDD:293787	11/27 (41%)
		HEAT 2	145..183		5/37 (14%)
		HEAT repeat	155..182	CDD:293787	5/26 (19%)
		HEAT 3	190..228		15/46 (33%)
		HEAT repeat	199..221	CDD:293787	8/30 (27%)
		HEAT 4	229..263		12/33 (36%)
		HEAT repeat	233..272	CDD:293787	14/38 (37%)
		HEAT 5	277..313		16/35 (46%)
		HEAT repeat	282..311	CDD:293787	14/28 (50%)
		HEAT repeat	320..347	CDD:293787	20/26 (77%)
		HEAT repeat	360..398	CDD:293787	21/37 (57%)
		HEAT 6	369..405		22/35 (63%)
		Adaptin_N	<379..460	CDD:396262	48/80 (60%)
		HEAT 7	406..444		22/37 (59%)
		HEAT repeat	411..441	CDD:293787	18/29 (62%)
		HEAT 8	446..484		18/37 (49%)
		HEAT repeat	447..475	CDD:293787	14/27 (52%)
		HEAT repeat	486..512	CDD:293787	10/25 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142872
Domainoid	1	1.000	487	1.000	Domainoid score	I391
eggNOG	1	0.900	-	-		E1_KOG2259
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69427
Inparanoid	1	1.050	512	1.000	Inparanoid score	I1321
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49995
OrthoDB	1	1.010	-	-		D204348at33208
OrthoFinder	1	1.000	-	-		FOG0006609
OrthoInspector	1	1.000	-	-		oto90032
orthoMCL	1	0.900	-	-		OOG6_104599
Panther	1	1.100	-	-	LDO	PTHR20938
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3511
SonicParanoid	1	1.000	-	-		X4846
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800