DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IntS4 and ints-4

DIOPT Version :9

Sequence 1:	NP_572488.1	Gene:	IntS4 / 31793	FlyBaseID:	FBgn0026679	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	NP_493396.1	Gene:	ints-4 / 173238	WormBaseID:	WBGene00012234	Length:	1071	Species:	Caenorhabditis elegans

Alignment Length:	1026	Identity:	244/1026 - (23%)
Similarity:	407/1026 - (39%)	Gaps:	228/1026 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 ALVLPTGTPVASTGAPSTGVIGNPPAAATGAPPMTAANSRELLELLVKITDEISYEDVEMGELKE 130
            |.:||....:..|....:|...:..:.|:...|   |:.:..:|           :.:.|.|.::
Worm   140 AKILPDPRRIVETSNFDSGAESDTDSEASNKKP---ADFKPRIE-----------DILPMDEEED 190

  Fly   131 VASKIFQLYQLQERDSDTSIRVKLLELLSGLGCECATEQALTMIIDYFIFLLRKEVSQ------- 188
            ..|.|..||.....||.                          ::..:..:||:::.|
Worm   191 EISMIDALYLKPNLDSG--------------------------VLTIYTMVLREKIIQADEVPEK 229

  Fly   189 -KVLAQGMMCLFRIGERRKHMLPISYKTQVAHLAKEQLRSGSAHTQKNAMLVIGRFATKMEGERH 252
             |:.|:..:....|.........|.:...:|      :.|.|:.:::.:........|::.|:|
Worm   230 IKLCARRSLAYSSISSTANRTAAIDFHVALA------ISSSSSTSEEESAAQCESLLTRLAGDR- 287

  Fly   253 YVWKLAFYIDSQDSSVRAQALHALLTLGERGSQLPAVLYKRAVEAMKDDYECVRKEALQLVFMLG 317
                        |..||..|...||.| ....:|....|:.|...|.|....:|..|::|:....
Worm   288 ------------DFRVRKSAAEGLLAL-SNVFKLSKATYQLAKTHMADSDSDIRIAAIKLLIFYA 339

  Fly   318 NRHPDYILPSDRQQEEL-----RMIDAAFSKVCEALCDLSLQIRVLAAELLGGMTAVSREFLHQT 377
            ||         |.:||:     ::.|.|||.:|:|:.|:.:.:||.||:.||....||.|.::||
Worm   340 NR---------RGEEEIEGTNKKLYDDAFSSICDAINDIEIGVRVEAAKKLGDFEQVSEELIYQT 395

  Fly   378 LDKKLMSNL------------------------RRKRTAHERGARLVASGEWSSGKRWADDAPQE 418
            ||||:|.:.                        ||.:.|.:......:.|.||.||......|.|
Worm   396 LDKKMMRSTTNQQVVKVQQSLFALSKKASTNRDRRWKFAKKAPKMQESRGGWSRGKELNASVPSE 460

  Fly   419 HL-----------------DAQSISIIASGACGALIHGLEDEFLEVRTAAVASMCKLALSRPDFA 466
            ..                 :.:..|||..|||||.:..|||||::||.|||.|:.:||.:||.||
Worm   461 EEKKKNGVEGAEKNDDDDDNEEEESIIPHGACGAFVSALEDEFMDVRKAAVYSLGRLACTRPTFA 525

  Fly   467 VTSLDFLVDMFNDEIEDVRLKAIYSLTAIAKHIVLREDQLEIMLGSLEDYSVDVREGLHLMLGAC 531
            |::|::|.||||||:.||||.||.:||.:..|..:..:||.::...|:|...:.|:.:..:|...
Worm   526 VSALEYLADMFNDEMADVRLDAINALTPLIAHGQINSEQLNVISKCLDDAMPEARQAMRELLKRA 590

  Fly   532 RVSTQTCLLMVVQKLLDVLAKYPQDRNSTYACMRKIGQKHPHLVMAVAVHLLYVHPFFETPERDV 596
            :.....|:.|.|:.||..|.::|:|::..|.||..||:.|...|.::...||.:|..|.|.|..:
Worm   591 QFVDLNCIEMCVKALLSCLKRFPKDKDEIYGCMADIGKNHGVQVQSIMRSLLDIHLIFHTRESSI 655

  Fly   597 EDPAYLCVLILVFNAAEHLVPIISLLPTATHRHYAYLRDSMPNLVPQLPIEGASSASATHRIDSA 661
            ||..|:..||:|.|||.....::..:|...||||.:||::.||||  .||          |:...
Worm   656 EDQEYVGKLIMVLNAAAFQPSMVHFMPEFVHRHYRFLRNASPNLV--RPI----------RVLDE 708

  Fly   662 MHQAGSSAEYLQMILSHIEEIFTMTDERL-ELLQTAQ---SNLQR---------LGSIDAGMYGT 713
            ..|.|..::..:......||:...|..|| .:..|||   .|:||         :...::.:.|.
Worm   709 EKQIGRCSKSDEKTNEKAEEVVMNTYYRLCNVTATAQLVDRNIQRDEIFRDTSAISLYNSSVSGA 773

  Fly   714 SNFLETFLAAQIQIEQMQRCASTQRSRVPLKESLAALIRNCLKLQHTFSG--------------- 763
            :..:.........::.:............:|:.:...|.:...::|.|||
Worm   774 ARLIFCLGEVSSHVDSITNTVLRGGELTNVKQLIGQSIEDMQSIEHQFSGISMQIHSYLIYCRVY 838

  Fly   764 LNYGDIL----QVKQLRLRACALHLVLV--------------VRDRSQSALGPCQMLLQTAGDIS 810
            |::.|:|    ||...::..|....:::              :.|...:.|..|:.:. :.||
Worm   839 LSFLDMLIWMMQVMTSQIDVCNAGQLIIQDSKIIIEDGPFREISDELSTFLASCEQIF-SVGD-- 900

  Fly   811 EFIKANTKDEEEKPPVVETDMPMKESVSRDAQPDSFTRQLLIKLDGISDPKPGRVFREILPLVQQ 875
               :.|....|||..::                   |...|:.|...|.||
Worm   901 ---QRNPIGLEEKRKII-------------------TPTTLVNLLDKSIPK-------------- 929

  Fly   876 APPLALPPANDKIRRCVANILEPCPLQSQDNVIKVTAGLIAAVPFVAEIDNLLESQKADMRIKIK 940
             .||..|.|. .|....|.|..|....:.:||:|..|.|...:|...::.|:...:...:|||..
Worm   930 -LPLKFPSAG-SIHLKYARITNPNKDSAVENVLKFFAHLPHGIPLEFDLFNMKVDELDSVRIKTV 992

  Fly   941 YPDQHMHTVVPKQSDFKPIMTEQGEHKTNVRLRTTILLSHSVWTESSLVEI 991
            :||.....:.|:   .:.|..|........:::.|   ..|.|:|.:.:::
Worm   993 HPDGQFDVMRPR---IEEIRNENSHFSVTTQVKVT---CSSPWSEPAEIDV 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS4	NP_572488.1	HEAT repeat	290..326	CDD:293787	9/35 (26%)
		HEAT repeat	339..414	CDD:293787	30/98 (31%)
		HEAT repeat	432..459	CDD:293787	15/26 (58%)
		HEAT repeat	468..498	CDD:293787	16/29 (55%)
		HEAT repeat	504..528	CDD:293787	5/23 (22%)
ints-4	NP_493396.1	PRK13800	<277..552	CDD:237512	96/297 (32%)
		HEAT repeat	279..301	CDD:293787	8/34 (24%)
		HEAT repeat	312..340	CDD:293787	7/27 (26%)
		HEAT repeat	357..386	CDD:293787	12/28 (43%)
		HEAT repeat	491..518	CDD:293787	15/26 (58%)
		HEAT repeat	527..557	CDD:293787	16/29 (55%)
		HEAT repeat	565..591	CDD:293787	5/25 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157375
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2259
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	240	1.000	Inparanoid score	I2110
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204348at33208
OrthoFinder	1	1.000	-	-		FOG0006609
OrthoInspector	1	1.000	-	-		oto17875
orthoMCL	1	0.900	-	-		OOG6_104599
Panther	1	1.100	-	-	LDO	PTHR20938
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3511
SonicParanoid	1	1.000	-	-		X4846
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.790