DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IntS4 and Ints4

DIOPT Version :9

Sequence 1:	NP_572488.1	Gene:	IntS4 / 31793	FlyBaseID:	FBgn0026679	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	NP_001178558.1	Gene:	Ints4 / 308837	RGDID:	1305036	Length:	964	Species:	Rattus norvegicus

Alignment Length:	974	Identity:	346/974 - (35%)
Similarity:	531/974 - (54%)	Gaps:	110/974 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 AANSRELLELLVKITDEISYEDVEMGELKEVASKIFQLYQLQERDSDTSIRVKLLELL------S 159
            |.:..:.|:.|:    :.:.:.||...::.|...:.:.|.   :::|.|:|:|:..||      :
  Rat    47 ATSPADALQYLL----QFARKPVEAESVEGVVRILLEHYY---KENDPSVRLKIASLLGLLSKTA 104

  Fly   160 GLGCECATEQALTMIIDYFIFLLRKEVSQKVLAQGMMCLFRIGERRKHMLPISYKTQV--AHLAK 222
            |...:|        |:|..|.:|:.|.|.:||||.:..|..||.:    ||.:..|||  ..:|.
  Rat   105 GFSPDC--------IMDDAINILQNEKSHQVLAQLLDTLLAIGSK----LPENQATQVRLVDVAC 157

  Fly   223 EQLRSGSAHTQKNAMLVIG------RFATK-MEG--ERHYVWKLAFYIDSQDSSVRAQALHALLT 278
            :.|...|...:...:.::|      :..|| .||  .|.....:..|...||..||..|:.|:|.
  Rat   158 KHLTDTSHGVRNKCLQLLGNLGSLEKSVTKDTEGLTARDVQKIIGDYFSDQDPRVRTAAIKAMLQ 222

  Fly   279 LGERGSQLPAVLYKRAVEAMKDDYECVRKEALQLVFMLGNRHPDYILPSDRQQEELRMIDAAFSK 343
            |.|||.:|...:|.:|.:.:.||||.||..|:||::::...:|:.|:|.....||:|::|.||.|
  Rat   223 LHERGLKLHQTIYNQACKLLSDDYEQVRSAAVQLIWVVSQLYPESIVPIPSSNEEIRLVDDAFGK 287

  Fly   344 VCEALCDLSLQIRVLAAELLGGMTAVSREFLHQTLDKKLMSNLRRKRTAHERGARLVASGEWSSG 408
            :|..:.|.|..:||.||:|||.|..||..||.|||||||||:||||||||||...|.:|||:|||
  Rat   288 ICHMVSDGSWVVRVQAAKLLGSMEQVSSHFLEQTLDKKLMSDLRRKRTAHERAKELYSSGEFSSG 352

  Fly   409 KRWADDAPQEHLDAQSISIIASGACGALIHGLEDEFLEVRTAAVASMCKLALSRPDFAVTSLDFL 473
            ::|.||||:|.:|..::::|.||||||.:||||||..|||.|||.::|.||.|.|.||...||||
  Rat   353 RKWGDDAPKEEIDTGAVNLIESGACGAFVHGLEDEMYEVRIAAVEALCMLAQSSPSFAEKCLDFL 417

  Fly   474 VDMFNDEIEDVRLKAIYSLTAIAKHIVLREDQLEIMLGSLEDYSVDVREGLHLMLGACRVSTQTC 538
            |||||||||:|||::|:::..|:.:|.||||||:.:|..|||.|.|:||.||.:|....|||:..
  Rat   418 VDMFNDEIEEVRLQSIHTMRKISNNITLREDQLDTVLAVLEDSSRDIREALHELLCCTNVSTKEG 482

  Fly   539 LLMVVQKLLDVLAKYPQDRNSTYACMRKIGQKHPHLVMAVAVHLLYVHPFFETPERDVEDPAYLC 603
            :.:.:.:||..|.|||.||:|.:.|::.:|.:||.||:.:...||..||||:|.|.|::||||:.
  Rat   483 IHLALVELLKNLTKYPTDRDSIWKCLKFLGSRHPTLVLPLVPELLSTHPFFDTAEPDMDDPAYIA 547

  Fly   604 VLILVFNAAEHLVPIISLLPTATHRHYAYLRDSMPNLVPQLPIEGASSASATHRIDSAMHQAGSS 668
            ||:|:||||:....:.:|....|.|||||||||:.:|||.|.:.|....|:....:...|: ..|
  Rat   548 VLVLIFNAAKTCPTMPALFSDHTLRHYAYLRDSLSHLVPALRLPGRKLVSSAVPSNITPHE-DPS 611

  Fly   669 AEYLQMILSHIEEIFTMTDE-RLELLQTAQSNLQRLGSIDAGMYGTSNFLETFLAAQ-IQIEQMQ 731
            .::||..|..:..:..:..: ..|||:....:|||||.:.:.:.|.::|..|:|..| :.|:.:|
  Rat   612 QQFLQQSLERVYSVQHLDPQGAQELLEFTIRDLQRLGELQSELAGVADFSATYLQCQLLLIKALQ 676

  Fly   732 RCASTQRSRVPLKES-LAA-----LIRNCLKLQHTFSGLNYGDILQVKQLRLRACALHLVLVVR- 789
            .......:.:.||:| ||:     ::....|::..:||:....::.:..:||:|.||.|::..|
  Rat   677 EKLWNVAAPLYLKQSDLASAAAKQIMEETYKMEFMYSGVENKQVVIIHHMRLQARALQLLVTART 741

  Fly   790 DRSQSAL-GPCQMLLQTAGDISE-FIKANTKDEEEKPPVVETDMPMKESVSRDAQPDSFTRQLLI 852
            .|....| |.|:..||....... ||               .|:|..:        |||..:||.
  Rat   742 TRGVDPLFGMCEKFLQEVDFFQRCFI---------------ADLPHLQ--------DSFVDKLLD 783

  Fly   853 KLDGISDPKPGRVFREILPLVQQAPPLALPPANDKIRRCVANILEPCPLQSQDNVIKVTAGLIAA 917
            .:..:...|||.|.:.:..:::|:..|.| |..::|.:..|.|:||.  ...||.::.|:||:.|
  Rat   784 LMPRLMASKPGEVIKILQTMLRQSTFLHL-PLPEQIHKASATIIEPA--GESDNPLRFTSGLVVA 845

  Fly   918 VPFVAEIDNLLESQKADMRIKIKYPDQHMHTVVPKQSDFK---PIMTEQGEHKTNVRLRTTILLS 979
            :...|.::::.:.|.: :::::.|||.....:.||.:||:   |     |.|    ||.|.:.||
  Rat   846 LDVDATLEHVQDPQNS-VKVQVLYPDGQAQMIHPKPADFRNPGP-----GRH----RLLTQVYLS 900

  Fly   980 HSVWTESSLVEIQLCLAVRPGSE-----------------------LELCKPAKVLFAPKPVRR 1020
            |:.|||...||::|.||...|:.                       :...||.||...|||.||
  Rat   901 HTAWTEPCQVEVRLLLAYNSGARIPKSPWLEGSEMSPQVETSIEGTIPFSKPVKVYIMPKPARR 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS4	NP_572488.1	HEAT repeat	290..326	CDD:293787	13/35 (37%)
		HEAT repeat	339..414	CDD:293787	45/74 (61%)
		HEAT repeat	432..459	CDD:293787	17/26 (65%)
		HEAT repeat	468..498	CDD:293787	18/29 (62%)
		HEAT repeat	504..528	CDD:293787	13/23 (57%)
Ints4	NP_001178558.1	HEAT	52..>257	CDD:224331	64/223 (29%)
		HEAT repeat	112..137	CDD:293787	10/24 (42%)
		HEAT repeat	149..183	CDD:293787	6/33 (18%)
		Vac14_Fab1_bd	<199..256	CDD:289521	22/56 (39%)
		HEAT repeat	200..222	CDD:293787	7/21 (33%)
		HEAT repeat	234..273	CDD:293787	14/38 (37%)
		HEAT repeat	283..312	CDD:293787	14/28 (50%)
		HEAT repeat	321..348	CDD:293787	20/26 (77%)
		HEAT repeat	361..399	CDD:293787	21/37 (57%)
		HEAT repeat	412..442	CDD:293787	18/29 (62%)
		HEAT repeat	448..476	CDD:293787	14/27 (52%)
		HEAT repeat	487..513	CDD:293787	10/25 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336564
Domainoid	1	1.000	486	1.000	Domainoid score	I375
eggNOG	1	0.900	-	-		E1_KOG2259
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69427
Inparanoid	1	1.050	514	1.000	Inparanoid score	I1252
OMA	1	1.010	-	-		QHG49995
OrthoDB	1	1.010	-	-		D204348at33208
OrthoFinder	1	1.000	-	-		FOG0006609
OrthoInspector	1	1.000	-	-		oto97147
orthoMCL	1	0.900	-	-		OOG6_104599
Panther	1	1.100	-	-	LDO	PTHR20938
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4846
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770