DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IntS4 and ints4

DIOPT Version :9

Sequence 1:	NP_572488.1	Gene:	IntS4 / 31793	FlyBaseID:	FBgn0026679	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	XP_009291649.1	Gene:	ints4 / 564681	ZFINID:	ZDB-GENE-120215-81	Length:	979	Species:	Danio rerio

Alignment Length:	989	Identity:	356/989 - (35%)
Similarity:	528/989 - (53%)	Gaps:	126/989 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 AANSRELLELLVKITDEISYEDVEMGELKEVASKIFQLYQLQERDSDTSIRVKLLELL------S 159
            |.|..:.|:.|:    ..:.:.||...::.|...:.:.|.   ::||.|:|:|:..||      .
Zfish    48 ATNPTDALQYLL----SFARKPVEAESVEGVVRILLEHYY---KESDNSVRLKIASLLGLLSKTQ 105

  Fly   160 GLGCECATEQALTMIIDYFIFLLRKEVSQKVLAQGMMCLFRIGERRKHMLPISYKTQVAH----L 220
            |...:|        |:|..|..|..|.|.:||||.:..|..||.:    ||  .||.|..    :
Zfish   106 GFASDC--------IVDDAINTLNTEKSHQVLAQLLDTLLIIGTQ----LP--DKTAVIQRLIDV 156

  Fly   221 AKEQLRSGSAHTQKNAMLVIGRFAT-----------------KMEGERHYVWKLAFYIDSQDSSV 268
            |.:.|.|.....:...:.::|...|                 :....|..:..::.|...||..|
Zfish   157 ACKHLSSTYFGVRNKCLQLLGCLGTVDKPLSKETDTGAGAGAQTSAVRDVLSLISDYFQDQDPRV 221

  Fly   269 RAQALHALLTLGERGSQLPAVLYKRAVEAMKDDYECVRKEALQLVFMLGNRHPDYILPSDRQQEE 333
            |..|:.|:|.|.|||.::...:|.:|.:.:.||||.||..|:|:|::|...:|:.|:|.....||
Zfish   222 RTAAIKAMLQLHERGMKIQQTIYNQACKLLSDDYEQVRSAAVQMVWVLSQLYPESIVPIPSSNEE 286

  Fly   334 LRMIDAAFSKVCEALCDLSLQIRVLAAELLGGMTAVSREFLHQTLDKKLMSNLRRKRTAHERGAR 398
            :|::|.:|.|:|..:.|.|..:||.||:|||.|..||..||.|||||||||:||||||||||...
Zfish   287 IRLVDDSFGKICHMVSDGSWVVRVQAAKLLGSMHQVSPHFLEQTLDKKLMSDLRRKRTAHERAKE 351

  Fly   399 LVASGEWSSGKRWADDAPQEHLDAQSISIIASGACGALIHGLEDEFLEVRTAAVASMCKLALSRP 463
            |.||||:|||:|||||||:|.:|...:::|.||||||.:||||||..|||.|||.::|.||.|..
Zfish   352 LYASGEFSSGRRWADDAPKEKVDTSGVNLIDSGACGAFVHGLEDEMYEVRIAAVEALCSLAQSSR 416

  Fly   464 DFAVTSLDFLVDMFNDEIEDVRLKAIYSLTAIAKHIVLREDQLEIMLGSLEDYSVDVREGLHLML 528
            .||...|||||||||||||:|||::|:.|..|:.||.||||||:.:|..|||.|.|:||.||.:|
Zfish   417 SFAEKCLDFLVDMFNDEIEEVRLQSIHVLRQISTHITLREDQLDTVLAVLEDSSRDIREALHELL 481

  Fly   529 GACRVSTQTCLLMVVQKLLDVLAKYPQDRNSTYACMRKIGQKHPHLVMAVAVHLLYVHPFFETPE 593
            ....|||:.|:.:.:.:||..|:|||.||||.:.|::.:|.:||.||:.:...||..||:|:|||
Zfish   482 CYTNVSTKECIQLALLELLKNLSKYPTDRNSVWKCLKFLGARHPTLVLPIVPELLSTHPYFDTPE 546

  Fly   594 RDVEDPAYLCVLILVFNAAEHLVPIISLLPTATHRHYAYLRDSMPNLVPQLPIEG----ASSASA 654
            .|::||||:.||:||||||:....:.:|....|.|||||||||:.:|||.|.:.|    |||...
Zfish   547 PDMDDPAYIAVLVLVFNAAQSCPTMPALFSDHTFRHYAYLRDSLSHLVPHLRLPGRKQTASSGVE 611

  Fly   655 THRIDSAMHQAGSSAEYLQMILSHIEEIFTM-TDERLELLQTAQSNLQRLGSIDAGMYGTSNFLE 718
            ...:.|...:  |:..:||..|..:..:..: |....:||:....:|.|||.:...:.|:::|..
Zfish   612 ASGVGSGSLE--SAKNFLQDSLVRVSALQNLETPGAQDLLEFTIRDLLRLGELQTELAGSADFCA 674

  Fly   719 TFLAAQIQI-EQMQRCASTQRSRVPLKES--LAALIRNCL----KLQHTFSGLNYGDILQVKQLR 776
            |:|..|:.: :.:|....|....:.||::  ::...|..|    ||:..:|||....|..:..:|
Zfish   675 TYLRCQLLLTKALQEKLWTMAVPLCLKQNAKVSTATRQILDETYKLEFLYSGLETQQIATIHNVR 739

  Fly   777 LRACALHLVLVVRDRS--QSALGPCQMLLQTAGDISEFIKANTKDEEEKPPVVETDMPMKESVSR 839
            |:|.||.|:|..|.:.  ...||.|:..||   |:..|.:           :..|::|..:
Zfish   740 LQAKALQLILTARSKRGVDRVLGVCEKFLQ---DVESFQR-----------LFMTELPHFQ---- 786

  Fly   840 DAQPDSFTRQLLIKLDGISDPKPGRVFREILPLVQQAP--PLALPPANDKIRRCVANILEPCPLQ 902
                |||..:||..:..::..||..:.:.:...::|:.  .|.||   ::|.|..|.|:|  |..
Zfish   787 ----DSFVEKLLELMPRLTACKPLDLVKILQTTLRQSRCIHLKLP---EQIHRASATIIE--PTG 842

  Fly   903 SQDNVIKVTAGLIAAVPFVAEIDNLLESQKADMRIKIKYPDQHMHTVVPKQSDFKPIMTEQGEHK 967
            ..||.::.|:||:.|:...|.::::.:.| ..:::::.|||...|.:.||..||:    ..|..:
Zfish   843 ESDNPLRFTSGLVVALDIDATLEHVQDPQ-TTVKVQVLYPDGQSHIIHPKPGDFR----TPGPGR 902

  Fly   968 TNVRLRTTILLSHSVWTESSLVEIQLCLAVR--------------------PGSE------LELC 1006
              |||.|.:.||||.|||...:|::|.||..                    |.||      :.|.
Zfish   903 --VRLITQVYLSHSAWTEPCQIEVRLLLAYSSSSSKLSSSKPAWNESMDGLPTSESSIEGTIHLS 965

  Fly  1007 KPAKVLFAPKPVRR 1020
            ||.||...|||.||
Zfish   966 KPVKVFIMPKPARR 979

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS4	NP_572488.1	HEAT repeat	290..326	CDD:293787	14/35 (40%)
		HEAT repeat	339..414	CDD:293787	47/74 (64%)
		HEAT repeat	432..459	CDD:293787	17/26 (65%)
		HEAT repeat	468..498	CDD:293787	19/29 (66%)
		HEAT repeat	504..528	CDD:293787	13/23 (57%)
ints4	XP_009291649.1	HEAT	79..>264	CDD:224331	55/201 (27%)
		HEAT repeat	113..138	CDD:293787	10/24 (42%)
		HEAT repeat	153..184	CDD:293787	5/30 (17%)
		HEAT repeat	207..231	CDD:293787	7/23 (30%)
		HEAT repeat	243..271	CDD:293787	12/27 (44%)
		HEAT repeat	292..325	CDD:293787	15/32 (47%)
		HEAT repeat	334..371	CDD:293787	29/36 (81%)
		HEAT repeat	382..408	CDD:293787	18/25 (72%)
		HEAT repeat	421..451	CDD:293787	19/29 (66%)
		HEAT repeat	457..481	CDD:293787	13/23 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575709
Domainoid	1	1.000	514	1.000	Domainoid score	I303
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69427
Inparanoid	1	1.050	515	1.000	Inparanoid score	I1263
OMA	1	1.010	-	-		QHG49995
OrthoDB	1	1.010	-	-		D204348at33208
OrthoFinder	1	1.000	-	-		FOG0006609
OrthoInspector	1	1.000	-	-		oto39471
orthoMCL	1	0.900	-	-		OOG6_104599
Panther	1	1.100	-	-	LDO	PTHR20938
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3511
SonicParanoid	1	1.000	-	-		X4846
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940